332 results match your criteria: "The National Center for Global Health and Medicine[Affiliation]"

A scoping review and thematic analysis of the effects of tropical cyclones on diarrheal diseases.

Environ Epidemiol

February 2025

Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Tropical cyclones pose significant health risks and can trigger outbreaks of diarrheal diseases in affected populations. Although the effects of individual hazards, such as rainfall and flooding, on diarrheal diseases are well-documented, the complex multihazard nature of tropical cyclones is less thoroughly explored. To date, no dedicated review comprehensively examines the current evidence and research on the association between tropical cyclones and diarrheal diseases.

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Coagulase-negative (CoNS) is a rare cause of UTIs in children and is often regarded as a contaminant in urine samples. We report a case of acute focal bacterial nephritis (AFBN) and bacteremia caused by following an upper respiratory infection in a pediatric patient. The patient, a four-year-old girl, presented with fever, cough, and a runny nose two days before being referred to our hospital due to persistent fever and poor oral intake.

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Objective: It remains unclear whether general hospitals without psychiatric wards can provide sufficient services for both physical and mental health needs, as they often lack adequate psychiatrists, primarily due to cost constraints. This article explores the relationship between the number of full-time psychiatrists and functionality for integrating physical and mental health services in these settings.

Methods: The Medical Policy Committee of the Japanese Society of General Hospital Psychiatry conducted a nationwide survey in 2022 to evaluate the detailed scope and volume of service of psychiatric departments in general hospitals without a psychiatric ward.

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Purpose: Little is known about the effects of ambient atmospheric pressure (AP) on intraocular pressure (IOP) under ordinary conditions. This study aimed to investigate the effects of AP on Goldmann applanation tonometer-measured IOP (GAT-IOP) in normal eyes under everyday atmospheric conditions adjusting for effects of possible confounding factors including other climatic factors.

Methods: Data obtained from 2,431 normal healthy eyes of 2,431 subjects (mean age: 56.

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Article Synopsis
  • * A systematic review of 335 cases revealed that Mycobacterium abscessus was the most frequently identified pathogen, with many patients receiving treatment using multiple antibiotics.
  • * Early diagnosis using acid-fast bacilli staining and culture is crucial, and catheter removal may be necessary for effective management of these NTM infections.
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  • A study reviewed 106 patients with advanced urothelial carcinoma treated with the antibody-drug conjugate enfortumab vedotin (EV) between 2021 and 2023 to evaluate the impact of treatment-related adverse events (trAEs) on survival outcomes.* -
  • The results indicated that 88.7% of patients experienced some form of trAEs, with skin and gastrointestinal issues being the most common, and a landmark analysis suggested that trAEs were linked to longer overall survival, particularly physical trAEs.* -
  • The study concluded that managing trAEs and understanding their prognostic value is important for improving the outcomes of EV therapy in these patients, highlighting that physical trAEs were
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Background: We aimed to examine the effectiveness of a nurse-led, screening-triggered early specialized palliative care intervention program for patients with advanced lung cancer.

Methods: Patients with advanced lung cancer who underwent initial chemotherapy were randomized to intervention and usual care groups between January 2017 and September 2019. The intervention comprised comprehensive needs assessments, counseling, and service coordination by advanced-level nurses.

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In prospective Japanese studies of pediatric renal tumors, 5-year event-free survival and overall survival (OS) for patients with nephroblastoma ranges from 75-90% and 89-97%, respectively. However, treatments strategies for recurrent nephroblastoma in Japanese patients remain unclear. This retrospective study aimed to inform the development of treatment strategies by analyzing the long-term results and side effects of salvage therapies for recurrent nephroblastoma in Japan.

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Correlation between severity of preoperative low back pain and postoperative outcomes in lumbar disc herniation surgery: a retrospective cohort study.

Spine J

November 2024

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan; University of Tokyo Spine Group (UTSG), 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. Electronic address:

Background Context: Low back pain (LBP) frequently occurs in patients with lumbar disc herniation (LDH), however the extent to which discectomy ameliorates it and how preoperative LBP influences postoperative outcomes remains unclear.

