6 results match your criteria: "The Latin America Sepsis Institute[Affiliation]"

The aim of this study was to develop evidence-based recommendations for the diagnosis and treatment of sepsis in children in low- and middle-income countries (LMICs), more specifically in Latin America. A panel was formed consisting of 27 experts with experience in the treatment of pediatric sepsis and two methodologists working in Latin American countries. The experts were organized into 10 nominal groups, each coordinated by a member.

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Sepsis, defined as infection with associated organ dysfunction, accounts for most childhood deaths due to infection globally. Evidence for the optimal support of children with septic shock refractory to the initial sepsis management bundle remains minimal. There is an urgent need for more effective interventions.

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Article Synopsis
  • The objective was to create evidence-based guidelines for clinicians treating children with septic shock and related organ dysfunction.
  • A diverse panel of 49 international experts was assembled, including specialists from various organizations, to collaboratively review and discuss the management of septic conditions in children.
  • The panel produced 77 management statements, categorizing them as six strong recommendations, 52 weak ones, and nine best practice suggestions based on existing, though inconclusive, evidence.
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Article Synopsis
  • The objective of the study was to create evidence-based recommendations for clinicians treating children with septic shock and related organ dysfunction, involving a global panel of 49 experts.
  • The guideline development process included thorough discussions via teleconferences and dedicated meetings, ensuring that a conflict-of-interest policy was strictly followed throughout.
  • As a result, 77 management statements were developed, with six classified as strong recommendations and the majority as weak, highlighting the complexity and variability in clinical practice for these conditions.
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