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MicroRNA expression profiling outperforms mRNA expression profiling in formalin-fixed paraffin-embedded tissues.
Int J Clin Exp Pathol
March 2009
Department of Pathology and Laboratory Medicine 6 Founders Pavilion, The Hospital for the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA.
microRNAs (miRNAs) are approximately 22nt RNAs that regulate target gene expression. Altered expression of miRNAs has been demonstrated in many different human cancers. Many studies using microarray technologies to characterize miRNA expression profiles have relied on fresh tissue to determine the miRNA signatures.
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