108 results match your criteria: "The London Breast Institute[Affiliation]"
Cancers (Basel)
June 2023
The London Breast Institute, Princess Grace Hospital, London W1U 5NY, UK.
Recent advances in systemic treatment for breast cancer have been underpinned by recognising and exploiting subtype-specific vulnerabilities to achieve higher rates of pathologic complete response (pCR) after neo-adjuvant systemic therapy (NAST). This down-staging of disease has permitted safe surgical de-escalation in patients who respond well. Triple-negative (TNBC) or HER2-positive breast cancer is most likely to achieve complete radiological response (rCR) and pCR after NAST.
View Article and Find Full Text PDFCancers (Basel)
December 2022
The London Breast Institute, Princess Grace Hospital, London W1U 5NY, UK.
Contrary to traditional assumptions, recent evidence suggests that neoadjuvant systemic therapy (NST) given for invasive breast cancer may eradicate co-existent ductal carcinoma in-situ (DCIS), which may facilitate de-escalation of breast resections. The aim of this systematic review was to assess the eradication rate of DCIS by NST given for invasive breast cancer. Searches were performed in MEDLINE using appropriate search terms.
View Article and Find Full Text PDFBreast Cancer Res Treat
November 2022
The London Breast Institute, Princess Grace Hospital, London, W1U 5NY, UK.
Int J Mol Sci
August 2022
Centre for Genome Engineering and Maintenance, Institute for Health Medicine and Environments, Brunel University London, Uxbridge UB8 3PH, UK.
overexpression has previously been found to correlate with worse prognosis for breast cancer patients and, as an incredibly diverse protein in both function and cellular localisation, ACBD3 may have a larger role in breast cancer than previously thought. This study further investigated ACBD3's role in breast cancer. Bioinformatic databases were queried to characterise expression and mutation in breast cancer and to investigate how overexpression affects breast cancer patient outcomes.
View Article and Find Full Text PDFCancers (Basel)
July 2022
Department of Research and Innovations, Datar Cancer Genetics, Nasik 422010, India.
Background: The early detection of breast cancer (BrC) is associated with improved survival. We describe a blood-based breast cancer detection test based on functional enrichment of breast-adenocarcinoma-associated circulating tumor cells (BrAD-CTCs) and their identification via multiplexed fluorescence immunocytochemistry (ICC) profiling for GCDFP15, GATA3, EpCAM, PanCK, and CD45 status.
Methods: The ability of the test to differentiate BrC cases ( = 548) from healthy women ( = 9632) was evaluated in a case-control clinical study.
Genes (Basel)
February 2022
Centre for Genome Engineering and Maintenance, Institute for Health Medicine and Environments, Brunel University London, Uxbridge UB8 3PH, UK.
Breast tumour kinase (Brk/PTK6) is overexpressed in up to 86% of breast cancers and is associated with poorer patient outcomes. It is considered a potential therapeutic target in breast cancer, even though the full spectrum of its kinase activity is not known. This study investigated the role of the kinase domain in promoting tumour growth and its potential in sensitising triple negative breast cancer cells to standard of care chemotherapy.
View Article and Find Full Text PDFAnticancer Res
February 2022
The London Breast Institute, Princess Grace Hospital, London, U.K.
Background/aim: Improvements in acellular dermal matrix (ADM) and surgical techniques have facilitated pre-pectoral immediate breast reconstruction (IBR). Outer shell texturing is a key risk factor for anaplastic large cell lymphoma, prompting this evaluation of reconstruction with nano-textured rounded implants.
Patients And Methods: Fifty-one consecutive patients underwent 72 pre-pectoral ADM-assisted (fenestrated SurgiMend™) IBRs using nano-textured implants (Sebbin™).
Anticancer Res
February 2022
The London Breast Institute, Princess Grace Hospital, London, U.K.
Breast cancer is the most common cancer in women globally. To prevent relapse and prolong disease-free survival, adjuvant endocrine treatment such as selective oestrogen receptor modulators and aromatase inhibitors are being used. However, such oestrogen-blocking agents can cause serious adverse events.
View Article and Find Full Text PDFBreast
August 2021
The London Breast Institute, Princess Grace Hospital, London, W1U 5NY, UK.
Cancers (Basel)
May 2021
The London Breast Institute, Princess Grace Hospital, London W1U 5NY, UK.
Wire-guided localisation (WGL) has been the mainstay for localising non-palpable breast lesions before excision. Due to its limitations, various wireless alternatives have been developed. In this prospective study, we evaluate the role of radiation-free wireless localisation using the SAVI SCOUT system at the London Breast Institute.
View Article and Find Full Text PDFCancers (Basel)
March 2021
The London Breast Institute, The Princess Grace Hospital, London W1U 5NY, UK.
Targeted axillary dissection (TAD) is a new axillary staging technique that consists of the surgical removal of biopsy-proven positive axillary nodes, which are marked (marked lymph node biopsy (MLNB)) prior to neoadjuvant chemotherapy (NACT) in addition to the sentinel lymph node biopsy (SLNB). In a meta-analysis of more than 3000 patients, we previously reported a false-negative rate (FNR) of 13% using the SLNB alone in this setting. The aim of this systematic review and pooled analysis is to determine the FNR of MLNB alone and TAD (MLNB plus SLNB) compared with the gold standard of complete axillary lymph node dissection (cALND).
View Article and Find Full Text PDFJ Invest Surg
February 2022
The London Breast Institute, Princess Grace Hospital, London, UK.
