Ethnopharmacological Perspective for Treatment of Epilepsy: An Updated Review.

Plants have been used as healing agents since humanity began. This review presents the plant profiles inhabiting the world regarding their traditional usage by various tribes/ethnic groups for the treatment of epilepsy. The bibliographic investigation was carried out by analyzing standard reference textbooks, Science Direct, Google Scholar, Scopus, Medline, Web of Science, and PubMed databases.

Dehydrogenative Coupling for Synthesis of Quinazolin-4(3H)-ones via Tandem Reaction using Ruthenium(II)-Phenyl-Azo-Naphthaldoxime: An Experimental and Theoretical Investigation.

The bidentate N, N, donor phenyl-azo-naphthaldoxime NpLH, 1 was used to synthesize the ruthenium(II) complex trans-[Ru(NpL)(CO)Cl(PPh)], 2. It has been characterized by SCXRD, electrochemical and spectral studies. Computational analysis indicates that the low-lying π*-LUMO of the complex has substantial azo-character of coordinated ligand.

Host defense peptides at the crossroad of endothelial cell physiology: Insight into mechanistic and pharmacological implications.

Antimicrobial peptides (AMPs), particularly host defense peptides (HDPs), have gained recognition for their role in host defense mechanisms, but they have also shown potential as a promising anticancer, antiviral, antiparasitic, antifungal and immunomodulatory agent. Research studies in recent years have shown HDPs play a crucial role in endothelial cell function and biology. The function of endothelial cells is impacted by HDPs' complex interplay between cytoprotective and cytotoxic actions as they are known to modulate barrier integrity, inflammatory response and angiogenesis.

Resilience Against Resistance: Exploring Cutting-edge Therapies for Methicillin-resistant Staphylococcus aureus (MRSA).

Methicillin-resistant Staphylococcus aureus [MRSA] stands as an enduring threat within healthcare landscapes, characterized by its ability to rapidly evolve and develop resistance to conventional antibiotics. This comprehensive review embarks on a journey through the historical landscape of MRSA, elucidating its initial emergence and subsequent evolution of resistance mechanisms over time. The narrative unfolds to underscore the profound impact of MRSA on patient outcomes and healthcare systems globally.

Identification of pivotal genes and pathways in Chorea-acanthocytosis using comprehensive bioinformatic analysis.

Chorea-acanthocytosis (ChAc), an autosomal recessive disorder, is associated with cognitive and behavioral abnormalities. Previous studies were focused around exploring the functional annotation of VPS13A gene in ChAc, whereas the genetic labyrinth underlying this disease and plausible drug targets were underexplored. In the present study, we have identified the pivotal genes and molecular pathways implicated in ChAc using comprehensive bioinformatics analysis.

A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues.

Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversible tissue electroporation is presented for injecting drug into the diseased cells. The model emphasizes the tissue boundary where the drug is injected as a point source.

Nanotechnology in Orthodontics: Unveiling Pain Mechanisms, Innovations, and Future Prospects of Nanomaterials in Drug Delivery.

Orthodontic pain is characterized by sensations of tingling, tooth discomfort, and intolerance. According to the oral health report, over forty percent of children and adolescents have undergone orthodontic treatment. The efficacy of orthodontic treatment involving braces can be compromised by the diverse levels of discomfort and suffering experienced by patients, leading to suboptimal treatment outcomes and reduced patient adherence.

Carbon sequestration and credit potential of gamhar (Gmelina arborea Roxb.) based agroforestry system for zero carbon emission of India.

The agroforestry system is the best option to achieve the net zero carbon emissions target for India. Keeping this view, carbon sequestration and credit potential of gamhar based agroforestry system has been assessed. The experiment was carried out in randomized block design in seven different treatments with five replications.

Phosphatidylcholine (PCL) fortified nano-phytopharmaceuticals for improvement of therapeutic efficacy.

Phytopharmaceuticals, derived from plants, are increasingly recognized for their potential therapeutic benefits. However, their effectiveness is often hindered by challenges such as poor bioavailability, stability, and targeted delivery. In this study, we aimed to address these limitations by developing PCL (phosphatidylcholine) fortified nano-phytopharmaceuticals to enhance therapeutic efficacy.

Perceptions and factors associated with COVID Appropriate Behavior (CAB) obedience among general public in India: A mixed methods research.

Background: The purpose of the study was to analyze the public perception toward COVID Appropriate Behavior (CAB) obedience and to identify the factors associated with declining CAB.

Materials And Methods: It is a mixed methods study conducted from November 2021 to September 2022 in Pune city, India. A set of 15-CAB guidelines published by the Ministry of Health and Family Welfare, Government of India (GoI), were used as a base document to design the instruments of qualitative and quantitative study.

Extremal topological indices of some nanostructures.

In this work, general formulas of degree-based and neighborhood degree sum-based topological indices for a 2D lattice of H-Naphtalenic nanotubes and pent-heptagonal nanosheets are determined. As an example, six neighborhood degree sum-based topological indices are computed using the obtained formula. Furthermore, the extremal cases of these nanostructures with a fixed number of blocks are characterized for a given degree-based or neighborhood degree sum-based topological index.

