Serum concentrations of remnant-like particles in hypothyroid patients before and after thyroxine replacement.

Objectives: Remnant-like particles (RLPs) reflect chylomicron remnants and very-low-density lipoprotein remnants, which are most likely to be atherogenic particles. To investigate the effect of thyroxine replacement on the metabolism of RLPs in hypothyroidism, we measured serum concentrations of RLPs during an oral fat-loading test in patients with hypothyroidism before and after thyroxine replacement.

Patients And Methods: Thirteen patients with hypothyroidism, having serum-free thyroxine (FT4) of 4.