Imipramine-Induced Cutaneous and Iris Hyperpigmentation: A Case Report and Literature Review.

To describe a novel case of imipramine-induced hyperpigmentation and characterize the literature pertaining to imipramine-induced hyperpigmentation to this point. PubMed and Google Scholar were searched through July 2021 utilizing various combinations of , , and . The references of initial articles were searched for more case reports and imipramine-related literature.

Extra-synaptic modulation of GABA and efficacy in bipolar disorder.

Background: Bipolar disorder type I is a severe psychiatric condition that leads to significant morbidity and mortality and whose treatment remains suboptimal. Its pathophysiology involves disturbance in the control of ionic fluxes so that when patients are either manic or depressed, the resting membrane potential of neurons is more depolarized than normal. Available mood stabilizers have a shared mechanism of normalizing ion flux by compensating for ionic abnormalities, and normalizing membrane potential.