2 results match your criteria: "The Fourth Affiliated Hospital of Hebei Medical University Shijiazhuang[Affiliation]"
Case report: Analysis of novel compound heterozygous variants in a Chinese patient with neuronal ceroid lipofuscinosis type 2.
Front Genet
August 2022
Key Laboratory of Maternal and Fetal Medicine of Hebei Province, Institute of Reproductive Medicine of Shijiazhuang, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical University, Shijiazhuang, China.
Neuronal ceroid lipofuscinosis type 2 (CLN2) is an autosomal recessive neurodegenerative disease caused by variants in the gene that lead to the deficiency of the lysosomal enzyme tripeptidyl peptidase I (TPP1) activity. Herein, we report a rare case of CLN2 caused by two novel variants of . The patient presented with seizures at onset, followed by progressive cognitive impairment, motor decline, and vision loss.
View Article and Find Full Text PDFOverexpression of PTP4A1 is associated with poor overall survival in non-small cell lung cancer.
Int J Clin Exp Pathol
July 2018
The Fourth Affiliated Hospital of Hebei Medical University Shijiazhuang, Hebei Province, China.
Objective: We aimed to analyze the phosphatases of regenerating liver 1 (PTP4A1) expression and its relationship with tumor invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC).
Methods: The retrospective study enrolled 150 cases who underwent radical resection for primary NSCLC during the period from January 2006 to January 2014. Baseline characteristics of patients included age, gender, smoking history, pathological type, histological grade, clinical stage, and lymphatic metastasis.