415 results match your criteria: "The First Hospital of Qinhuangdao[Affiliation]"

The potential impact of inflammation on the lipid paradox in patients with acute myocardial infarction: a multicenter study.

BMC Med

December 2024

National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Rd, Beijing, 100037, Xicheng District, China.

Background: Low-density lipoprotein cholesterol (LDL-C) is a well-recognized risk factor for cardiovascular diseases. However, several clinical studies demonstrated an inverse association between LDL-C and mortality risk in patients with acute myocardial infarction (AMI), known as the lipid paradox. This study aims to investigate the potential impact of inflammation on the association between LDL-C levels and mortality risks.

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Purpose: The purpose of this study was to quantitatively evaluate the branching patterns and vascular fragmentation features in preclinical and early diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA).

Methods: OCTA metrics, including branch node number (BNN), branch node density (BND), end point number (EPN), end point density (EPD), fragmented vessel segment count (FVSC), and fragmented vascular length ratio (FVLR), were measured in foveal and parafoveal regions within superficial and deep vascular plexus (SVP and DVP) in the retina.

Results: Compared to healthy control (HCs), both BNN and BND exhibited a significant decrease in individuals with mild DR across both retinal layers, and also in diabetes mellitus without DR (no DR) within DVP.

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Aim: To develop a larynx preservation (LP) score model to predict laryngectomy-free survival (LFS) in advanced laryngeal squamous-cell carcinoma (LSCC) with morphological response to neoadjuvant chemotherapy (NAC).

Materials And Methods: In this retrospective study, patients with advanced LSCC were included. All patients were classified into NAC response and non-response groups according RECIST.

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Previous studies have reported an association between telomere length and non-alcoholic fatty liver disease (NAFLD). This study aimed to explore the involvement of alternative lengthening of telomere-related genes (ALTRGs) in the pathology of NAFLD, construct a risk signature, and evaluate both treatment and prognosis. Three NAFLD datasets (GSE48452, GSE89632, and GSE63067) were collected from the GEO database and merged into combined GEO datasets.

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  • A study investigated the effectiveness of combining sacubitril/valsartan with dapagliflozin in diabetic patients who developed heart failure after an acute myocardial infarction.
  • The research involved 80 patients split into two groups: one receiving standard treatment and the other the combination therapy, over a six-month period.
  • Results showed that the combination therapy was more effective in lowering blood glucose and improving heart function, suggesting it is a safe and beneficial option for this patient population.
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Although serum uric acid (SUA) is a risk factor for cardiometabolic outcome, but it remains unclear which patients with coronary artery disease (CAD) benefit the most from SUA lowering therapy (ULT). The association of SUA level, systemic inflammation and cardiometabolic risk is still unclear. The current study is aimed to examine whether SUA-associated cardiometabolic risk is modulated by systemic inflammation in CAD patients.

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  • A study explored the effectiveness of a deep learning (DL) algorithm for automatic segmentation of DCE-MRI images in differentiating BI-RADS 4 breast lesions, comparing it to manual segmentation.
  • Involving 197 patients, the DL model demonstrated high consistency with manual methods (Dice coefficient of 0.84) and outperformed professional radiologists in predictive accuracy with an area under the curve (AUC) of 0.85.
  • The DL model not only provided better diagnostic results but also significantly increased efficiency, reducing the time needed for segmentation by 83.2%, indicating a promising future for clinical use in breast cancer diagnosis.
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Background: The optimal glycosylated hemoglobin (HbA1c) target in type 2 diabetes mellitus (T2DM) patients remains controversial, especially in patients with concomitant coronary heart disease (CHD). This study aimed to investigate the correlation between baseline HbA1c and long-term prognosis in CHD patients with T2DM.

Methods: The study enrolled 6,839 CHD patients with T2DM and measured HbA1c at admission in a multicenter prospective observational cohort.

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The incidence of laryngeal squamous cell carcinoma (LSCC) has been rising recently. LSCC is one of the most prevalent malignant tumors of the head and neck. In this study, we aimed to investigate whether tripartite motif containing 71 (TRIM71) could serve as a molecular target for the treatment of LSCC.

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Background: All-inside cruciate ligament reconstruction is an emerging technique for treating anterior cruciate ligament and posterior cruciate ligament injuries. The all-inside technique uses a 4-stranded graft made of a single tendon that wraps around itself. Four strands of the graft must be immobilized to form a closed loop, and the free ends of the graft must be attached using a suture technique.

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Dose-response relationship between the fatty liver index and asthma risk: NHANES 2001~2018.

Endocr J

November 2024

Department of Pulmonary and Critical Care Medicine, The First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei, China.

The correlation of obesity and metabolic abnormalities with asthma and non-alcoholic hepatic steatosis has been extensively studied. However, the association between asthma and non-alcoholic hepatic steatosis has been largely overlooked. This study aims to investigate the potential association between asthma risk and the fatty liver index (FLI), a validated indicator of non-alcoholic fatty liver disease (NAFLD).

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Purpose: To investigate the relationship between obesity indices and sarcopenia in postmenopausal patients with type 2 diabetes mellitus (T2DM) at different body mass index (BMI) levels.

Patients And Methods: This retrospective cross-sectional study included 298 hospitalized postmenopausal women diagnosed with T2DM. We collected demographic, biochemical, and anthropometric data on each subject.

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Background: Concurrent chemoradiotherapy (CCRT) is used as the primary treatment modality for currently limited cervical cancer and lacks non-invasive quantitative parameters to assess clinical outcomes of treatment for cervical cancer treatment.

