21 results match your criteria: "The Mount Vernon Hospital[Affiliation]"

Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and activities of transcriptional factors involved in both cancer initiation and progression through alteration of either DNA or the structural components of chromatin. Recently, the role of gene repression through modulation such as acetylation in cancer patients has been clinically validated with several inhibitors of HDACs. One of the HDAC inhibitors, vorinostat, has been approved by FDA for treating cutaneous T-cell lymphoma (CTCL) for patients with progressive, persistent, or recurrent disease on or following two systemic therapies.

View Article and Find Full Text PDF

Noninvasive assessment of visco-elasticity in the presence of accumulated soft tissue fluid.

J Surg Res

August 2007

Life Support Technologies, Inc.-NEWT Technologies, Inc., The Mount Vernon Hospital, Sound Shore Health System, Mount Vernon, New York, USA.

Background: The diagnosis of compartment syndrome is made by clinical examination, but direct compartmental measurements are important and serve an adjunctive role in establishing the diagnosis. This study examines a noninvasive screening method for differentiating compartmental syndrome from edema without elevated internal pressure.

Materials And Methods: The study groups consisted of 16 normals, 22 subjects with edema, and 2 subjects with compartmental syndrome.

View Article and Find Full Text PDF

Hyperbaric oxygen and lymphoid system function: a review supporting possible intervention in tissue transplantation.

Technol Health Care

October 2007

Life Support Technology Group and NEW Technology, Inc, The Mount Vernon Hospital, Sound Shore Health System, Mount Vernon, NY 10550, USA.

This review addresses the many ways that hyperbaric oxygen (HBO2) has been found to mitigate immune reactions, many of which are involved in rejection of allograft transplants, and thus offers a rationale for its possible use as an adjunct to help preserve and protect transplanted tissues. Rejection may involve both immunological reactions of the lymphoid system, or lymphoid-independent damage from trauma or other factors, including reperfusion injury. Lymphoid-induced damage involves cellular elements such as CD4 and macrophage cell types, as well as both proinflammatory and inhibitory cytokines.

View Article and Find Full Text PDF

A combination of radiotherapy, nitric oxide and a hyperoxygenation sensitizing protocol for brain malignant tumor treatment.

Med Hypotheses

April 2007

Life Support Technologies Group, NEWT Technologies, Inc., The Mount Vernon Hospital, Sound Shore Health System, New York, USA.

Brain malignant tumor such as glioblastoma is a challenging medical and surgical problem. In spite of surgery, radiotherapy and chemotherapy, the prognosis is still very poor. The limitations of currently available treatment modalities to cure or significantly prolong and improve the quality of life should stimulate rigorous research and studies to combat brain malignant tumors.

View Article and Find Full Text PDF

Influences of hyperbaric oxygen on blood pressure, heart rate and blood glucose levels in patients with diabetes mellitus and hypertension.

Arch Med Res

November 2006

Life Support Technologies, Inc., NEWT Technologies, Inc., Chronic Wound Treatment and Hyperbaric Medicine Center, The Mount Vernon Hospital, New York Medical College, New York, NY 10550, USA.

Background: We investigated the influences of hyperbaric oxygen (HBO(2)) on systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and blood glucose level (BGL).

Methods: Forty one patients with hypertension (HTN), diabetes mellitus (DM), HTN and DM and/or no HTN or DM underwent HBO(2) sessions (15-40 sessions for each patient). SBP, DBP, HR and BGL (for diabetics) were recorded before and after each session.

View Article and Find Full Text PDF

Phototherapy and malignancy: possible enhancement by iron administration and hyperbaric oxygen.

Med Hypotheses

May 2009

Life Support Technologies, Inc. - NEWTechnologies, Inc., The Chronic Wound Management and Hyperbaric Medicine Center, The Mount Vernon Hospital, Sound Shore Health System, Mount Vernon, 7th Avenue, North 12, New York 10550, USA.

