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The C terminus of sprouty is important for modulation of cellular migration and proliferation.

J Biol Chem

June 2001

Department of Pharmacology and the Vascular Biology Center of Excellence, The Health Science Center University of Tennessee, Memphis, Tennessee 38163, USA.

The Drosophila Sprouty (SPRY) protein has been shown to inhibit the actions of epidermal growth factor and fibroblast growth factor. However, the role of mammalian SPRY proteins has not been clearly elucidated. We postulated that human Sprouty2 (hSPRY2) is an inhibitor of cellular migration and proliferation.

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