401 results match your criteria: "The Harvard Medical School[Affiliation]"

Total Shoulder Arthroplasty in Octogenarians and Nonagenarians: A Database Study of 33,089 Patients.

J Am Acad Orthop Surg

November 2024

From the Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA (Zhang), the Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA (Dr. Elhassan), and the Harvard Medical School, Boston, MA (Dr. Zhang and Dr. Elhassan).

Article Synopsis
  • The study investigates the risk of 30-day complications after total shoulder arthroplasty (TSA) in older patients, specifically those aged 80 and over, using a national database from 2011 to 2020.
  • Among the 33,089 patients analyzed, octogenarians (80-89 years) experienced 8% complication rates and nonagenarians (90 years and above) had 16%, compared to just 4% in patients under 80.
  • The findings highlight the increased odds of complications and readmission for elderly patients, which is essential for preoperative counseling and decision-making regarding TSA.
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Interferon Interrupted: Are P2Y Antagonists the Next Step to Target Platelets in Autoimmunity?

JACC Basic Transl Sci

September 2024

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; and the Harvard Medical School, Boston, Massachusetts, USA.

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Athletic Identity Associations in Young Sports Medicine Patients.

J Am Acad Orthop Surg Glob Res Rev

September 2024

From the Division of Sports Medicine, Department of Orthopedic Surgery, Boston Children's Hospital, Boston, MA (Mr. Christino, Mr. Coene, Dr. Ackerman, Dr. Stracciolini, and Dr. Kramer); the Harvard Medical School, Boston, MA (Dr. Christino, Dr. Ackerman, Dr. Stracciolini, and Dr. Kramer); the Biostatistics and Research Design Center, ICCTR, Boston Children's Hospital, Boston, MA (Ms. Williams); and the Children's Hospital of Philadelphia, Philadelphia, PA (Dr. Daley).

Introduction: Few studies have assessed athletic identity levels in young patients. This study examined athletic identity in adolescents and explored associations between athletic identity, patterns of sport participation, and coping skills.

Methods: Patients aged 12 to 18 years who received sports medicine care completed a one-time, voluntary, anonymous survey.

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Machine-Learning-Based Multi-Modal Force Estimation for Steerable Ablation Catheters.

IEEE Trans Med Robot Bionics

August 2024

Department of Electrical and Computer Engineering, Western University, London, ON, Canada, and Canadian Surgical Technologies and Advanced Robotics (CSTAR), University Hospital, LHSC, London, ON, Canada.

Catheter-based cardiac ablation is a minimally invasive procedure for treating atrial fibrillation (AF). Electrophysiologists perform the procedure under image guidance during which the contact force between the heart tissue and the catheter tip determines the quality of lesions created. This paper describes a novel multi-modal contact force estimator based on Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs).

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A 79-Year-Old Woman With Worsening Headaches and Pachymeningeal Enhancement: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurol Neuroimmunol Neuroinflamm

November 2024

From the Harvard Medical School (M.S.S., T.C.); Department of Neurology (M.S.S., T.C.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (D.E.H., J.C.M.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology and Program in Immunology (S.S.Z.), University of California at San Francisco; Department of Neurology (M.D.G.), Virginia Commonwealth University, Richmond; and Department of Neurology (C.R.), Columbia University, New York.

A 79-year-old woman presented with subacutely worsening headaches and right arm weakness. MRI showed diffuse pachymeningeal enhancement. Serologic workup revealed elevated erythrocyte sedimentation rate and C-reactive protein.

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Background: Little is known about practice patterns and payments for immediate lymphatic reconstruction (ILR). This study aims to evaluate trends in ILR delivery and billing practices.

Methods: We queried the Massachusetts All-Payer Claims Database between 2016 and 2020 for patients who underwent lumpectomy or mastectomy with axillary lymph node dissection for oncologic indications.

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Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes.

