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13 results match your criteria: "The Methodist Research Institute[Affiliation]"
Int J Mol Sci
November 2018
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Nuevo León 64849, Mexico.
Heart failure (HF) is a cardiovascular syndrome characterized by maladaptive changes with an underlying inflammatory mediated pathogenesis. Nevertheless, current therapy is aimed at the heart workload and neurohormonal axis; thus, prognosis remains poor. To continue improving treatment, we rely on murine models for a better understanding of HF pathophysiology.
View Article and Find Full Text PDFOphthalmology
February 2019
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Purpose: To characterize the ocular phenotype of DICER1 syndrome.
Design: Prospective, single-center, case-control study.
Participants: One hundred three patients with an identified germline pathogenic DICER1 variant (DICER1 carriers) and 69 family control participants underwent clinical and ophthalmic examination at the National Institutes of Health between 2011 and 2016.
Int J Nanomedicine
December 2014
Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy ; Interregional Research Center for Food Safety and Health, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
The aim of this study was the evaluation of the effects of two emulsifiers on the physicochemical and technological properties of low molecular weight chitosan/poly (D,L-lactide-co-glycolide) (PLGA) nanoplexes and their transfection efficiency. Nanospheres were prepared using the nanoprecipitation method of the preformed polymer. The mean diameter and surface charge of the nanospheres were investigated by photocorrelation spectroscopy.
View Article and Find Full Text PDFBiomed Microdevices
February 2012
Department of NanoMedicine, The Methodist Research Institute, 6670 Bertner Avenue, 77030, Houston, TX, USA.
Two vesicular colloidal carriers, ethosomes® and transfersomes® were proposed for the topical delivery of linoleic acid, an active compound used in the therapeutic treatment of hyperpigmentation disorders, i.e. melasma, which is characterized by an increase of the melanin production in the epidermis.
View Article and Find Full Text PDFGlia
January 2010
Department of Neurology, Methodist Neurological Institute, The Methodist Research Institute, The Methodist Hospital, Houston, Texas, USA.
Through undefined mechanisms, dominant mutations in (Cu/Zn) superoxide dismutase-1 (mSOD1) cause the non-cell-autonomous death of motoneurons in inherited amyotrophic lateral sclerosis (ALS). Microgliosis at sites of motoneuron injury is a neuropathological hallmark of ALS. Extracellular mutant SOD1 (mSOD1) causes motoneuron injury and triggers microgliosis in spinal cord cultures, but it is unclear whether the injury results from extracellular mSOD1 directly interacting with motoneurons or is mediated through mSOD1-activated microglia.
View Article and Find Full Text PDFMinerva Chir
February 2009
Department of Surgery Weill, Cornell Medical College, the Methodist Research Institute, Houston, TX, USA.
Islet cell transplantation holds great promise for treating patients with type 1 diabetes mellitus (T1DM), and for preventing unstable metabolic state commonly refereed to as brittle diabetes in patients that undergo pancreatic resection given that it is a relatively noninvasive procedure and an attractive alternative to pancreas transplantation for restoring endogenous insulin secretion. The success of recent clinical trials for allogeneic islet transplantation as well as the increasing centers that perform auto-transplantation is showing that the beta cell replacement therapy for the treatment of patients with diabetes or total pancreatectomy has been firmly established. It needs only to be improved and made more widely available to the millions of desperate patients who search for alternatives to a life of insulin injections, hypoglycemia and the risks of end-organ damage.
View Article and Find Full Text PDFIEEE Trans Image Process
June 2008
Center for Biotechnology and Informatics, Department of Radiology, The Methodist Research Institute, Houston, TX 77030-2707, USA.
Context-based modeling is an important step in high-performance lossless data compression. To effectively define and utilize contexts for natural images is, however, a difficult problem. This is primarily due to the huge number of contexts available in natural images, which typically results in higher modeling costs, leading to reduced compression efficiency.
View Article and Find Full Text PDFArterioscler Thromb Vasc Biol
November 2005
The Methodist Research Institute, Houston, Texas, USA.
Objective: Mitomycin C (MMc) is an antibiotic that exerts a potent antiproliferative effect in tumor cells. Because the proliferation of vascular smooth muscle cells (VSMCs) plays a prominent role in the development of restenosis after percutaneous coronary interventions, the present study examined the effect of MMc on VSMC proliferation and on neointima formation after arterial balloon injury.
Methods And Results: Treatment of cultured rat aortic VSMCs with MMc (1 nmol to 30 micromol/L) inhibited VSMC proliferation in a concentration-dependent manner.
Platelets
May 2001
The Methodist Research Institute, Clarian Health Partners, Inc., Indianapolis 46202, IN, USA.
This study was undertaken to isolate phospholipids released from activated platelets and to investigate their biological activities. Freshly washed platelets were activated with freezing/thawing, thrombin, ionophore 23187, and arachidonic acid. Thrombin was incubated with platelet-rich plasma to promote synthesis and release of phospholipids from platelets.
View Article and Find Full Text PDFJ Hematother Stem Cell Res
December 1999
Experimental Cell Research Program, The Methodist Research Institute, Clarian Health Partners, Inc., Indianapolis, IN 46202, USA.
Angiogenesis, the formation of new blood vessels, is an important component of restoration of hematopoiesis after BMT, but the mediators involved in hematopoietic angiogenesis have not been identified. We examined the influence of the lipid growth factors, phosphatidic acid (PA), lysophosphatidic acid (LPA), and sphingosine 1-phosphate (S1P), on several angiogenic properties of endothelial cells, including migration and stabilization of vascular barrier integrity. In a previous study, PA was found to disrupt the permeability of established endothelial monolayers, an early event in the angiogenic response that liberates cells for subsequent mobilization.
View Article and Find Full Text PDFBiochim Biophys Acta
January 2000
Experimental Cell Research Program, The Methodist Research Institute, MPC 1417, 1701 N. Senate Ave., Indianapolis, IN 46202, USA.
Phosphatidylinositol 3'-kinase (PI 3'-kinase) plays an important role in the migration of hepatocytes, endothelial cells and neoplastic cells to agonists which activate cellular tyrosine kinases. We examined the PI 3'-kinase-dependent chemotactic responses of neutrophilic leukocytes induced by phosphatidic acid (PA) in order to clarify mechanisms by which the enzyme potentially influences cellular migration. Western analysis of immunoprecipitates indicated that PA induced the tyrosine phosphorylation of three distinct proteins involved in functional activation which co-immunoprecipitated in PA-stimulated cells.
View Article and Find Full Text PDFJ Cell Biochem
October 1999
Experimental Cell Research Laboratory, The Methodist Research Institute, Indianapolis, Indiana 46202,
Released into the vasculature from disrupted cells or transported to the surface of adjacent effectors, phosphatidate and related lipids may potentiate endothelial cell activation. However, the effect of these lipids on endothelial monolayer barrier integrity has not been reported. The present study documents the induction of endothelial monolayer permeability by phosphatidate.
View Article and Find Full Text PDFJ Appl Physiol (1985)
May 1998
Departments of Medicine, Physiology, and Biophysics, Indiana University School of Medicine, Richard Roudebush Veterans Affairs Center, and the Methodist Research Institute, Indianapolis, Indiana 46202, USA.
Increased vascular endothelial cell (EC) permeability and neutrophilic leukocyte (PMN) diapedesis through paracellular gaps are cardinal features of acute inflammation. Activation of the EC contractile apparatus is necessary and sufficient to increase vascular permeability in specific models of EC barrier dysfunction. However, it is unknown whether EC contraction with subsequent paracellular gap formation is required for PMN transendothelial migration in response to chemotactic factors.
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