102 results match your criteria: "The London Chest Hospital[Affiliation]"
Purpose: The main objective of this study was to develop two-dimensional (2D) phase contrast (PC) methods to quantify the helicity and vorticity of blood flow in the aortic root.
Methods: This proof-of-concept study used four-dimensional (4D) flow cardiovascular MR (4D flow CMR) data of five healthy controls, five patients with heart failure with preserved ejection fraction and five patients with aortic stenosis (AS). A PC through-plane generated by 4D flow data was treated as a 2D PC plane and compared with the original 4D flow.
Impact of afterload and infiltration on coexisting aortic stenosis and transthyretin amyloidosis.
Heart
January 2022
Institute of Cardiovascular Science, University College London, London, UK.
Article Synopsis
- The study investigated the impact of wild-type transthyretin cardiac amyloidosis (ATTR) on patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI), identifying diagnostic and management challenges.
- Researchers analyzed data from 583 patients, comparing groups with AS, ATTR, AS-ATTR, and age-matched controls, assessing factors like cardiac remodeling and function using NT-proBNP as a main measurement.
- Results showed that patients with AS-ATTR experienced more severe cardiac issues compared to those with just AS, suggesting that the combined condition is at an early stage of amyloid infiltration, yet still resembles more advanced ATTR complications, indicating potential benefits from ATTR-targeted treatments.
Foreword.
Interv Cardiol
November 2019
Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Foreword.
Interv Cardiol
May 2019
Interventional cardiologist and TAVI operator at Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Foreword.
Interv Cardiol
February 2019
Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Foreword.
Interv Cardiol
May 2018
Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
2017 and all that.
Interv Cardiol
January 2018
Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Foreword.
Interv Cardiol
September 2017
Simon Kennon is an Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Foreword.
Interv Cardiol
May 2017
Simon Kennon is an Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Cochrane Corner: stem cell therapy for chronic ischaemic heart disease and congestive heart failure.
Heart
January 2018
Barts and the London NHS Trust, The London Chest Hospital, London, UK.
One-year outcomes after successful chronic total occlusion percutaneous coronary intervention: The impact of dissection re-entry techniques.
Catheter Cardiovasc Interv
November 2017
Forth Valley Royal Hospital, Larbert, United Kingdom.
We aimed to determine clinical outcomes 1 year after successful chronic total occlusion (CTO) PCI and, in particular, whether use of dissection and re-entry strategies affects clinical outcomes. Hybrid approaches have increased the procedural success of CTO percutaneous coronary intervention (PCI) but longer-term outcomes are unknown, particularly in relation to dissection and re-entry techniques. Data were collected for consecutive CTO PCIs performed by hybrid-trained operators from 7 United Kingdom (UK) centres between 2012 and 2014.
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Interv Cardiol
October 2016
Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Cocoa flavanols reduce N-terminal pro-B-type natriuretic peptide in patients with chronic heart failure.
ESC Heart Fail
June 2016
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London Charterhouse Square London EC1M 6BQ UK.
Aims: Poor prognosis in chronic heart failure (HF) is linked to endothelial dysfunction for which there is no specific treatment currently available. Previous studies have shown reproducible improvements in endothelial function with cocoa flavanols, but the clinical benefit of this effect in chronic HF has yet to be determined. Therefore, the aim of this study was to assess the potential therapeutic value of a high dose of cocoa flavanols in patients with chronic HF, by using reductions in N-terminal pro-B-type natriuretic peptide (NT-proBNP) as an index of improved cardiac function.
View Article and Find Full Text PDFHybrid approach improves success of chronic total occlusion angioplasty.
Heart
September 2016
Golden Jubilee National Hospital, Glasgow, UK Edinburgh Heart Centre, Edinburgh, UK Forth Valley Acute Hospitals, Larbert, UK.
Objectives: Treatment options for coronary chronic total occlusions (CTO) are limited, with low historical success rates from percutaneous coronary intervention (PCI). We report procedural outcomes of CTO PCI from 7 centres with dedicated CTO operators trained in hybrid approaches comprising antegrade/retrograde wire escalation (AWE/RWE) and dissection re-entry (ADR/RDR) techniques.
