4 results match your criteria: "The Metabolic Disease Hospital of Tianjin Medical University[Affiliation]"
Long noncoding RNA GAS5 impairs the proliferation and invasion of endometrial carcinoma induced by high glucose via targeting miR-222-3p/p27.
Am J Transl Res
April 2019
Department of Diabetic Nephropathy Hemodialysis, The Metabolic Disease Hospital of Tianjin Medical University, Key Laboratory of Hormone and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Disease Tianjin 300070, China.
Long noncoding RNAs (lncRNAs) have been identified to be critical functional regulator in the human tumors, while the deepgoing mechanism by which lncRNAs modulates the endometrial carcinoma is still elusive. In this work, we found that lncRNA GAS5 was under-expressed in the endometrial carcinoma tissue specimens, especially these samples with type 2 diabetes mellitus. Besides, the aberrant under-expression of GAS5 was correlated with the advanced tumor stage as well as poor prognosis outcome.
View Article and Find Full Text PDFmiR-194 suppresses high glucose-induced non-small cell lung cancer cell progression by targeting NFAT5.
Thorac Cancer
May 2019
Department of Diabetic Nephropathy Hemodialysis, Key Laboratory of Hormone and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Disease, The Metabolic Disease Hospital of Tianjin Medical University, Tianjin, China.
Background: Diabetes mellitus (DM) is linked to an increased risk of lung cancer; however, the exact molecular basis is unclear.
Methods: We used a microarray method and found a group of microRNAs differently expressed in lung cancer cells at high or low glucose treatment.
Results: Among these, miR-194 changed significantly, which indicated further analysis.
LncRNA LINC00968 accelerates the proliferation and fibrosis of diabetic nephropathy by epigenetically repressing p21 via recruiting EZH2.
Biochem Biophys Res Commun
October 2018
Department of Diabetic Nephropathy Hemodialysis, The Metabolic Disease Hospital of Tianjin Medical University, Tianjin, 300070, China. Electronic address:
Emerging evidence have indicated the vital roles of long noncoding RNAs (lncRNAs) in the pathophysiological process of diabetic nephropathy. However, the deepgoing mechanism that lncRNAs regulate the diabetic nephropathy pathogenesis is still ambiguous. In present study, we found that lncRNA LINC00968 expression was high-expressed in the diabetic db/db mouse tissue and high-glucose induced mesangial cells.
View Article and Find Full Text PDF[Correlation study between obesity and dawn phenomenon in patients with type 2 diabetes].
Zhonghua Nei Ke Za Zhi
January 2016
Department of Diabetic Nephrology, the Metabolic Disease Hospital of Tianjin Medical University, Key Laboratory of the Ministry of Health of Hormones and Development, Tianjin 300070, China.
Objective: To investigate the correlation between the frequency of dawn phenomenon and obesity in patients with type 2 diabetes.
Methods: This study was conducted in 98 patients with type 2 diabetes admitted to the Metabolic Disease Hospital of Tianjin Medical University from 2011 to 2014. The subjects were divided into 3 groups according to BMI: the normal weight (BMI 18.