5 results match your criteria: "The Fourth Hospital attached to Nanchang University[Affiliation]"
High-Throughput Metabolomics Method for Discovering Metabolic Biomarkers and Pathways to Reveal Effects and Molecular Mechanism of Ethanol Extract From Against Osteoporosis.
Front Pharmacol
August 2020
The First Affiliated Hospital of Nanchang University, Orthopaedics, Nanchang University, Nanchang, China.
Article Synopsis
- Metabolomics is used to investigate how herbal medicine, specifically Epimedium, can help treat osteoporosis (OP), but its exact mechanisms are not fully understood.
- A study analyzed the effects of ethanol extract from Epimedium on OP in rats, identifying 46 potential biomarkers, with 16 showing significant changes after treatment.
- Key pathways related to the efficacy of Epimedium included arachidonic acid and glycerophospholipid metabolism, highlighting how metabolomics can shed light on disease mechanisms and the effects of natural remedies.
MiR-151a-3p Promotes Postmenopausal Osteoporosis by Targeting SOCS5 and Activating JAK2/STAT3 Signaling.
Rejuvenation Res
August 2020
Department of Orthopaedics, The Fourth Hospital Attached to Nanchang University, Nanchang, China.
Postmenopausal osteoporosis, the most common type of primary osteoporosis, poses a significant threat to women's health worldwide. However, detailed molecular mechanism and therapeutic strategy for postmenopausal osteoporosis remain insufficient. Increasing evidence suggests that microRNAs contributed to the pathogenesis of osteoporosis and could be considered as potential therapeutic targets.
View Article and Find Full Text PDFMicroRNA-148a-3p promotes survival and migration of endothelial cells isolated from Apoe deficient mice through restricting circular RNA 0003575.
Gene
August 2019
Department of Cardiology, General Hospital of Heilongjiang Agricultural Reclamation Bureau, Ha'erbin, China. Electronic address:
The incidence of atherosclerosis is greatly increased, which becomes the leading cause for the death and disability worldwide. Endothelial cells dysfunction plays a substantial role in the pathogenesis of atherosclerosis. MicroRNA-148a-3p (miR-148a-3p) and circular RNA 0003575 (circ_0003575) modulated lipid metabolism and proliferative function of endothelial cells, respectively.
View Article and Find Full Text PDFZ-Guggulsterone attenuates glucocorticoid-induced osteoporosis through activation of Nrf2/HO-1 signaling.
Life Sci
May 2019
Department of Orthopaedics, The Fourth Hospital attached to Nanchang University, Nanchang, 330003, China. Electronic address:
Aims: The present study aims to investigate the protective effect and underlying mechanism of Z-Guggulsterone (Z-GS), an active component from myrrh, on glucocorticoid-induced osteoporosis (GIO).
Main Methods: GIO rats were used to simulate osteoporosis in vivo while MC3T3-E1 cells were induced to osteoblast differentiation and treated with dexamethasone to simulate osteoporosis in vitro. The rats and cells were treated with Z-GS according to the protocol.
High-throughput metabolomics investigates anti-osteoporosis activity of oleanolic acid via regulating metabolic networks using ultra-performance liquid chromatography coupled with mass spectrometry.
Phytomedicine
December 2018
Department of orthopaedics, The Fourth Hospital attached to Nanchang University, No. 133, Guangchang South Road, Xihu District, Nanchang, Jiangxi 330003, China. Electronic address:
Article Synopsis
- Osteoporosis poses significant socio-economic challenges, including high medical costs and lifestyle restrictions, while oleanolic acid (OA) is recognized as a natural anti-osteoporosis agent with unclear therapeutic mechanisms.
- This study investigates OA's anti-osteoporosis effects using a metabolomics approach on rats, focusing on biomarker identification and metabolic pathways linked to OA treatment.
- Results show OA improves clinical indicators and bone density, influencing key metabolic pathways and potentially restoring balance in carbohydrate and lipid metabolism disrupted by osteoporosis.