5 results match your criteria: "The First People's Hospital of Jingzhou (First Affiliated Hospital of Yangtze University)[Affiliation]"
Identification of endocrine-disrupting chemicals targeting key OP-associated genes via bioinformatics and machine learning.
Ecotoxicol Environ Saf
November 2024
Department of Orthopedics, 3201 Hospital of Xi'an Jiaotong University Health Science Center, Hanzhong, China. Electronic address:
Osteoporosis (OP), a metabolic disorder predominantly impacting postmenopausal women, has seen considerable progress in diagnosis and treatment over the past few decades. However, the intricate interplay between genetic factors and endocrine disruptors (EDCs) in the pathogenesis of OP remains inadequately elucidated. The objective of this research is to examine the environmental pollutants and their regulatory mechanisms that could potentially influence the pathogenesis of OP, in order to establish a theoretical foundation for the targeted prevention and medical management of individuals with OP.
View Article and Find Full Text PDFIdentification of biomarkers associated with diagnosis of postmenopausal osteoporosis patients based on bioinformatics and machine learning.
Front Genet
July 2023
Department of Orthopedics, The First People's Hospital of Jingzhou (First Affiliated Hospital of Yangtze University), Jingzhou, China.
Article Synopsis
- Postmenopausal osteoporosis (PMOP) is a widespread bone disease with unclear molecular causes; this study sought to discover genetic diagnostic markers for it.
- The researchers combined three GEO datasets to find differentially expressed genes (DEGs) and used machine learning algorithms to identify candidate biomarkers, ultimately selecting ACACB and WWP1 for further analysis.
- These markers were validated through clinical samples and were linked to processes like amino acid synthesis and immune cell interactions, offering potential targets for future immunotherapy for PMOP.
Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration.
J Immunol Res
September 2022
Department of Orthopedics, The First People's Hospital of Jingzhou (First Affiliated Hospital of Yangtze University), Jingzhou, Hubei, China.
Background: With the extensive development of intervertebral disc degeneration (IDD) research, IDD has been found to be a complex disease associated with immune-related gene (IRGs) changes. Nonetheless, the roles of IRGs in IDD are unclear.
Methods: In our study, 11 IRGs were chosen using differential analysis between nondisc degeneration and degenerative patients from the GEO database.
iNOS Promotes the Development of Osteosarcoma via Wnt/-Catenin Pathway.
J Immunol Res
January 2022
Department of Orthopaedics, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.
Inducible nitric oxide synthase (iNOS), accompanied with protumor and antitumor activity, has been studied in multiple cancers. However, the role of iNOS expression in osteosarcoma (OS) is far from being fully understood. In present work, iNOS levels were detected in OS tissues and cell lines.
View Article and Find Full Text PDFIcariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the Xc-/GPX4 axis.
Exp Ther Med
January 2021
Department of Orthopedics, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu 730050, P.R. China.
The mechanism of action of synovitis, as the vital pathological process of rheumatoid arthritis and osteoarthritis, remains to be elucidated. The effects and the mechanism of icariin (ICA), which is a promising therapeutic agent in synovitis, was investigated in the present study. In addition, ferroptosis, a vital cell process involved in several diseases, was also studied in synovitis for the first time.
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