Electron transfer catalysis mediated by 3d complexes of redox non-innocent ligands possessing an azo function: a perspective.

It was first reported almost two decades ago that ligands with azo functions are capable of accepting electron(s) upon coordination to produce azo-anion radical complexes, thereby exhibiting redox non-innocence. Over the past two decades, there have been numerous reports of such complexes along with their structures and diverse characteristics. The ability of a coordinated azo function to accept one or more electron(s), thereby acting as an electron reservoir, is currently employed to carry out electron transfer catalysis since they can undergo redox transformation at mild potentials due to the presence of energetically accessible energy levels.

Advanced pulmonary drug delivery formulations for the treatment of cystic fibrosis.

Cystic fibrosis (CF), a fatal genetic condition, causes thick, sticky mucus. It also causes pancreatic dysfunction, bacterial infection, and increased salt loss. Currently available treatments can improve the patient's quality of life.

Modelling of reversible tissue electroporation and its thermal effects in drug delivery.

Electroporation is a very useful tool for drug delivery into various diseased tissues of the human body. This technique helps to improve the clinical treatment by transferring drugs into the targeted cells rapidly. In electroporation, drug particles enter easily into the intracellular compartment through the temporarily permeabilized cell membrane due to the applied electric field.

LGBM-ACp: an ensemble model for anticancer peptide prediction and in silico screening with potential drug targets.

Conventional cancer therapies are highly expensive and have serious complications. An alternative approach now emphasizes on the development of small, biologically active peptides without acute toxicity. Experimental screening to find curative anticancer peptides (ACP) often gives rise to multiple obstacles and is time dependent.

Medical Tourism in Tripura: Issues & Opportunities.

Medical tourism in India has an immense scope, primarily due to the unavailability or inaccessibility of medical treatment in border areas of native countries, such as Bangladesh and Myanmar. Also, the significantly low cost of complex surgery and highly skilled doctors are the most significant factors for driving tourism in India. Thus, there is a vast scope for entrepreneurship in this area.

The impact of COVID-19 pandemic on employees organizational commitment and job satisfaction in reference to gender differences.

In this study, an attempt has been made to examine the level of organizational commitment and job satisfaction among male and female school teachers working in private schools during the Covid-19 pandemic. For the present study, descriptive method is used. The sample of 181 private school teachers was drawn using a purposive sampling procedure.

Image analysis of PVC / TiO nanocomposites SEM micrographs.

The present paper deals with image analysis of Scanning Electron Microscope (SEM) micrographs of PVC / TiO nanocomposites prepared through solution casting technique at different wt% of TiO nanofillers dispersed within the PVC matrix. The qualitative and quantitative dispersion of TiO nanofillers is estimated through the proposed algorithm based on global threshold obtained from Otsu's method. The PVC-TiO- PVC molecular region map and TiO nanofillers dispersion maps are obtained by background elimination technique with predefined threshold value and a global threshold value, respectively.

Solvent-Induced Reversible Spin-Crossover in a 3D Hofmann-Type Coordination Polymer and Unusual Enhancement of the Lattice Cooperativity at the Desolvated State.

The new 3D Hofmann-type coordination polymer [Fe(dpyu){Pt(CN)}]·9HO [dpyu = 1,3-di(pyridin-4-yl)urea] exhibits reversible interchange between two- and one-step spin-crossover behavior, associated with desorption/resorption of lattice water molecules. Solvent water removal also induces an increase of the spin-transition temperature, indicating strong lattice cooperativity, observed for the first time in a 3D Hofmann-type coordination polymer.

A review of modern technologies for tackling COVID-19 pandemic.

Objective: Science and technology sector constituting of data science, machine learning and artificial intelligence are contributing towards COVID-19. The aim of the present study is to discuss the various aspects of modern technology used to fight against COVID-19 crisis at different scales, including medical image processing, disease tracking, prediction outcomes, computational biology and medicines.

Methods: A progressive search of the database related to modern technology towards COVID-19 is made.

Remarkable Energy Barrier for Magnetization Reversal in 3D and 2D Dysprosium-Chloranilate-Based Coordination Polymers.

Herein, two coordination polymers (CPs) [{Dy(Cl An) (CH OH)}⋅4.5 H O] (1) and [Dy(Cl An) (DMF) ] (2), in which Cl An is chloranilate (2,5-dihydroxy-1,4-benzoquinone dianion), exhibiting field-induced single-molecule magnet behavior with moderate barrier of magnetization reversal are reported. Detailed structural and topological analysis disclosed that 1 has a 3D network, whereas 2 has a 2D layered-type structure.

Microbial based assay for specific detection of β-lactam group of antibiotics in milk.

The spore forming Bacillus cereus (66) was screened for the induction of β-lactamase in presence of an inducer using iodometric assay. A significant induction in marker enzyme was observed in B. cereus 66 at maximum residual limit (MRL) of penicillin, ampicillin, cloxacillin, amoxicillin, cefalexin, and cephazolin belonging to β-lactam group of antibiotics.