Purpose: To develop nomograms based on clinical prognostic factors and apparent diffusion coefficient (ADC) in predicting downstaging and progression-free survival (PFS) after CCRT for cervical cancer.

Material And Methods: X-tile was used to calculate the optimal threshold for ΔADC(%) for prognostic stratification.

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Repeated high-dose esketamine in early postnatal rats leads to behavioural deficits with long-term modifications in white matter microstructural integrity.

Brain Res

January 2025

Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China; Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Shijiazhuang 050000, China; Key Laboratory of Clinical Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang 050000, China. Electronic address:

Esketamine is commonly used for sedation or general anaesthesia in infants and young children. However, repeated esketamine administration during periods of rapid brain growth and development may result in various pathophysiological and cognitive changes. Therefore, this study aimed to investigate the influence of recurrent esketamine exposure on long-term behavioural and white matter consequences.

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Article Synopsis
  • This study explored the relationship between BTK/YKL-40 levels and the severity of AQP4-IgG + NMOSD, aiming to find biomarkers that could be useful for monitoring the disease and assessing treatment.
  • Plasma YKL-40 levels in acute-phase NMOSD patients before treatment were notably higher compared to those after treatment, in remission, or in healthy individuals, indicating its role in disease severity.
  • The research found strong correlations between elevated YKL-40, BTK, and NF-κB levels with increased disability scores, suggesting these biomarkers could predict disease activity and treatment response in NMOSD patients.
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Purpose: The aim of this study was to characterize the biomechanical properties of a novel side-to-side tenorrhaphy (SST), this tenorrhaphy is designed to achieve reliable strength utilizing fewer knots and greater operationalization. This is compared with a well-established tendon reconstruction technique called the Pulvertaft weave technique (PWT).

Methods: Twenty fresh porcine hindfoot flexor tendons were collected, and 10 novel SST and 10 PWT were performed in each group.

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[Effect of Xuebijing injection on acute gastrointestinal injury in patients with sepsis: a retrospective cohort study].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue

September 2024

Department of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China. Corresponding author: Zuo Zhigang, Email:

Article Synopsis
  • The study aimed to observe how Xuebijing injection affects patients with sepsis and acute gastrointestinal injury (AGI) and to identify risk factors for this condition.
  • It involved a retrospective analysis of 129 patients with non-gastrointestinal sepsis, who were divided into those receiving Xuebijing injection and those who were not, as well as those with AGI and those without.
  • Results indicated no significant differences in demographics or underlying conditions between the two groups receiving and not receiving Xuebijing, and the study will explore further differences in treatment effects and outcomes.
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To investigate the treatment outcomes of combined internal and external fixation surgery for patients with posterior lateral tibial plateau fractures and explore its safety. The study was conducted from February 2020 to February 2023 and included a total of 77 patients with Schatzker IV and Schatzker V type posterior lateral tibial plateau fractures. Patients were divided into control group and treatment group according to different treatment methods: the control group with 38 cases received treatment with dual-support plates, and the study group with 39 cases received treatment with internal fixation using medial plates combined with lateral locking plates.

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Introduction: Accumulating evidence suggests the significant involvement of GADD45G in the development of various cancers. This study investigates GADD45G's involvement and methylation status in endometrial cancer (EC), along with molecular mechanisms and potential therapies.

Methods: The expression of GADD45G in EC tissues and controls was evaluated using RNA-seq, quantitative real-time polymerase chain reaction (qRT-PCR), and western blotting (WB).

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Vitamin D level as a predictor of dysmobility syndrome with type 2 diabetes.

Sci Rep

August 2024

The First Hospital of Qinhuangdao, No.258 Wenhua Road, Qinhuangdao, 066000, Hebei Province, People's Republic of China.

Dysmobility Syndrome (DMS), is a combination, that is analogous to the approach taken with metabolic syndrome, The diagnosis of DMS is complex. So this study aimed to explore the relationship between 25-(OH) Vit D with Dysmobility Syndrome (DMS)in type 2 diabetes mellitus(T2DM) patients. This is a cross-sectional study, including 330 patients (67.

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Article Synopsis
  • Some clinicians use endografts to partially cover the left subclavian artery (LSA) during TEVAR treatment to address issues with the proximal landing zone (PLZ).
  • A computational fluid dynamics (CFD) study was conducted to observe the hemodynamic changes in the LSA following this procedure, revealing factors that could lead to thrombosis or arteriosclerosis.
  • Results showed that covering half the LSA ostium increased local blood flow velocity, decreased wall shear stress, and created turbulent blood flow, suggesting that this approach could heighten long-term health risks such as stroke.
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Aim: To analyze the distribution of fibrovascular proliferative membranes (FVPMs) in proliferative diabetic retinopathy (PDR) patients that treated with pars plana vitrectomy (PPV), and to evaluate the outcomes separately.

Methods: This was a retrospective and cross-sectional study. Consecutive 25-gauge (25-G) PPV cases operated for PDR from May 2018 to April 2020.

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Article Synopsis
  • A 71-year-old man developed severe pneumonia and pulmonary abscesses after experiencing epididymitis due to an infection with extended spectrum β-lactamase-producing hypervirulent Klebsiella pneumoniae (ESBL-hvKp), a drug-resistant bacteria.
  • The patient initially received anti-infection treatment but failed to respond, leading to a need for prolonged therapy, which he ultimately chose to discontinue.
  • This case highlights how an infection starting from the epididymis can spread through the bloodstream, causing severe lung complications and posing significant treatment challenges.
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