Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report.

Post-transplantation lymphoproliferative disease (PTLD) is a serious complication following hematopoietic stem cell transplantation (HSCT). The majority of the cases develop during the first year after the transplantation and are associated with reactivation of the Epstein-Barr virus (EBV); the EBV-induced lymphoproliferation usually includes donor-derived B cells. We herein describe the case of a 28-year-old female patient who developed EBV-negative PTLD, namely diffuse large B-cell lymphoma (DLBCL), 6 months after receiving a haploidentical HSCT from her father.

Serum microRNA181a: Correlates with the intracellular cytokine levels and a potential biomarker for acute graft-versus-host disease.

The aim of this study was to investigate the clinical relevance of lymphocyte-related serum miRNAs to the pathogenesis of acute graft-versus-host disease (aGVHD) and evaluate the predictive and prognosis value of miRNAs. Consecutive patients who received allogeneic peripheral blood stem cell transplantation (allo-PBSCT) in General Hospital of Jinan Military District were enrolled. aGVHD patients were diagnosed and graded clinically, and divided into the training set and the testing set.

Autologous stem cell transplantation for a monoclonal gammopathy of undetermined significance mimicking amyotrophic lateral sclerosis: A case report.

It is rare for patients with monoclonal gammopathy of undetermined significance (MGUS) to present with clinical features of fatal motor neuron disease, for example amyotrophic lateral sclerosis (ALS). There is no standard and effective therapy for either MGUS or ALS. In addition, stem cell transplantation appears to be ineffective for the treatment of this disease.

Increased immunosuppressive treatment combined with unrelated umbilical cord blood infusion in children with severe aplastic anemia.

A combination treatment of unrelated umbilical cord blood (UCB) and increased immunosuppressive treatment (IST) were investigated to reveal the potentially curative therapy for the severe aplastic anemia (SAA). A total of 36 children (2-17 ages) with SAA who received UCB infusion after an IST were analyzed. The treatment consisted of 100mg/kg cyclophosphamide, 12.

Role of biomarkers in management of complications after cardiac surgery.

The use of cardiopulmonary bypass distinguishes cardiac surgery from other types of surgery. It introduces some serious postoperative complications, such as acute organ dysfunction of the brain, heart, kidney, lungs and infection, which cause significant morbidity and mortality. Prevention and control of these complications are critical in the evolution of cardiac surgery and in the successful outcomes of most operations.

Serum microRNA155 is increased in patients with acute graft-versus-host disease.

To explore the clinical relevance of three lymphocyte-related serum microRNAs (miR-155, miR-214, and miR-326) to the pathogenesis of graft-versus-host disease (GVHD), 64 subjects who received allogeneic peripheral blood stem cell transplantation (allo-PBSCT) were recruited in this study, of whom 19 subjects did not develop GVHD, 25 subjects were diagnosed with acute GVHD (aGVHD), and 20 subjects were diagnosed with chronic GVHD (cGVHD). Serum miRNAs were determined by real-time RT-PCR. Expression level of miRNAs and the expression signatures of miRNAs as a panel were analyzed among the three groups.

Transcatheter closure of postoperative residual ventricular septal defects using Amplatzer-type perimembranous VSD occluders.

Objectives: The reoperations of postoperative residual ventricular septal defects (VSDs) are associated with higher risks. Our aim is to assess the efficacy and safety of transcatheter closure of postoperative residual VSDs using perimembranous VSD occluders.

Methods: Twenty-one patients with residual VSDs underwent transcatheter closure in our center from January 2005 to January 2012.