Efficacy and safety of acotiamide for the treatment of functional dyspepsia: systematic review and meta-analysis.

Background: There are no treatments with established efficacy for this disorder so far.

Aim: To systematically review the efficacy of acotiamide in the treatment of patients with FD.

Methods: We searched main electronic databases through November 2013.

Influence of the core circadian gene "Clock" on obesity and leptin resistance in mice.

Alterations in metabolism could be due to cell-autonomous effects associated with altered expression of Clock in central nervous system feeding centers and/or peripheral tissues involved in metabolism. Clock mutant mice are hyperphagic and obese, which indicates that Clock is related to obesity. In the present study, we used intracerebroventricular injection of recombinant adenoviral vector harboring Clock genes to explore the role of Clock on diet induced obesity and the mechanisms involved in leptin resistance and leptin signaling in mice.