An inflammatory response-related gene signature associated with immune status and prognosis of acute myeloid leukemia.

Objective: To determine the prognostic significance of inflammatory response-associated genes in acute myeloid leukemia (AML).

Methods: Transcriptomic profiles and related clinical information of AML patients were acquired from a public database. To establish a multi-gene prognosis signature, we performed least absolute shrinkage and selection operator Cox analysis for the TCGA cohort and evaluated the ICGC cohort for verification.

Correlation between BOLD-MRI and HIF expression level in renal carcinoma.

Occupying about 2%~3% of all malignant tumors, renal carcinoma is the most common primary cancer in kidney. The oxidative level of tumor cells is of vital role for optimizing treatment plan, evaluating efficacy and predicting prognosis. This study thus investigated the R2(*) value in mouse renal carcinoma model and the correlation between tumor hypoxia and expression level of hypoxia inducible factor-1 (HIF-1).