2 results match your criteria: "The NanoBiotechnology Center at Roswell Park Cancer Institute-NBC at RPCI[Affiliation]"
In vivo toxicity evaluation of gold-dendrimer composite nanodevices with different surface charges.
Nanotoxicology
June 2013
Department of Radiation Medicine, and joint appointment in the Department of Cell Stress Biology, The NanoBiotechnology Center at Roswell Park Cancer Institute-NBC at RPCI, Buffalo, NY, USA.
Composite nanodevices (CNDs) are multifunctional nanomaterials with potential uses in cancer imaging and therapy. Poly(amidoamine) dendrimer-based composite nanodevices are important members of this group and consist of an organic dendrimer component and an incorporated inorganic component, in this case, gold. This study addresses the short- (14 days) and long-term (78 days) in vivo toxicity of generation-5 (G5; 5 nm) PAMAM dendrimer-based gold-CNDs (Au-CNDs) with varying surface charges (positive, negative and neutral) in C57BL/6J male mice.
View Article and Find Full Text PDFSignificant effect of size on the in vivo biodistribution of gold composite nanodevices in mouse tumor models.
Nanomedicine
December 2007
The NanoBiotechnology Center at Roswell Park Cancer Institute (NBC at RPCI), Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Article Synopsis
- There is increasing interest in multifunctional drug delivery systems, particularly composite nanodevices (CNDs), which can be used for diagnosing and treating diseases like cancer.
- The study investigates how the size and surface charge of gold-dendrimer CNDs influence their behavior in mouse tumor models, specifically focusing on biodistribution and excretion patterns.
- Findings reveal that both size and surface charge significantly impact where these CNDs accumulate in the body, suggesting potential for tailored nanodevice design for targeted medical applications.