Neurology

June 2024

From the Harvard Medical School (V.M.B., W.T.K.), Boston, MA; Equity Research and Innovation Center (C.R.O.), Yale School of Medicine, New Haven, CT; Center for Genomic Medicine (Z.A., N.K., W.T.K.) and Department of Neurology (Z.A., N.K., A.-L.G.G., W.T.K.), Massachusetts General Hospital, Boston; Division of Neurology (N.K.), Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Departments of Epidemiology (A.C.J., C.A.C., A.P., M.R.I.) and Biostatistics (A.B.), School of Public Health, and Department of Psychology (M.C.), University of Alabama at Birmingham.

Background And Objectives: Ultra-processed foods (UPFs) are linked to cardiometabolic diseases and neurologic outcomes, such as cognitive decline and stroke. However, it is unclear whether food processing confers neurologic risk independent of dietary pattern information. We aimed to (1) investigate associations between UPFs and incident cognitive impairment and stroke and (2) compare these associations with other commonly recommended dietary patterns in the REasons for Geographic and Racial Differences in Stroke study.

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Article Synopsis
  • The study highlights the importance of imaging stewardship in emergency departments, focusing on a new survey spine MR imaging protocol aimed at suspected cord compression (CC) while minimizing unnecessary imaging.* -
  • Over 2000 patients were analyzed from 2018 to 2022, with a 14.2% positivity rate for CC among those examined; the protocol was significantly faster, averaging about 5 minutes and 50 seconds.* -
  • Key symptoms related to CC included trauma and various neurological issues, with most patients requiring surgical or medical management based on their findings.*
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Association of Pharmacologic Treatment of Depression/Anxiety With Initial Patient-Reported Outcome Measures in Patients With Hip and Knee Osteoarthritis.

J Am Acad Orthop Surg

June 2024

From the Harvard Medical School, Boston, MA (Farid, Liimakka, and Parker), the Department of Orthopaedic Surgery, Division of Adult Reconstruction and Total Joint Arthroplasty, Brigham and Women's Hospital, Boston, MA (Liimakka, Chen, and Lange), the Department of Orthopaedic Surgery, Division of Foot and Ankle Surgery, Brigham and Women's Hospital, Boston, MA (Parker and Smith), and the Department of Orthopaedic Surgery, Hip & Knee Replacement Service, Massachusetts General Hospital, Boston, MA (Melnic).

Introduction: Depression and anxiety are common comorbidities that may exacerbate osteoarthritis (OA)-related pain. We aim to evaluate the effect of pharmacologic treatment of depression/anxiety on hip and knee patient-reported outcome measures (PROMs).

Methods: A multi-institutional PROMs database was queried for patients with depression or anxiety and hip or knee OA who completed a PROMs questionnaire at an initial orthopaedic visit between January 2015 and March 2023.

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The Relationship Between Preoperative International Normalized Ratio and Postoperative Major Bleeding in Total Shoulder Arthroplasty.

J Am Acad Orthop Surg Glob Res Rev

April 2024

From the Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA (Dr. Zhang, Dr. Dyer, and Dr. Earp), and the Harvard Medical School, Boston, MA (Dr. Zhang, Dr. Dyer, and Dr. Earp).

Introduction: This study aimed to assess the relationship between preoperative international normalized ratio (INR) levels and major postoperative bleeding events after total shoulder arthroplasty (TSA).

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was queried for TSA from 2011 to 2020. A final cohort of 2405 patients with INR within 2 days of surgery were included.

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The aim of this study was to examine worsening of OCD symptoms after childbirth in individuals seeking assessment or treatment of OCD. The postpartum period may make parents biologically and psychologically vulnerable to OCD symptoms. Participants included 222 parents with OCD who completed surveys through a self-help website.

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Article Synopsis
  • - This study examined how to best monitor branch-duct type intraductal papillary mucinous neoplasms (BD-IPMN) that haven't been surgically removed, focusing on surveillance frequency and when it can be safely stopped.
  • - It systematically reviewed available literature and found that cysts under 2 cm with no concerning features generally show low growth rates and minimal risk of becoming cancerous, allowing for a more relaxed approach to monitoring.
  • - The research suggests that patients with stable small cysts may not need as frequent surveillance and could potentially stop monitoring after 5 years, leading to better resource management in healthcare.
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Reply to C M Sciarrillo et al.

