Furuncular myiasis secondary to Dermatobia hominis.

Dermatobia homininis is the most common cause of furuncular myiasis in Central and South America. It is diagnosed based on a history of travel to an endemic region and the characteristic cutaneous lesion. We present a 54-year-old patient who presented with both a travel history and cutaneous findings of furuncular myiasis.

Human papillomavirus vaccine acceptability among parents of 10- to 15-year-old adolescents.

Objective: To determine human papillomavirus (HPV) vaccine acceptance among parents of 10- to 15-year-old adolescents.

Materials And Methods: Five hundred seventy-five parents or guardians completed a 30-question survey regarding their knowledge of HPV and acceptance of an HPV vaccine. Afterward, subjects read an HPV educational fact sheet and completed a 26-question survey.

Telemedicine network telecolposcopy compared with computer-based telecolposcopy.

Objectives: To compare computer-based telecolposcopy with telemedicine network telecolposcopy.

Materials And Methods: An on-site expert and local clinician at two rural sites conducted colposcopic examinations on 264 women. Colposcopic images were captured and transmitted to two other experts at a remote location using a statewide telemedicine system and a computer and modem-based system.

Interobserver agreement for colposcopy quality control using digitized colposcopic images during the ALTS trial.

Objective: To estimate interobserver agreement among colposcopy quality control reviewers viewing digitized cervical images during the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS).

Materials And Methods: Three colposcopy quality control reviewers independently examined modem-transferred digitized colposcopic images from subjects examined at four clinical centers. Reviewers indicated colposcopic impression, Reid colposcopic index scores, lesion size, and the technical quality of the image.

Screening candidate genes for mutations in patients with hypogonadotropic hypogonadism using custom genome resequencing microarrays.

Objective: The purpose of this study was to determine the consistency of calling single nucleotide polymorphisms (SNPs) by custom genome resequencing microarrays compared with capillary DNA sequencing.

Study Design: Amplified genomic DNA from 23 patients with hypogonadotropic hypogonadism was hybridized to microarrays containing 30 kilobases of sequence from 6 different candidate genes. Capillary DNA sequencing was performed in 10 patients.

Infantile perianal pyramidal protrusion: report of a case and review of the literature.

Infantile perianal pyramidal protrusion is an important, relatively newly recognized condition, which is thought to be under-reported in the pediatric literature. Previous reports refer to these lesions as skin tags or skin folds. More recently, the name infantile perianal pyramidal protrusion has been suggested, based on the characteristic presentation of the lesion in prepubertal children, especially girls.

Cytokine profiles and inflammatory cells during HSV-1-induced acute retinal necrosis.

Purpose: To investigate infiltrating cells, cytokines, and kinetics of cytokine expression during acute retinal necrosis (ARN) in the uninoculated eye after inoculation of herpes simplex virus (HSV)-1 into the anterior chamber of one eye of BALB/c mice.

Methods: At different time points after inoculation of 2 x 10(4) plaque-forming units (PFU) HSV-1 (KOS strain) or an equivalent volume of Vero cell extract in cell culture medium, the uninoculated eyes were enucleated. RT-PCRs for TNFalpha, IFNgamma, and IL-4 and immunohistochemical staining were performed to identify infiltrating cells and cytokines.

BrdU-positive cells in the neonatal mouse hippocampus following hypoxic-ischemic brain injury.

Background: Mechanisms that affect recovery from fetal and neonatal hypoxic-ischemic (H-I) brain injury have not been fully elucidated. The incidence of intrapartum asphyxia is approximately 2.5%, but the occurrence of adverse clinical outcome is much lower.

Curing kinetics of a photo-polymerized dental sealant.

Purpose: To evaluate the effect of using a variety of light-curing sources on the extent (monomer conversion) and rate of cure of a light-cured dental sealant.

Methods: Infrared spectroscopy recorded real-time polymerization of a self-cured and a light-cured sealant when the latter was exposed using manufacturer's recommendations [quartz-tungsten-halogen (QTH)] for 20 seconds as well as to other light sources: high intensity QTH, plasma arc light (PAC), and second-generation blue light emitting diode (LED) units. Specimens were heated to 37 degrees C and the degree and rate of conversion were recorded at each second for 300 seconds.