Methods: Clinical and procedural data were collected from consecutive unselected patients with CTO between 2012 and 2014.
Foreword.
Interv Cardiol
May 2016
Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Lung Deflation and Cardiovascular Structure and Function in Chronic Obstructive Pulmonary Disease. A Randomized Controlled Trial.
Am J Respir Crit Care Med
April 2016
2 William Harvey Research Institute, Queen Mary University of London, London, United Kingdom; and.
Rationale: Patients with chronic obstructive pulmonary disease develop increased cardiovascular morbidity with structural alterations.
Objectives: To investigate through a double-blind, placebo-controlled, crossover study the effect of lung deflation on cardiovascular structure and function using cardiac magnetic resonance.
Methods: Forty-five hyperinflated patients with chronic obstructive pulmonary disease were randomized (1:1) to 7 (maximum 14) days inhaled corticosteroid/long-acting β2-agonist fluticasone furoate/vilanterol 100/25 μg or placebo (7-day minimum washout).
Foreword.
Interv Cardiol
September 2015
Interventional Cardiologist and TAVI Operator at the Barts Heart Centre, St Bartholomew's Hospital, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Sudden adult death syndrome in m.3243A>G-related mitochondrial disease: an unrecognized clinical entity in young, asymptomatic adults.
Eur Heart J
August 2016
Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
Aims: To provide insight into the mechanism of sudden adult death syndrome (SADS) and to give new clinical guidelines for the cardiac management of patients with the most common mitochondrial DNA mutation, m.3243A>G. These studies were initiated after two young, asymptomatic adults harbouring the m.
View Article and Find Full Text PDFFractal Analysis of Myocardial Trabeculations in 2547 Study Participants: Multi-Ethnic Study of Atherosclerosis.
Radiology
December 2015
From the Division of Cardiovascular Imaging and Biostatistics, The Heart Hospital, 16-18 Westmoreland Street, London, England, W1G 8PH (G.C., P.B., W.J.M., P.M.E., J.C.M.); UCL Institute of Cardiovascular Science, University College London, London, England (G.C., V.M., W.J.M., P.M.E., J.C.M.); Cardiovascular Biomedical Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, England (F.Z., S.E.P.); Division of Cardiovascular Imaging, The London Chest Hospital, London, England (F.Z., S.E.P.); UCL Center for Cardiovascular Imaging and Great Ormond Street Hospital for Children, London, England (V.M.); Department of Radiology, University of Pennsylvania, Philadelphia, Pa (C.L.); Department of Radiology, Hospital Graubuenden, Loestrasse, Switzerland (N.K.B.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (J.A.C.L., D.A.B.); and Department of Cardiovascular Imaging, Johns Hopkins Hospital, Baltimore, Md (D.A.B.).
Purpose: To quantitatively determine the population variation and relationship of left ventricular (LV) trabeculation to LV function, structure, and clinical variables.
Materials And Methods: This HIPAA-compliant multicenter study was approved by institutional review boards of participating centers. All participants provided written informed consent.
Time-trend analyses of bleeding and mortality after primary percutaneous coronary intervention during out of working hours versus in-working hours: an observational study of 11 466 patients.
Circ Cardiovasc Interv
June 2015
From the Department of Cardiology, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Middlesex, United Kingdom (M.B.I., C.I., M.D.); Department of Cardiology, Victoria Heart Institute Foundation, Victoria, British Columbia, Canada (M.B.I.); Department of Cardiology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom (R.K., G.M., I.S.M.); Department of Cardiology, UCL Hospitals NHS Foundation Trust, Heart Hospital, London, United Kingdom (T.C., P. Meier); Department of Cardiology, St. George's Healthcare NHS Foundation Trust, St. George's Hospital, London, United Kingdom (S.F., P.L.); Department of Cardiology, Kings College Hospital, King's College Hospital NHS Foundation Trust, London, United Kingdom (S.K., P. MacCarthy); Department of Cardiology, Barts Health NHS Trust, The London Chest Hospital, Bonner Road, London, United Kingdom (C.K., A.A., A.M., D.B., K.R., D.A.J., A.W.); Department of Cardiology, Royal Free London NHS Foundation Trust, London, United Kingdom (R.D.R.); Department of Cardiology, BHF Centre of Excellence, Kings College London, St. Thomas' Hospital, London, United Kingdom (S.R.); and Department of Cardiology, London Ambulance Service, London, United Kingdom (M.W.).
