Association of inorganic arsenic exposure with liver cancer mortality: A meta-analysis.

Background: The association of long-term inorganic arsenic (iAs) exposure through drinking water with risk of liver cancer mortality remains controversial. Therefore, we reviewed and quantitatively summarized the evidence from observational studies with a meta-analysis.

Methods: Pertinent studies were identified by searching PubMed and China National Knowledge Infrastructure through May 2014 and by reviewing the reference lists of retrieved articles.

Association of vitamin A and β-carotene with risk for age-related cataract: a meta-analysis.

Objective: Whether vitamin A and β-carotene as nutrients are protective factors against cataracts remains unclear. Thus, the aim of this study was to summarize the evidence from epidemiologic studies of vitamin A and β-carotene with the risk for cataract.

Methods: Pertinent studies were identified by a search of PubMed, Web of Science, Google Scholar, and Wan Fang Med Online.

A hypothesis: hydrogen sulfide might be neuroprotective against subarachnoid hemorrhage induced brain injury.

Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. The gas H2S is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow, and leukocyte adhesion.

Elevation of serum CXCL16 level correlates well with atherosclerotic ischemic stroke.

Introduction: Currently there are no reliable biological markers for ischemic stroke. The novel chemokine CXCL16 is known to be involved in the development of atherosclerosis. Nevertheless, the real role of CXCL16 in atherosclerotic disorders remains uncertain.

Dose-response relationship of serum uric acid levels with risk of stroke mortality.

Introduction: Results from the recent meta-analysis suggested that higher serum uric acid (SUA) levels are positively associated with risk of stroke. However, the relationship of SUA levels with risk of stroke is still unclear.

Materials And Methods: Data from prospective cohort studies on SUA levels and risk of stroke mortality was used.

Dairy foods and risk of stroke: a meta-analysis of prospective cohort studies.

Background And Aims: Epidemiological studies evaluating the association of dairy foods with risk of stroke have produced inconsistent results. We conducted a meta-analysis to summarize the evidence from prospective cohort studies regarding the association between dairy foods and risk of stroke.

Methods And Results: Pertinent studies were identified by searching Embase (1950-November, 2013), Web of Knowledge (1950-November, 2013) and Pubmed (1945-November, 2013).

Relation between the expression of mitotic centromere-associated kinesin and the progression of squamous cell carcinoma of the tongue.

Objective: Mitotic centromere-associated kinesin (MCAK) is a microtubule depolymerase indispensable for microtubule binding during spindle formation. The purpose of this study was to investigate the association of MCAK expression with squamous cell carcinoma of the oral tongue (SCCOT).

Study Design: Immunohistochemistry was used in 47 cases of SCCOT.

SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population.

Sirtuin 2 (SIRT2) is a strong protein deacetylase, which is highly expressed in central nervous system. Recently, an association between SIRT2 rs10410544 polymorphism and late-onset Alzheimer's disease (LOAD) was found in the APOEε4-negative Caucasian population. To investigate the potential association between the rs10410544 C/T polymorphism of SIRT2 and the risk of LOAD, we conducted an independent replication case-control study in a Northern Han Chinese population comprising 1133 cases and 1159 healthy controls being matched for age and gender.

Association of inorganic arsenic exposure with type 2 diabetes mellitus: a meta-analysis.

Background: The association of long-term effects of inorganic arsenic (iAs) exposure with type 2 diabetes mellitus (T2DM) risk remains controversial.

Methods: A literature search was performed in PubMed, China National Knowledge Infrastructure and Web of Knowledge for relevant available articles published in English or Chinese from 1 January 1990 to 5 June 2013. Case-control, cohort or cross-sectional studies evaluating iAs and T2DM were included.

MicroRNAs dysregulation in epilepsy.

Epilepsy is a syndrome characterized by recurrent spontaneous seizures due to neuronal hyperactivity in the brain. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate post-transcriptional expression of protein-coding mRNAs, which may have key roles in the pathogenesis of neurological disorders. Evidence indicates that miRNAs are emerging as a critical new layer of gene expression regulation with implications for the cause and treatment of epilepsy.