Ocular reactivation of MCMV after immunosuppression of latently infected BALB/c mice.

Purpose: The purpose of this study was to identify the site(s) of MCMV latency and reactivation in the eye.

Methods: Three months after supraciliary inoculation of 5 x 10(2) PFU of MCMV, BALB/c mice underwent immunosuppression with methylprednisolone and antibodies specific for CD4 T cells, CD8 T cells, and NK cells or with methylprednisolone alone. Control mice were infected but did not receive the immunosuppressants.

Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys.

Rationale: The superior cognitive effects of atypical neuroleptics over typical agents reported in the schizophrenia literature are often attributed to the more prominent antagonist activity of the atypical drugs at serotonin 5HT(2A) receptors. However, atypical neuroleptics also have activity at many additional neurotransmitter receptors and few studies have specifically (and prospectively) tested the hypothesis that 5HT(2A) antagonism alone results in enhanced cognitive function.

Objectives: The purpose of this study was to evaluate the selective 5-HT(2A) antagonist, 7-{4-[2-(4-fluoro-phenyl)-ethyl]-piperazine-1-carbonyl}-1H-indole-3-carbonitrile HCl (EMD 281014) in young and aged monkeys in a test designed to assess working memory function.

Comparative lateralisation patterns in the language area of human, chimpanzee, and rhesus monkey brains.

Lateralised architectural differences in radial cell column structure were detected in the planum temporale of humans but were not found in homologous regions of ape or monkey brains. This study used a new computer imaging method to quantify the architecture of thousands of cortical minicolumns. A study of Lamina III in the left hemisphere of human brains revealed a wider separation between cell columns and more non-neuronal (empty) space within cell columns compared to the right hemisphere.

Successful carbon dioxide laser therapy for refractory anogenital lichen sclerosus.

Background: Lichen sclerosus is a chronic inflammatory dermatitis that often occurs in the anogenital area and presents a therapeutic challenge. Traditional medical management includes potent topical corticosteroids and is marked by variable results.

Objective: The objective was to describe the successful use of carbon dioxide laser ablation therapy in two women with refractory anogenital lichen sclerosus.

Improved potency of escitalopram on the human serotonin transporter: demonstration of an ex vivo assay technique.

The potency of escitalopram ("Lexapro," s-citalopram, LU-26-054) was compared with that of racemic citalopram ("Celexa") using plasma samples from drug-treated normal controls applied to an assay of human serotonin [5-hydroxytryptamine (5-HT)] transport inhibition in blood platelets. Samples were available for both 4-hour and 24-day drug administration. The data indicated that 5-HT transport inhibition was fully manifest for each drug within 4 hours of administration, without significant increase in platelet transport inhibition by 24-day treatment.

Functional MR imaging study of language-related differences in bilingual cerebellar activation.

Background And Purpose: Reports in the monolingual literature suggest that the cerebellum has an important role in language processing. The purpose of this study was to determine whether bilingual cerebellar functional MR imaging (fMRI) activation differs during the performance of comparable tasks in subjects' primary and secondary languages.

Methods: Eight bilingual, right-handed individuals underwent echo-planar fMRI at 1.

Avulsion and partial matricectomy with the carbon dioxide laser for pincer nail deformity.

Background: Pincer nail deformity is a common nail disorder that sometimes necessitates surgical intervention. A multitude of therapeutic modalities has been implemented to treat this condition.

Objective: To describe the use of the carbon dioxide laser in the successful treatment of pincer nail deformity.

Domestic violence in the outpatient setting.

Domestic abuse is a serious problem that may present directly or indirectly in the clinical setting. The astute physician may have the opportunity to directly intervene in this national dilemma. We present a patient who indirectly sought help through the medical setting, review the physician's responsibilities, and offer guidelines for management.

Comparison of direct digital and conventional intraoral radiographs in detecting alveolar bone loss.

Background: Intraoral radiographs are important diagnostic aids in periodontics. The authors conducted a study to compare estimates of bone levels from direct digital and conventional radiographic under normal clinical use.

Methods: A full-mouth series of conventional radiographs was taken for each of 25 subjects who had periodontitis.