Preparation and Characterization of Essential oil from Lavandula spica Plant and its Antimicrobial Activity against Pseudomonas aeruginosa and Staphylococcus aureus.

The biological properties of herbs and essential oils (EOs), such as their antibacterial, analgesic, anti-inflammatory, antioxidant, and anticancer characteristics, make them widely used in a variety of fields. This research aims to assess the antibacterial efficacy of lavender oil against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P.

Preparation and Evaluation of pH-Sensitive Chitosan/Alginate Nanohybrid Mucoadhesive Hydrogel Beads: An Effective Approach to a Gastro-Retentive Drug Delivery System.

Background: Despite extensive research over the decades, cancer therapy is still a great challenge because of the non-specific delivery of chemotherapeutic agents, which could be overcome by limiting the distribution of chemotherapeutic agents toward cancer cells.

Objective: To reduce the cytolytic effects against cancer cells, graphene oxide (GO) nanoparticles (NPs) can load anticancer medicines and genetic tools.

Methodology: During the current study, folic-acid-conjugated graphene oxide (Fa-GO) hybrid mucoadhesive chitosan (CS)-based hydrogel beads were fabricated through an "ion-gelation process", which allows for regulated medication release at malignant pH.

Therapeutic Potential of Novel Silver Carbonate Nanostructures in Wound Healing and Antibacterial Activity Against and .

: Metallic NPs have been explored for various therapeutic uses owing to utilitarian physicochemical characteristics such as antibacterial, anti-inflammatory, and healing properties. The objective of this study is to evaluate the therapeutic potential of novel silver carbonate nanostructures in promoting wound healing and their antibacterial activity against and . : In this work, we prepared AgCO nanoparticles through a two-step methodology that was expected to improve the material's biomedical performance and biocompatibility.

Nutraceutical tablets: Manufacturing processes, quality assurance, and effects on human health.

Consumers are increasingly focused on food products' nutritional content and health aspects. Nutraceutical tablets containing nutritional supplements have seen remarkable progress and are well-known for their precise dosage, which can improve consumer health by increasing the intake of bioactive compounds and vital nutrients. Oral nutraceuticals are frequently used to enhance consumer well-being, with around 80% of products being in solid form.

Evaluating the Influence of Different Artificial Diets on L. Using Health Biomarkers and Performance Metrics.

The diet of L. is a crucial factor for managing its colonies particularly during dearth periods. Numerous diets have been developed; however, their global implementation faces challenges due to diverse climatic conditions and some other factors.

Exploration of newly synthesized deferasirox derivatives as potential anti-cancer agents via in-vitro and in-silico approaches.

Carbonic anhydrase IX (CA IX), upregulated by hypoxia-inducible factor (HIF), plays a crucial role in regulation of intracellular and extracellular pH, which is essential for the growth and spread of tumors. The overexpression of CA IX in breast cancer is linked to a low post-radiation patient survival rate. Under normoxic conditions, CA IX expression is relatively low, but hypoxia-inducible factors (HIFs) upregulate its expression when oxygen levels drop.

Synthesis and characterization of fluorenone derivatives with electrical properties explored using density functional theory (DFT).

This study provides thorough computational and experimental assessments of four types of novel synthesized thiosemicarbazones. The compounds were effectively synthesized using a condensation reaction between thiosemicarbazide and fluorenone, producing a remarkable range of 70-88%. Additional chemical structures were examined utilizing spectroscopic methods, including Fourier-transform infrared spectroscopy (FTIR), NMR spectroscopy, and ultraviolet-visible spectroscopy.

Validation of SSR markers for identification of high-yielding and Phytophthora Capsici root rot resistant chilli genotypes.

The study was designed to validate the previously reported 34 SSR markers using 78 chilli genotypes to detect significant trait specific markers as well as superior genotypes resistant to Phytophthora capsici root rot (PcRR). In this context, the identification of germplasm with higher yield per plant (YPP) leads to hype in stress tolerance index (STI) in genotypes, Chakwal3 (11.98), Greenfire (10.

The Complex Relationship Between Chronic Obstructive Pulmonary Disease With Cardiovascular Disease and Their Interactions With COVID-19 Vaccination: A Retrospective Study.

Background: Previously, most researchers explored the association between chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). This study investigates the distinct influence of COVID-19 vaccination status on patients with both conditions.

Objective: We investigate the relationship between COPD and CVD in a cohort of 838 individuals who presented with both conditions.

Putting forward novel sulfonamide-thiazole-pyrazoline hybrids as potential central core structure for the development of non-specific b-TNAP and c-IAP inhibitors.

Alkaline phosphatases (ALPs) play crucial role in various functions of human body, such as bone formation, metabolism in liver and intestines, and transfer of nutrients from mother to fetus during pregnancy. However, their overexpression is associated with severe consequences in different patients, such as deposition of minerals in dialysis patients also called coronary calcification and increased bone turnover in patients facing cancer metastization. Due to their involvement in crucial functions of human body and association with such harsh consequences, there is need of newer efficient ALP inhibitors that can tackle ALP excess without derailing the progress of normal functions.