Purpose: To evaluate the improvement in LBP and its impact on postoperative patient-reported outcome measures (PROMs).

Study Design/setting: Multicenter retrospective observational study.

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Article Synopsis
  • The study analyzed data from 93 participants with type 1 diabetes to explore how the frequency of scanning with intermittent-scanning continuous glucose monitoring (isCGM) affects time in range (TIR), time above range (TAR), and time below range (TBR) throughout the day.
  • Increased scanning frequency was linked to higher TIR, particularly in the afternoon, evening, and night, and was associated with lower TAR and TBR during these times.
  • Psychological factors, such as concerns about blood glucose levels affecting social interactions and feelings of loneliness, were found to influence how often participants scanned their glucose levels.
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  • Remote organ dysfunction is common after lung transplantation and may negatively impact the patient’s outcome, prompting an investigation into protective measures.
  • A study on mice showed that lung transplantation increased specific molecular markers of injury in the kidneys and liver, indicating a response to the transplant.
  • Ropivacaine, while previously shown to reduce acute rejection in lung transplants, did not significantly affect inflammation markers in the remote organs during this study.
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  • The study investigates the effectiveness of the fludarabine/intravenous busulfan (FB4) regimen in patients with myelodysplastic syndrome (MDS) undergoing stem cell transplantation from unrelated donors, comparing FB4 alone, FB4 with anti-thymoglobulin (ATG), and FB4 with low-dose total body irradiation (TBI).
  • Results show that the combination of FB4 with low-dose ATG significantly improved overall survival (OS) and reduced nonrelapse mortality (NRM) compared to FB4 alone, whereas the FB4 with TBI did not demonstrate notable advantages over the FB4 regimen.
  • The study highlights that using FB4 plus low-dose ATG is associated with better outcomes
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  • Thromboembolism is a critical concern in patients undergoing endovascular treatment for ruptured cerebral aneurysms, and administering antiplatelet agents like aspirin before the procedure may lower this risk.
  • The study, called ASTOP, is a multicenter, randomized, double-blind trial involving 484 patients, comparing the effects of 200 mg of aspirin versus a placebo prior to treatment.
  • Primary outcomes will focus on measuring thromboembolic complications and ischemic lesions during the procedure, while secondary outcomes will assess cerebral ischemic events, bleeding incidents, and patient functional status after 90 days.
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  • The ALL-R08 study in Japan focuses on children with first-relapsed acute lymphoblastic leukemia (ALL) to evaluate the effectiveness of the BFM-S classification and measurable residual disease (MRD) as prognostic tools for patient survival.
  • The study consists of two parts: an observational study (ALL-R08-I) and a clinical trial (ALL-R08-II) that differentiates treatment based on MRD levels after induction therapy.
  • Results showed varying 3-year event-free survival rates across different BFM-S groups, indicating that children treated with either Japanese or BFM-type protocols have similar outcomes for managing first-relapsed ALL.
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Histoplasmosis is caused by Histoplasma capsulatum and is prevalent in areas of the world where H. capsulatum is endemic. We herein report a patient diagnosed with HIV-1 who developed histoplasmosis from a non-H.

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Complete medical examinations are a system of preventive medicine unique to Japan. In recent years, Japanese and foreigners have been aware of complete medical examinations. However, the extent to which this concept of comprehensive medical checkup is recognized in different counties is unknown.

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Intermediate cystinosis: a case report of 10-year treatment with cysteamine.

BMC Nephrol

August 2024

Department of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine (NCGM), 1-21-1 Toyama Shinjuku-Ku, Tokyo, 162-8655, Japan.

Background: Cystinosis is a lysosomal storage disorder characterized by an autosomal recessive phenotype. Intermediate cystinosis, which progresses slowly and causes renal failure, accounts for approximately 5% of all cystinosis cases. Patients with intermediate cystinosis may not exhibit the typical symptoms of cystinosis, such as Fanconi syndrome and ocular symptoms.