J Nutr

March 2024

The Harvard Medical School, Boston, MA, United States; The New Balance Foundation Obesity Prevention Center, Boston Children's Hospital, Boston MA, United States; The Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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Background: The literature is meager regarding the natural history and outcomes of infantile hemangiomas (IHs) in the breast. Treatment in childhood may be considered due to psychosocial and physical concerns with breast development. Early surgical intervention may cause iatrogenic breast asymmetry and possibly impair lactation later in life.

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Navigating and Communicating about Serious Illness and End of Life.

N Engl J Med

January 2024

From the Department of Medicine, Division of Palliative Care and Geriatric Medicine (V.A.J.), and the Center for Aging and Serious Illness Research (V.A.J., L.E.) and Cancer Outcomes Research and Education Program (V.A.J.), the Mongan Institute, Massachusetts General Hospital, and the Harvard Medical School Center for Palliative Care (V.A.J.) - both in Boston; and the Department of Supportive Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern Medical Group, Feinberg School of Medicine, Chicago (L.E.).

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Rationale And Objectives: To assess differences in radiomics derived from semi-automatic segmentation of liver metastases for stable disease (SD), partial response (PR), and progressive disease (PD) based on RECIST1.1 and to assess if radiomics alone at baseline can predict response.

Materials And Methods: Our IRB-approved study included 203 women (mean age 54 ± 11 years) with metastatic liver disease from breast cancer.

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The Role of Epigenetics in Accelerated Aging: A Reconsideration of Later-Life Visual Loss After Early Optic Neuropathy.

J Neuroophthalmol

March 2024

Department of Ophthalmology and the Neuro-Ophthalmology Service (JFR), Massachusetts Eye and Ear and the Harvard Medical School, Boston, Massachusetts; Avedisian and Chobanian School of Medicine (MPS), Boston University, Boston, Massachusetts; Department of Ophthalmology (MPS, DK, BRK), Harvard Medical School, Schepens Eye Research Institute of Mass Eye & Ear, Boston, Massachusetts; Department of Biology (YRL), Whitehead Institute for Biomedical Sciences, MIT, Cambridge, Massachusetts; and Paul F. Glenn Center for Biology of Aging Research (DAS), Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.

Background: In 2005, we reported 3 patients with bilateral optic nerve damage early in life. These patients had stable vision for decades but then experienced significant bilateral vision loss with no obvious cause. Our hypothesis, novel at that time, was that the late decline of vision was due to age-related attrition of retinal ganglion cells superimposed on a reduced neuronal population due to the earlier injury.

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Outcomes of Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture Versus Rotator Cuff Arthropathy.

J Am Acad Orthop Surg Glob Res Rev

October 2023

From the Harvard Combined Orthopaedic Residency Program, Boston, MA (Dr. Maier II); the Harvard Medical School, Boston, MA (Ms. Prabhat); the Brigham and Women's Hospital, Boston, MA (Dr. Collins); the Division of Orthopaedic Trauma, Bispebjerghospitalet, University of Copenhagen, Copenhagen, Denmark (Dr. von Keudell); and the Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA (Dr. von Keudell, Dr. Earp, and Dr. Zhang).

Introduction: Reverse total shoulder arthroplasty (RSA) is used to treat a variety of shoulder-related pathologies. This study compared medium-term clinical outcomes of less than 10-year follow-up in patients treated with RSA for proximal humerus fracture (PHF) versus rotator cuff arthropathy (RCA).

Methods: This retrospective review was conducted at two tertiary care centers, in which self-reported clinical outcomes were assessed using four validated instruments, that is, American Shoulder and Elbow Society (ASES) score, Shoulder Pain and Disability Index (SPADI), visual analog scale (VAS), and shoulder subjective value (SSV).

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