Conservation agriculture effects on ecosystem health and sustainability - A review of rice-wheat cropping system.

Conventional tillage, extreme climate events, increasing weed incidence, pest and disease pressures, and diminished farm input availability negatively impact crop yield, stability, profitability, and water productivity in South Asia's rice-wheat (R-W) systems. This article reviews and evaluates the effectiveness and benefits of conservation agriculture (CA) practices in improving soil health, water productivity, and sustainability in R-W systems. CA practices focus on minimum soil disturbance, permanent soil cover, and crop rotations.

Does Despotic Leadership Impact Employees' Career success: The Parallel Mediation Framework.

Drawing on the conservation of resource (COR) theory principles, this study demonstrates how despotic leadership (DL) negatively impacts employee career success (ECS) in the pharmaceutical industry. Since this is a serious growing concern in emerging research and a threat to the career therefore we aimed to investigate the relationship between (DL) and (ECS). Parallel mediating effects of job insecurity (JI) and emotional exhaustion (EE) are also tested which was overlooked in previous literature.

Unleashing the synergistic effect of promising fungicides: a breakthrough solution for combating powdery mildew in pea plants.

Pea powdery mildew, caused by , is a major limitation to global pea production. The emergence of fungicide-resistant pathogen populations due to frequent and injudicious pesticide application highlights the importance of exploring the synergistic properties of fungicide combinations. This study investigated the efficacy of difenoconazole, thiophanate-methyl, and sulfur, both individually and in mixtures, against powdery mildew and assessed the interaction types between these fungicides.

Welfare assessment of dromedary camels kept under pastoralism in Pakistan.

Standardized welfare assessment protocols are crucial to enhance animal welfare; up to date, there is no data on the level of welfare of camels kept under pastoralism. A tailored protocol for measuring welfare in dromedary camels kept under nomadic pastoralist conditions was recently developed, drawing from the currently available welfare protocol for dromedary camels kept in intensive systems. This study, therefore, aimed to apply the newly developed tailored protocol and assess the welfare of dromedary camels kept under pastoralism in the Southern Punjab Province of Pakistan.

Antioxidant and renal protective effects of Nano-selenium on adenine-induced acute renal failure in canines.

Acute renal failure is a common clinical disease in canines, affecting antioxidant levels and decreasing the body's resistance. This study aims to explore the therapeutic mechanism of Nano-selenium in acute renal failure. The histopathological and imaging changes of kidney tissue were observed with the gene and protein expression levels of Keap1, Nrf2, HO-1, and NQO1 in the kidney.

Associations between and polymorphisms and thalassemia risk.

Objectives: This study investigated the associations of the rs4671393, rs1427407, and rs11886868 genetic variants of the gene and the rs9399137 variant of the gene with thalassemia in patients from the population of Punjab, Pakistan.

Methods: A cohort of 600 participants, comprising 300 patients with thalassemia and 300 age- and sex-matched healthy controls, was recruited from various hospitals in Punjab, Pakistan. DNA was extracted from whole blood samples from all participants.

Nutritional composition, bioactive compounds and antioxidant potentiality of some indigenous vegetables consumed in Bangladesh.

Food and nutrition security are essential for accomplishing sustainable development goals, and a growing population requires various food sources to address hunger and nutrition. Indigenous vegetables are nutritious, healthy, and adaptable to local conditions, making them a potential food and nutrition security resource. Thus, this study aimed to evaluate the nutritional richness of indigenous vegetables by comparing the nutritional content of commonly grown indigenous vegetables like Chenopodium album (Bathua), Coccinia grandis (Telakucha), Amaranthus viridis (Shaknotey), Moringa oleifera (Shojne), Alternanthera philoxeroides (Malancha), and Xanthium strumarium (Ghagra) to BARI Lalshak-1 (Amaranthus tricolor).

Suitability of early rice for the preparation of rice noodles by its starch properties analysis.

The research was conducted to explore the affiliation between the physicochemical properties of rice noodles and rice starch of early rice samples of varying amylose content. 3 various types of rice samples were analyzed to uncover how amylose content influences rice noodles' quality. Findings revealed that primarily sensory scores differ in palatability, while textural disparity lies in hardness and chewiness.

Maximizing the impact of megaprojects: Urgent implications of financial inclusion drive for effective anti-poverty measures.

Megaprojects are becoming more and more essential for poverty reduction and inclusive development. Regrettably, the CPEC mega project has yet to yield successful outcomes in Pakistan. The incorporation of financial inclusion (FI) has the potential to catalyze its outcomes.

Investigating the effect of , on using integrated computational approaches.

Unlabelled: , a notorious member of the ESKAPE pathogens, poses significant public health challenges due to its virulence and multidrug-resistant nature, particularly in methicillin-resistant (MRSA) strains. With the increasing threat of antibiotic resistance, there is an urgent need to develop novel antibiotic agents. This study therefore aims to explore the antibacterial potential of ,-dibenzoylhydrazine (DBH) as a scaffold against drug target enzymes, using integrated computational approaches.