4 results match your criteria: "The Jiangyin Hospital Affiliated to Medical College of Southeast University[Affiliation]"
Paclitaxel Resistance Modulated by the Interaction between TRPS1 and AF178030.2 in Triple-Negative Breast Cancer.
Evid Based Complement Alternat Med
March 2022
Department of Oncology, The Jiangyin Hospital Affiliated to Medical College of Southeast University, 163th Shoushan Road, Jiangyin, Wuxi, Jiangsu 214400, China.
Paclitaxel is a chemotherapeutic agent that acts as an inhibitor of cellular mitosis and has been widely used in the treatment of triple-negative breast cancer (TNBC). However, paclitaxel resistance is one of the major reasons that contribute to the high failure rates of chemotherapy and the relapse of TNBC. Accumulating studies have demonstrated that long noncoding RNA (lncRNA) plays a role in the paclitaxel resistance and positively correlated with progression and metastasis of breast cancers.
View Article and Find Full Text PDFOverexpression of CTEN is associated with gefitinib resistance in non-small cell lung cancer.
Oncol Lett
January 2021
Department of Oncology, The Jiangyin Hospital Affiliated to Medical College of Southeast University, Jiangyin, Jiangsu 214400, P.R. China.
COOH-terminus tensin-like molecule (CTEN) is a member of the tensin family, which is considered to be one of the novel proto-oncogenes involved in tumorigenesis and cancer progression. However, the mechanisms of CTEN in acquired resistance of non-small cell lung cancer (NSCLC) remain relatively unknown. The aim of the present study was to understand the roles of CTEN in acquired gefitinib resistance of NSCLC.
View Article and Find Full Text PDFCTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells.
PLoS One
December 2018
Department of Oncology, The Jiangyin Hospital Affiliated to Medical College of Southeast University, Jiangyin, P.R.China.
To explore the effects and mechanism of CTEN (COOH-terminus tensin-like molecule) on EMT, cell migration and invasion of Human lung adenocarcinoma cells. The pCMV-vector, pCMV-CTEN, Control-shRNA, and CTEN-shRNA were transfected into A549 and NCI-H1299 cells by Lipofectamine 2000. Transforming growth factor-β1(TGF-β1)and epithelial-mesenchymal transition (EMT) -related biomarkers were detected by eliseand western blot.
View Article and Find Full Text PDFOsterix Decreases the Chemosensitivity of Breast Cancer Cells by Upregulating GALNT14.
Cell Physiol Biochem
January 2018
Department of Developmental Genetics, Nanjing Medical University, Nanjing, China.
Background/aims: Osterix (Osx), a key regulator of osteoblast differentiation and bone formation, has been recently reported to be associated with the progression of breast cancer. However, the precise roles of Osx in breast cancer remain unclear.
Methods: Drug sensitivity of the cancer cells was assessed using an 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay.