Divergent Contribution of Cytoplasmic Actins to Nuclear Structure of Lung Cancer Cells.

A growing body of evidence suggests that actin plays a role in nuclear architecture, genome organisation, and regulation. Our study of human lung adenocarcinoma cells demonstrates that the equilibrium between actin isoforms affects the composition of the nuclear lamina, which in turn influences nuclear stiffness and cellular behaviour. The downregulation of β-actin resulted in an increase in nuclear area, accompanied by a decrease in A-type lamins and an enhancement in lamin B2.

[The perception of problematic of digital future of national health care by students and graduates of medical university].

In the nearest future, global health care is to be changed dramatically because of digital transformation of medicine that is supported by numerous innovative technologies. The digitization of Russian health care nowadays is priority direction of its development. It requires from medical workers to have special knowledge and readiness to apply achievements of digital medicine as effectively as possible.

[The dynamics of provision of population of the Russian Federation with otorhinolaryngologists in 2018-2023].

The most acute problem of state health care system is shortage of medical personnel, both physicians and paramedics. The purpose of the study is to assess dynamics of personnel support with otolaryngologists in medical organizations of the Russian Federation for 2018-2023. The retrospective analytical descriptive study was carried out using continuous method based on studying dynamics of personnel support with otolaryngologists in the Russian Federation in general, Federal Okrugs and particular Subjects of the Russian Federation for 2018-2023.

[The dynamics of morbidity of adult population of The Russian Federation by diseases of ear and mastoid in 2018-2022].

The purpose of the study is to assess dynamics of level of common and primary morbidity in class of diseases of ear and mastoid in adult population of the Russian Federation in 2018-2022. The analysis of morbidity indicators was carried out on the basis of data from statistical collections of Minzdrav of Russia and the Federal State Budget Institution "The Central Research Institute for Health Organization and Informatics of Minzdrav of Russia". It is established that in the Russian Federation, level of common and primary morbidity in class of diseases of ear and mastoid in adult population in 2018-2022 was decreasing and reached its lowest values in 2022 (2875.

[The programs of additional legal education as necessary element of system of training of students of medical university].

The actual trends in training of health care professionals set before medical university task of actualization and diversification of training programs targeted to formation both professional and universal competencies to contribute to variable combination of different skills and habits in implementation of medical activities. The increasing needs of labor market in specialists capable to meet actual realities and associated with transformational transition from narrow specialization to different specific skills, inevitably results into increasing of importance for additional education programs as an element of continuing The following key features of various proposals for additional professional education programs were singled out. The major task of forming proposal of additional programs is seen by university through prism of possible increasing of income.

[The demographic, social and professional factors affecting choice of employment place and labor motivation of general practitioners and districts therapists].

The article considers social, demographic and professional factors determining choice by general practitioners and district therapists of place of employment and their professional motivation. The special questionnaire was developed to be applied in sociological survey. The sampling included general practitioners and district therapists of outpatient medical organizations of the Health Department and the private health care sector of Moscow.

[The population satisfaction with medical care quality according National monitoring of public health in the Russian Federation].

The article presents updated information concerning satisfaction of patients with quality of medical care in public and private health care institutions in Russia. The purpose of the study is to explore satisfaction with medical services in different groups of Russian population using representative sampling and considering various aspects of medical care quality. The statistical analysis on the basis of data of telephone survey "The National Monitoring of Public Health" (2022) was applied.

[The Russian priority in development of general intravenous anesthesia (Report II)].

The article considers evaluation of works of colleagues and contemporaries of N. P. Kravkov, the creator of "Russian narcosis" with hedonal.

[The impact of public organizations on development of professional qualification of medical workers].

The professional development of personnel is one of highest priority task of development of both medicine as science and health system as mechanism protecting health of citizens. The public organizations are professional communities of medical specialists specializing in particular sectors of medicine that actively participate in implementation of educational measures and other initiatives targeted to support opportunities for professional growth and improving competence level of participants of these communities. The article considers examples of such initiatives as exemplified by foreign and Russian public organizations of pulmonologists and dentists.

Imbalance between Actin Isoforms Contributes to Tumour Progression in Taxol-Resistant Triple-Negative Breast Cancer Cells.

The widespread occurrence of breast cancer and its propensity to develop drug resistance highlight the need for a comprehensive understanding of the molecular mechanisms involved. This study investigates the intricate pathways associated with secondary resistance to taxol in triple-negative breast cancer (TNBC) cells, with a particular focus on the changes observed in the cytoplasmic actin isoforms. By studying a taxol-resistant TNBC cell line, we revealed a shift between actin isoforms towards γ-actin predominance, accompanied by increased motility and invasive properties.

[The Russian priority of development of intravenous anesthesia (Report I).].

The article analyses research activities of the discoverers of "Russian narcosis" from the Military Medical Academy of St. Petersburg: the head of the Department of Pharmacology N. P.

[The social, demographic and professional characteristics of general practitioners and district therapists of state and private sectors of health care].

The article presents comparative analysis of demographic, social and professional characteristics of general practitioners and district therapists in state and private medical organizations. Sociological, statistical and analytical research methods were applied. The study was carried out on the basis of polyclinics of both Moscow Health Department and Moscow private health care sector.

