6 results match your criteria: "The H.C. Ørsted Institute[Affiliation]"
Prevalence and Associated Factors of -Positive- in Different Reservoirs around Farms in Vietnam.
Antibiotics (Basel)
May 2023
Hanoi Medical University, Hanoi 100000, Vietnam.
Article Synopsis
- Linezolid is an important last-resort antibiotic for treating serious infections caused by Gram-positive bacteria, but resistance to it is a growing concern, especially due to the role of veterinary antibiotic use.
- A study in Vietnam found that the highest prevalence of linezolid-resistant Enterococcus pathogens was in flies (46.8%), with significant rates also found in chickens and dogs, indicating a troubling trend in these reservoirs.
- Genetic analysis showed connections between resistant strains from different sources, highlighting the potential for flies to transmit antibiotic-resistant bacteria among animals and humans, even though linezolid isn’t used in livestock.
The identification of novel immunogenic antigens as potential Shigella vaccine components.
Genome Med
January 2021
Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Level 5, Jeffery Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0AW, UK.
Background: Shigella is a major diarrheal pathogen for which there is presently no vaccine. Whole genome sequencing provides the ability to predict and derive novel antigens for use as vaccines. Here, we aimed to identify novel immunogenic Shigella antigens that could serve as Shigella vaccine candidates, either alone, or when conjugated to Shigella O-antigen.
View Article and Find Full Text PDFPathogenic Possess Elevated Growth Rates under Exposure to Sub-Inhibitory Concentrations of Azithromycin.
Antibiotics (Basel)
October 2020
Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge CB2 0AW, UK.
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of the ten major threats to global health. Advances in technology, including whole-genome sequencing, have provided new insights into the origin and mechanisms of AMR. However, our understanding of the short-term impact of antimicrobial pressure and resistance on the physiology of bacterial populations is limited.
View Article and Find Full Text PDFGenomic Serotyping, Clinical Manifestations, and Antimicrobial Resistance of Nontyphoidal Gastroenteritis in Hospitalized Children in Ho Chi Minh City, Vietnam.
J Clin Microbiol
November 2020
Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, United Kingdom
Article Synopsis
- * The most common serovar identified was Typhimurium, making up 41.8% of the NTS isolates, and over half of these strains were found to be multidrug resistant (MDR), raising concerns about treatment efficacy.
- * Genome sequencing proved useful in understanding serovar diversity and antimicrobial resistance (AMR), suggesting a need to reconsider current treatment guidelines and strengthening ongoing surveillance of NTS.
Assessing gut microbiota perturbations during the early phase of infectious diarrhea in Vietnamese children.
Gut Microbes
January 2018
a Department of Enteric Infections, The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme , Oxford University Clinical Research Unit, Ho Chi Minh City , Vietnam.
Diarrheal diseases remain the second most common cause of mortality in young children in developing countries. Efforts have been made to explore the impact of diarrhea on bacterial communities in the human gut, but a thorough understanding has been impeded by inadequate resolution in bacterial identification and the examination of only few etiological agents. Here, by profiling an extended region of the 16S rRNA gene in the fecal microbiome, we aimed to elucidate the nature of gut microbiome perturbations during the early phase of infectious diarrhea caused by various etiological agents in Vietnamese children.
View Article and Find Full Text PDFThe genomic signatures of Shigella evolution, adaptation and geographical spread.
Nat Rev Microbiol
April 2016
The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 764 Vo Van Kiet, Quan 5, Ho Chi Minh City, Vietnam.
Shigella spp. are some of the key pathogens responsible for the global burden of diarrhoeal disease. These facultative intracellular bacteria belong to the family Enterobacteriaceae, together with other intestinal pathogens, such as Escherichia coli and Salmonella spp.
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