9 results match your criteria: "The National Centre for Research and Care of Alzheimer's and Mental Diseases[Affiliation]"
The in vivo topography of cortical changes in healthy aging and prodromal Alzheimer's disease.
Suppl Clin Neurophysiol
October 2013
Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, The National Center for Research and Care of Alzheimer's and Mental Diseases, 25125 Brescia, Italy.
Background: Gray matter atrophy is regarded as a valid marker of neurodegeneration in Alzheimer's disease (AD), but few studies have investigated in detail the topographic changes associated with normal aging. In addition, few studies have compared the changes in the earliest clinical stage of AD (prodromal AD (pAD)) with those of healthy aging. Here we aimed to investigate the topographical distribution of age-related cortical atrophy and to compare it with that associated with prodromal and estabilished AD.
View Article and Find Full Text PDFMapping the structural brain changes in Alzheimer's disease: the independent contribution of two imaging modalities.
J Alzheimers Dis
February 2012
LENITEM - Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer's and Mental Diseases, Brescia, Italy.
The macrostructural atrophy of Alzheimer's disease (AD) has been fully described. Current literature reports that also microstructural alterations occur in AD since the early stages. However, whether the microstructural changes offer unique information independent from macrostructural atrophy is unclear.
View Article and Find Full Text PDFHippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.
Psychiatry Res
May 2011
LENITEM-Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer's and Mental Diseases, Brescia, Italy.
Patients with Alzheimer's disease (AD) and schizophrenia display cognitive, behavioural disturbances and morphological abnormalities. Although these latter reflect progressive neurodegeneration in AD, their significance in schizophrenia is still unclear. We explored the patterns of hippocampal and amygdalar atrophy in those patients and their associations with clinical parameters.
View Article and Find Full Text PDFCortical changes in incipient Alzheimer's disease.
J Alzheimers Dis
May 2011
Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer's and Mental Diseases, Brescia, Italy.
Mild cognitive impairment (MCI) is defined by memory impairment with no impact on daily activities. 10 to 15% of MCI convert to Alzheimer's disease (AD) per year. While structural changes in the cortex of AD patients have been extensively investigated, fewer studies analyzed changes in the years preceding conversion.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the distinct contributions of macrostructural and microstructural changes in the brains of Alzheimer's disease (AD) patients, emphasizing the relevance of both types of imaging for understanding disease pathology.
- Seventeen patients with moderate-severe AD and 13 healthy controls underwent MRI scans to analyze both macrostructural atrophy and microstructural damage.
- Results indicate that microstructural diffusion changes offer unique insights into the disease that volumetric measurements alone cannot provide, highlighting key brain regions affected in AD.
In vivo neuropathology of cortical changes in elderly persons with schizophrenia.
Biol Psychiatry
September 2009
LENITEM-Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, the National Centre for Research and Care of Alzheimer's and Mental Diseases, Brescia, Italy.
Background: Elderly schizophrenia patients frequently develop cognitive impairment of unclear etiology. Magnetic resonance imaging (MRI) studies revealed brain structural abnormalities, but the pattern of cortical gray matter (GM) volume and its relationship with cognitive and behavioral symptoms are unknown.
Methods: Magnetic resonance scans were taken from elderly schizophrenia patients (n = 20, age 67 +/- 6 SD, Mini-Mental State Examination [MMSE] 23 +/- 4), Alzheimer's disease (AD) patients (n = 20, age 73 +/- 9, MMSE 22 +/- 4), and healthy elders (n = 20, age 73 +/- 8, MMSE 29 +/- 1).
In vivo mapping of incremental cortical atrophy from incipient to overt Alzheimer's disease.
J Neurol
June 2009
Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer's and Mental Diseases, via Pilastroni 4, 25125, Brescia, Italy.
Article Synopsis
- Progressive brain atrophy is recognized as a key indicator of Alzheimer's disease (AD), and studying its patterns can help identify affected neural networks.
- A study involved 61 participants grouped by cognitive health and AD severity, using 3D MRI scans for detailed analysis of gray matter loss across different stages.
- Results showed significant cortical gray matter loss in distinct areas: incipient AD patients displayed changes in the hippocampal pathways, while those with mild and moderate AD had widespread losses affecting sensory and visual areas, indicating progression in brain atrophy linked to the disease stages.
Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla.
Brain
December 2008
Laboratory of Epidemiology Neuroimaging & Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer's and Mental Diseases, Brescia, Italy.
Article Synopsis
- Histological studies indicate different roles of hippocampal subfields in ageing and Alzheimer's disease.
- The study involved analyzing high-resolution MRI images of 19 Alzheimer's patients and 19 healthy controls to measure in vivo hippocampal changes.
- Findings revealed that while ageing leads to reduced hippocampal volume significantly correlating with age, Alzheimer's disease causes even greater atrophy in specific areas, particularly the CA1 subfield, showing overlapping but distinct patterns from normal ageing.
The topography of grey matter involvement in early and late onset Alzheimer's disease.
Brain
March 2007
Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer's and Mental Diseases, Brescia, Italy.
Clinical observations have suggested that the neuropsychological profile of early and late onset forms of Alzheimer's disease (EOAD and LOAD) differ in that neocortical functions are more affected in the former and learning in the latter, suggesting that they might be different diseases. The aim of this study is to assess the brain structural basis of these observations, and test whether neocortical areas are more heavily affected in EOAD and medial temporal areas in LOAD. Fifteen patients with EOAD and 15 with LOAD (onset before and after age 65; Mini Mental State Examination 19.
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