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Strengthening International Collaboration for Global Health Security: The Role of the Infectious Disease Emergency Specialist Training Program and NETEC Partnership.

Health Secur

September 2024

Hiromi Hibino, MD, MSc, is Liaison, National Emerging Special Pathogens Training and Education Center (NETEC), and Senior Scientist, Bureau of Strategic Planning; Yukimasa Matsuzawa, MD, PhD, is Deputy Director of Global Outbreak Intelligence, Capacity Building and Deployment Coordination Center, Disease Control and Prevention Center (DCC); Shinichiro Morioka, MD, is Deputy Chief Medical Director, DCC; Teiji Takei, MD, MBA, is Director-General, Bureau of Strategic Planning; and Norio Omagari, MD, MSc, PhD, is Director, DCC; all at the National Center for Global Health and Medicine, Tokyo, Japan. Jocelyn J. Herstein, PhD, MPH, is an Assistant Professor, Department of Environmental, Agricultural and Occupational Health, College of Public Health, and Director, NETEC International Partnerships and Programs; Katie L. Stern, MPH, is a Program Evaluation Specialist, Global Center for Health Security; and John J. Lowe, PhD, is Director, Global Center for Health Security, Professor and Interim Chair, Department of Environmental, Agricultural and Occupational Health, College of Public Health, and Assistant Vice Chancellor for Health Security Training and Education, Office of the Vice Chancellor for Academic Affairs; all at the University of Nebraska Medical Center, Omaha, NE. Jun Sugihara, MD, PhD, is Principal Deputy Director, Division of Infectious Disease Prevention and Control, Department of Infectious Disease Prevention and Control, and Public Health Bureau, Ministry of Health, Labour and Welfare, Tokyo, Japan. Adam Tewell, MA, MPA, is a Senior Emergency Management Specialist, International Operations; and Richard C. Hunt, MD, FACEP, is a Senior Medical Advisor, Office of Health Care Readiness; both at the Administration for Strategic Preparedness and Response, Washington, DC. Vikramjit Mukherjee, MD, FRCP, is Director, Critical Care, and Director, Special Pathogens Program, NYC Health + Hospitals/Bellevue, and Associate Professor, NYU School of Medicine, New York, NY.

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Herein, we present two cases of isolated suprasellar dissemination of glioblastoma in patients with well-controlled primary lesions. A 22-year-old woman and a 56-year-old woman developed rapid growth of suprasellar glioblastoma dissemination 26 and 17 months after initial surgery, respectively. Both patients presented with acute visual impairment (decreased acuity and visual field disturbances) but lacked severe pituitary dysfunction.

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Introduction: It is challenging for pregnant women with type 1 diabetes to maintain optimum glucose level to attain good neonatal outcomes. This study evaluated the efficacy of sensor-augmented insulin pump (SAP) with a predictive low-glucose suspend (PLGS) system in pregnant Japanese women with type 1 diabetes.

Materials And Methods: SAP with PLGS was used in 11 of the 22 women with type 1 diabetes who delivered between 2011 and 2021 at the two medical institutions in Japan.

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Transformation of mutated lung adenocarcinoma to small-cell carcinoma long after the cessation of tyrosine kinase inhibitor treatment: A case series and literature review.

Respir Med Case Rep

June 2024

Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, Japan.

Article Synopsis
  • - Histological transformation from lung adenocarcinoma to small-cell lung cancer (SCLC) can occur as a resistance mechanism to EGFR-TKIs, typically seen during treatment, but can also happen long after stopping the drugs.
  • - The study reports three cases where patients experienced this transformation with rapid tumor progression and increased levels of SCLC markers.
  • - Emphasizing continuous monitoring of tumor behavior and SCLC markers is crucial to prevent delays in diagnosis and ensure timely treatment adjustments.
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