2 results match your criteria: "The Medical Colleges of St. Bartholomew's and the Royal London Hospitals[Affiliation]"
The effect of naloxone on adrenocorticotropin and cortisol release: evidence for a reduced response in depression.
J Affect Disord
June 1999
Department of Psychological Medicine, The Medical Colleges of St. Bartholomew's and the Royal London Hospitals, West Smithfield, UK.
Article Synopsis
- The study explores the relationship between endogenous opioid peptides and the HPA axis in individuals with major depression, suggesting that reduced opioid tone may contribute to increased HPA axis activity.
- Results showed that depressed participants had a significantly lower cortisol response and a non-significantly lower ACTH response to naloxone compared to healthy controls, indicating a potential impairment in opioid regulation.
- The findings suggest a link between reduced opioid tone and self-medication behaviors in depression, highlighting the importance of opioid pathways in developing new antidepressant treatments, though the small sample size limits the strength of the conclusions.
Domestic violence: a hidden problem for general practice.
Br J Gen Pract
April 1996
Department of General Practice, Medical Colleges of St Bartholomew's and the Royal London Hospitals.
Domestic violence is a common problem that may affect more than a quarter of women. It is a complex area in which to undertake research. Studies often focus on selected populations and exhibit a diversity of design, making comparison difficult.
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