Background: Primary percutaneous coronary intervention (PPCI) is the treatment of choice for ST-segment-elevation myocardial infarction. Resources are limited during out of working hours (OWH). Whether PPCI outside working hours is associated with worse outcomes and whether outcomes have improved over time are unknown.
View Article and Find Full Text PDFDifferent Imaging Strategies in Patients With Possible Basilar Artery Occlusion: Cost-Effectiveness Analysis.
Stroke
July 2015
From the Institute of Clinical Radiology (S.E.B., B.E.-W., M.F.R., W.H.S.), Department of Neurology (F.S., L.B.), Institute for Stroke and Dementia Research (M.D.), and Department of Neuroradiology (H.J.), Ludwig-Maximilian University of Munich Hospitals, Munich, Germany; Advanced Cardiovascular Imaging, William Harvey Research Institute, National Institute for Health Research, Cardiovascular Biomedical Research Unit at Barts, The London Chest Hospital, London, United Kingdom (S.E.P.); Department of Radiology (M.G.H.) and Department of Epidemiology (M.G.H.), Erasmus University Medical Center, Rotterdam, The Netherlands; and Department of Health Policy and Management, Harvard School of Public Health, Harvard University, Boston, MA (M.G.H.).
Background And Purpose: This study evaluated the cost-effectiveness of different noninvasive imaging strategies in patients with possible basilar artery occlusion.
Methods: A Markov decision analytic model was used to evaluate long-term outcomes resulting from strategies using computed tomographic angiography (CTA), magnetic resonance imaging, nonenhanced CT, or duplex ultrasound with intravenous (IV) thrombolysis being administered after positive findings. The analysis was performed from the societal perspective based on US recommendations.
Foreword.
Interv Cardiol
May 2015
Interventional Cardiologist and Head of the Transcatheter Aortic Valve Implantation Programme at the London Chest Hospital, Barts Health NHS Trust, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.
Image quality and radiation dose of a prospectively electrocardiography-triggered high-pitch data acquisition strategy for coronary CT angiography: The multicenter, randomized PROTECTION IV study.
J Cardiovasc Comput Tomogr
March 2016
Medizinische Klinik und Poliklinik I der Ludwig-Maximilians-Universität München, Marchioninistr 15, Munich 81377, Germany. Electronic address:
Background: Concerns have been raised about radiation dose of coronary CT angiography. Although high-pitch acquisition technique yields high potential for radiation dose savings, it is more vulnerable to artifacts, which impair diagnostic image quality.
Objective: The purpose of this study was to compare 2 scan strategies for coronary CT angiography: a high-pitch helical scan first or a conventional scan first strategy.
Almanac 2014: cardiomyopathies.
Turk Kardiyol Dern Ars
April 2015
Inherited Cardiac Diseases Unit, The Heart Hospital, University College London, London, UK.
Cardiomyopathies are myocardial disorders that are not explained by abnormal loading conditions and coronary artery disease. They are classified into a number of morphological and functional phenotypes that can be caused by genetic and non-genetic mechanisms. The dominant themes in papers published in 2012-2013 are similar to those reported in Almanac 2011, namely, the use (and interpretation) of genetic testing, development and application of novel non-invasive imaging techniques and use of serum biomarkers for diagnosis and prognosis.
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Interv Cardiol
March 2015
Interventional Cardiologist and Head of the Transcatheter Aortic Valve Implantation Programme at the London Chest Hospital, Barts Health NHS Trust, London. He trained at Manchester University, St Bartholomew's Hospital, the London Chest Hospital and St Vincent's Hospital, Melbourne. His research interests relate to aortic valve and coronary interventions.