Actin-Dependent Mechanism of Tumor Progression Induced by a Dysfunction of p53 Tumor Suppressor.

Cancer cell aggressiveness, marked by actin cytoskeleton reconfiguration critical for metastasis, may result from an imbalanced ratio favoring γ-actin. Dysfunctional p53 emerges as a key regulator of invasiveness and migration in various cancer cells, both in vitro and in vivo. P53 inactivation (via mutants R175H, R248W, R273H, or TP53 repression) significantly enhanced the migration, invasion, and proliferation of human lung adenocarcinoma A549 cells in vitro and in vivo, facilitating intrapulmonary xenograft metastasis in athymic mice.

[The mobile applications developed for self-control arterial pressure: systematic review and content-analysis].

The high prevalence of arterial hypertension and necessity for permanent monitoring of blood pressure requires implementation of new methods of interaction between patient and physician in order to optimize medical care. The purpose of the study was to describe and to evaluate functional possibilities of Russian-speaking mobile applications utilized in collecting blood pressure readings to monitor efficiency of arterial hypertension treatment. The study was carried out in June 2023 in three mobile application stores: Apple Store, Google Play and RuStore.

[The effect of characteristics of patient on satisfaction with medical care rendered by general practitioner and district therapist].

The patient satisfaction is one of the key criteria of quality of medical care and indicator of patient-oriented approach and factor determining competitiveness of medical organization. The purpose of the study - the comparative analysis of patient satisfaction with primary health care provided by general practitioner and district physician, taking into account their gender, age characteristics, frequency and goals of visiting polyclinic. Sociological study was carried out on the basis of out-patient medical organizations in Moscow, Kemerovo and Belgorod.

[On the history of formation and characteristics of development of the chair of social hygiene, the first one in Russia].

The purpose of the study is to analyze changes occurred, against the background of social challenges, in functioning of the Chair of Social Hygiene since its establishment in 1922 at the Faculty of Medicine of the I Moscow State University to the present time at the N. A. Semashko Chair of Public Health and Health Care at the Sechenov University.

[The rise of attractiveness of specialty "General Practice" for graduates of medical universities].

The choice of specialty by graduate of medical university can be promoted by particular social, demographic and personal characteristics. Purpose of the study is to investigate demographic, social and personal characteristics of students in residency on specialty "General Medical Practice" in the Russian Federation. The sociological, statistical and analytical methods are applied.

[The influence of gender, age and length of service on educational preferences of general practitioners in Russia].

In conditions of active development of medical and pharmaceutical sciences and dynamically changing work environment the education of physician is to be both continuous and personalized. Purpose of the study. To investigate effect of gender, age and work experience on educational needs and on preferences of forms and methods of training in the system of continuing medical education of Russian general practitioners.

[The analysis of problems of supporting long-term nursing of individuals who lost their ability to self-care in Russia].

The article considers the issues of social assistance of long-term care of individuals who lost ability to self-care. The comparative analysis of established practices of social assistance of long-term care, of legal and financial support of family members implementing such a care in Russia and European countries is presented. The study was carried out using comparative jurisprudence methodology.

[The certain issues of supporting non-barrierness of objects and services for not mobile citizen].

The article presents analysis of establishing conditions to adapt the environment and to remove barriers for not mobile citizen (the disabled with disorders of musculoskeletal system). In the process of analysis of possibilities to organize non-barrier environment for not mobile citizen the national and foreign normative legal acts, international conventions, materials of national and foreign experts, Internet sources were used. The analysis of current international regulation of non-barrier urban environment for not mobile citizen demonstrates gradual transition from medical concept of disability to social one.

[The optimization of routing of patients with atherosclerosis of brachiocephalic arteries as exemplified by preventive examination in "Healthy Moscow" pavilions].

The article presents analysis of the program of preventive examinations of Moscow residents in the "Healthy Moscow" pavilions and the routing of patients with established atherosclerosis of brachiocephalic arteries. In 2022, within the framework of preventive examinations (check-ups) of Moscow residents in the "Healthy Moscow" pavilions, the pilot project of organization of surgical treatment of patients with established pathology of pre-cerebral arteries. The project included additional ultrasound examination of brachiocephalic arteries of males aged 45-72 years and females aged 54-72 years.

[The comparative analysis of dynamics of indicators of morbidity of adolescents in the regions of the Northern-Caucasus Federal Okrug].

The purpose of the study is to establish main trends in morbidity of adolescents (15-17 years old) in the regions of the Northern-Caucasus Federal Okrug in 2011-2020. The study is based on data of statistical reports on primary and general morbidity of population aged 15-17 years for 2011-2020. The results.

[The prevalence of emotional burning-out syndrome of medical workers in the Russian Federation: Systematic review and meta-analysis].

The burnout is a syndrome that occurs as a result of chronic stress at workplace that is extremely difficult to successfully manage. Many epidemiological studies concerning professional burnout of health care workers were already implemented in Russia. The purpose of the study was to assess overall burnout prevalence rate among health care workers practicing in Russia.