4 results match your criteria: "The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical University[Affiliation]"
FGR-associated placental insufficiency and capillary angiogenesis involves disruptions in human placental miRNAs and mRNAs.
Heliyon
March 2024
Department of Obstetrics and Gynecology, Hebei Medical University, Shijiazhuang, Hebei, PR China.
Article Synopsis
- - Fetal growth restriction (FGR) is a serious pregnancy complication linked to negative outcomes like preterm birth and stillbirth, often caused by issues with placental development and nutrient supply, which can be affected by the fetus's sex.
- - The study examined changes in gene expression and miRNA associated with placental dysfunction in FGR pregnancies using tissue samples from both FGR and control pregnancies, discovering that specific genes related to angiogenesis and other factors were altered.
- - Findings indicated that placental issues in FGR pregnancies may differ based on the sex of the newborn, with notable variations in gene expression and microvessel markers, suggesting that these changes might influence how placental impairment occurs.
hsa_circ_0005991 promotes epithelial-mesenchymal transition by regulating miR-30b-3p/Cdc42EP1 axis in ovary endometriosis.
Genomics
November 2023
Department of Obstetrics and Gynecology, Hebei Medical University, Shijiazhuang, Hebei 050000, China; Reproductive Medicine Center, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical University, Shijiazhuang, Hebei 050000, China. Electronic address:
Endometriosis is a common gynecological disease with an enigmatic pathogenesis. This work explored the function of hsa_circ_0005991 in ovarian endometriosis. High-throughput RNA-Seq was conducted in five matched ectopic (EC) and eutopic (EU) samples.
View Article and Find Full Text PDFCase report: Analysis of novel compound heterozygous variants in a Chinese patient with neuronal ceroid lipofuscinosis type 2.
Front Genet
August 2022
Key Laboratory of Maternal and Fetal Medicine of Hebei Province, Institute of Reproductive Medicine of Shijiazhuang, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical University, Shijiazhuang, China.
Neuronal ceroid lipofuscinosis type 2 (CLN2) is an autosomal recessive neurodegenerative disease caused by variants in the gene that lead to the deficiency of the lysosomal enzyme tripeptidyl peptidase I (TPP1) activity. Herein, we report a rare case of CLN2 caused by two novel variants of . The patient presented with seizures at onset, followed by progressive cognitive impairment, motor decline, and vision loss.
View Article and Find Full Text PDFmiR‑519d‑3p released by human blastocysts negatively regulates endometrial epithelial cell adhesion by targeting HIF1α.
Int J Mol Med
October 2022
Department of Obstetrics and Gynecology, Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
Successful embryo implantation requires a competent embryo, a receptive endometrium and synchronized communication between them. The selection of embryos with the highest implantation potential remains a challenge in the field of assisted reproductive technology. Moreover, little is known about the precise molecular mechanisms underlying embryo‑endometrium crosstalk.
View Article and Find Full Text PDF