Background: Autologous fat grafting (AFG) is a recognized surgical procedure to correct deformities following breast conservation surgery (BCS) for breast cancer. However, there are concerns about the oncological safety of this technique. In this study we have reviewed the current literature to assess whether AFG adversely influences the oncological outcome after BCS for breast cancer.
View Article and Find Full Text PDFJ Plast Reconstr Aesthet Surg
May 2021
The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London, W1U 5NY, UK.
Lancet Oncol
November 2020
The London Breast Institute, Princess Grace Hospital, London W1U 5NY, UK. Electronic address:
Anticancer Res
July 2020
The London Breast Institute, the Princess Grace Hospital, London, U.K.
Background: Wire-guided localization (WGL) has been the mainstay for localizing non-palpable breast lesions before excision. Due to its limitations, various wireless alternatives have been developed. In this prospective study, we evaluate the role of radiation-free wireless localization using the SAVI SCOUT® localization at a European centre.
View Article and Find Full Text PDFAnticancer Res
July 2020
The London Breast Institute, The Princess Grace Hospital, London, U.K.
Background/aim: With the increase in detection of non-palpable breast lesions through screening, wire-guided localisation (WGL) has long been the favoured method for preoperative localisation. However, this technique comes with several limitations. New methods have been developed, including several non-radioactive, wireless options.
View Article and Find Full Text PDFCancer Genomics Proteomics
September 2020
The London Breast Institute, Princess Grace Hospital, London, U.K.
Background/aim: In this study, we aimed to investigate the prognostic role of a previously identified panel of 10 stem cell markers stratified against the catalytic subunit of telomerase (hTERT) in human breast cancer.
Materials And Methods: The mRNA copy numbers of these genes were determined using real time quantitative PCR in 124 breast cancer tissues and adjacent non-cancerous tissues. Relations between mRNA levels and survival were analysed using Kaplan-Meier plots and Cox regression analysis.
Sci Rep
February 2020
The London Breast Institute, Princess Grace Hospital, London, UK.
Patients presenting with de novo stage IV metastatic breast cancer have a complex disease which is normally treated with palliative intent and systemic therapy. However, there is mounting evidence that resection of the primary tumour and/or localised radiotherapy (locoregional therapy; LRT) could be associated with overall survival improvements. We aimed to conduct a meta-analysis to inform decision making.
View Article and Find Full Text PDFAm J Surg
August 2020
King's College Hospital NHS Foundation Trust, London, UK. Electronic address:
Background: Oncoplastic Breast Conserving Surgery (OBCS) allows adequate resection margins of tumours unsuitable for standard breast conserving surgery (SBCS) whilst allowing for better cosmesis and reduced morbidity when compared to mastectomy. However, there is limited evidence on its oncological safety.
Methods: This study aims to compare oncological safety of OBCS with SBCS and mastectomy by examining the relative risk of cancer recurrence and re-operation rates through meta-analysis.
Anticancer Res
January 2020
The London Breast Institute, The Princess Grace Hospital, London, U.K.
Background: Wire-guided localisation (WGL) remains the most widely used technique to guide surgical excision of non-palpable breast lesions worldwide. However, recent technological advances have led to the advent of less invasive radiation-free localisation methods to overcome the limitations of WGL.
Patients And Methods: This study prospectively evaluated the role of two radiation-free non-wire localisation methods.
In Vivo
June 2020
The London Breast Institute, Princess Grace Hospital, London, U.K.
Background/aim: Wire-guided localisation (WGL) has been the mainstay for localisation of clinically occult breast lesions before excision. However, it has restrictive scheduling requirements, and causes patient discomfort. This has prompted the development of various wireless alternatives.
View Article and Find Full Text PDFAnticancer Res
October 2019
The London Breast Institute, Princess Grace Hospital, London, U.K.
Background/aim: Prostate cancer is one of the most common cancers in men which remains a global public health issue. Treatment of prostate cancer is becoming increasingly intensive and aggressive, with a corresponding increase in resistance, toxicity and side effects. This has revived an interest in nontoxic and cost-effective preventive strategies including dietary compounds due to the multiple effects they have been shown to have in various oncogenic signalling pathways, with relatively few significant adverse effects.
View Article and Find Full Text PDFIn Vivo
January 2020
The London Breast Institute, Princess Grace Hospital, London, U.K.
Background/aim: Bisphenol A (BPA) is a ubiquitous substance found in a wide array of consumer products and healthcare consumables, and at low doses in drinking water. Currently, in the UK, it is classed as a low-risk substance with little potential for harm. It has been known to have effects on oestrogen receptors.
View Article and Find Full Text PDFIn Vivo
December 2019
The London Breast Institute, Princess Grace Hospital, London, U.K.
Numerous dietary components and vitamins have been found to inhibit the molecular events and signalling pathways associated with various stages of breast cancer development. To identify the vitamins and dietary micronutrients that exert protective effects against breast cancer and define their mechanism of action, we performed a literature review of in vitro, animal and epidemiological studies and selected the in vitro and animal studies with robust molecular evidence and the epidemiological studies reporting statistically significant inverse associations for a breast cancer-specific protective effect. There is sufficient evidence from in vitro, animal and epidemiological human studies that certain vitamins, such as vitamin D3, folate, vitamin B6, and beta carotene as well as dietary micronutrients, such as curcumin, piperine, sulforaphane, indole-3-carbinol, quercetin, epigallocatechin gallate (EGCG) and omega-3 polyunsaturated fatty acids (PUFAs), display an antitumoral activity against breast cancer and have the potential to offer a natural strategy for breast cancer chemoprevention and reduce the risk of breast cancer recurrence.
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