Association between Interleukin-1 gene single nucleotide polymorphisms and ischemic stroke classified by TOAST criteria in the Han population of northern China.

Increasing evidence suggests that IL-1 β (C-511T) and IL-1 α (C-889T) genes polymorphisms are associated with the susceptibility to cardiocerebral vascular disease. In this paper, we investigated the relationships between these polymorphisms and the risk of ischemic stroke (IS) classified by TOAST criteria in the north Chinese Han population. 440 cases of IS and 486 age- and gender-matched controls of Chinese Han population were enrolled.

Black tea, green tea and risk of breast cancer: an update.

Previous meta-analysis indicated conflicting results in case-control versus cohort studies on the association of green tea with breast cancer risk, and conflicting results were also found in case-control versus cohort studies in another meta-analysis on the association of black tea with breast cancer risk. Many studies were published after the previous meta-analysis. Besides, the dose-response relationship of tea consumption with breast cancer risk is unclear.

The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats.

Background: Recent research has indicated that mitochondrial adenosine triphosphate-sensitive potassium channels play an important role in cerebral protection, which involves in attenuating the calcium of mitochondria. However, the effect of diazoxide on cerebral ischemia-reperfusion and the role of spermine, the agonist of mitochondrial calcium uniporter (MCU), remain unknown.

Objective: We investigated the effect of MCU opener spermine on diazoxide against focal cerebral ischemia-reperfusion injury in rats.

Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies.

Objective: We conducted an updated meta-analysis to summarize the evidence from published studies regarding the association of coffee and caffeine intake with breast cancer risk.

Methods: Pertinent studies were identified by a search of PubMed and by reviewing the reference lists of retrieved articles. The fixed or random effect model was used based on heterogeneity test.

Physical activity and risk of breast cancer: a meta-analysis of prospective studies.

We conducted a meta-analysis to summarize the evidence from prospective studies regarding the association between physical activity and breast cancer risk. A comprehensive search was conducted to identify eligible studies. The fixed or random effect model was used based on heterogeneity test.

Vertebral artery dissection associated with viral meningitis.

Background: Vertebral artery dissection (VAD) is often associated with trauma or occurs spontaneously, inevitably causing some neurological deficits. Even though acute infection can be related to the development of spontaneous VAD (sVAD), VAD associated with viral meningitis has never been reported in the literature.

Case Presentation: A 42-year-old man with fever, sore throat, and runny nose developed sudden onset of occipital headache, vertigo, transient confusion, diplopia, and ataxia.

Shotgun proteome expression profile of microdissected superficial transitional cell carcinoma and biomarker discovery from urine.

The aim of this study was to globally characterize the expression profile of superficial transitional cell carcinoma using shotgun proteome strategy and to discuss the biomarker panel identified from urine. We identified 440 commonly expressed proteins from four samples of superficial transitional cell carcinoma using laser capture microdissection coupled with two-dimensional liquid chromatography tandem mass spectrometry. The identified proteins were further analyzed using bioinformatics tools and compared with the published literature.

[The expression of p97 on the membrane of the reticulocyte and the role in iron uptake in rabbit].

Aim: To investigate the expression of p97 on the membrane of the reticulocyte and the possible role in non-transferrin bound iron uptake.

Methods: The SDS-PAGE and the radioisotope (59Fe) was used in this investigation.

Results: (1) The protein of the supernatant of reticulocytes was separated on SDS-PAGE.

[Effect of beta-endorphin on plasma sialic acid level in rats and the relationship with the immune function].

With the use of beta-EP microinjection into the central nervous system, spectrophotometrical analysis and immunochemical method we studied the effect of beta-Endorphin (beta-EP) on plasma sialic acid (SA) level. The results indicate: (1) The plasma SA level was significantly decreased after microinjection of beta-EP into the lateral ventricle (LV); (2) When beta-EP was microinjection into nucleus arcuatus (ARC), the plasma SA level was significantly decreased (P < 0.05).