Photodynamic therapy (PDT) is a new therapeutic approach for the treatment of malignant tumors. Hyperbaric oxygen (HBO(2)) shows beneficial effects in various modalities of cancer interventions. Tumor cells tend to accumulate large amount of iron.

View Article and Find Full Text PDF

Postsurgical psychosis: case report and review of literature.

Adv Ther

July 2006

Methodist Medical Center, The Mount Vernon Hospital, Life Support Technology Groups, Mount Vernon, New York 10550, USA.

A wide range of behavioral symptoms may occur following surgery, including depression, hallucinations, true psychosis, mania, and impulsivity. Psychoses, including those that occur postoperatively, are among the most frequent indications for hospitalization in the United States and are associated with a substantially increased rate of morbidity. The exact cause of postoperative psychosis has not been identified.

View Article and Find Full Text PDF

Heroin abuse causes various medical and surgical complications. We report a case of heroin-induced severe bilateral compartment syndrome complicated by rhabdomyolysis, acute renal failure and extremely elevated creatinine kinase. A 30-year-old male heroin addict presented to the emergency department of Mount Vernon Hospital, Mount Vernon, New York complaining of severe pain and burning sensation in both legs and feet 1 day after abusing intravenous heroin.

View Article and Find Full Text PDF

Effects of hyperbaric oxygen on inflammatory response to wound and trauma: possible mechanism of action.

ScientificWorldJournal

April 2006

Life Support Technologies, Inc., Chronic Wound Treatment and Hyperbaric Medicine Center, The Mount Vernon Hospital, Mount Vernon, NY 10550, USA.

There is growing interest in expanding the clinical applications for HBO2 (hyperbaric oxygen therapy) into new medical and surgical fields. The pathophysiology of response towards wounds, infection, trauma, or surgery involves various chemical mediators that include cytokines, prostaglandins (PGs), and nitric oxide (NO). The beneficial role played by HBO2 in wound healing, carbon monoxide poisoning, decompression sickness, and other indications is well documented.

View Article and Find Full Text PDF

Hyperbaric oxygen in the treatment of patients with cerebral stroke, brain trauma, and neurologic disease.

Adv Ther

April 2006

Life Support Technologies, Inc., and NewTechnologies, Inc., The Mount Vernon Hospital, Westchester Medical Center, New York Medical College, New York, USA.

Hyperbaric oxygen (HBO) therapy has been used to treat patients with numerous disorders, including stroke. This treatment has been shown to decrease cerebral edema, normalize water content in the brain, decrease the severity of brain infarction, and maintain blood-brain barrier integrity. In addition, HBO therapy attenuates motor deficits, decreases the risks of sequelae, and prevents recurrent cerebral circulatory disorders, thereby leading to improved outcomes and survival.

View Article and Find Full Text PDF

Effects of honey on the urinary total nitrite and prostaglandins concentration.

Int Urol Nephrol

September 2006

Dubai Specialized Center, Dubai and Life Support Technologies, Inc. and NewTechnologies, Inc., The Mount Vernon Hospital, 7th Avenue 12 North, Mount Vernon, NY 10550, USA.

Objectives: To evaluate effects of natural and artificial honey solutions on urinary nitrite content, prostaglandin excretion and urinary variables in healthy individuals.

Methods: The study comprised 12 individuals, nine males and three females; age range 25-45 years. Urinary total nitrite, prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha) and thromboxane B2 (TXB2) were assessed in spot morning sample and 1, 2, and 3 hours after ingestion of 80 g of natural honey dissolved in 250 ml water.

View Article and Find Full Text PDF

Over the past 40 years, hyperbaric oxygen (HBO2) therapy has been recommended and used in a wide variety of medical conditions. In the 1950s, HBO2 was first used as a treatment, in addition to radiation, for head and neck cancers and cervical cancer. Many studies have been conducted to investigate possible therapeutic effects HBO2 as part of cancer management.

View Article and Find Full Text PDF