10 results match your criteria: "The First Hospital Affiliated to Zhejiang Chinese Medical University[Affiliation]"
Better pre-transplant treatment options for TP53-mutated MDS: cytoreductive or non-cytoreductive therapy?
Bone Marrow Transplant
December 2024
Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- * A study analyzed 284 MDS patients, finding no significant survival benefits from cytoreductive treatment before HSCT compared to those receiving best supportive care (BSC).
- * Ultimately, whether patients underwent cytoreduction or BSC, their post-transplant outcomes were similar, indicating that this treatment approach does not improve prognosis for TP53-mutated MDS patients.
Discovery of potential ferroptosis and osteoporosis biomarkers through TMT proteomics and bioinformatics analysis.
Biomed Eng Online
November 2024
Department of Spine and Spinal Cord, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, Shandong, China.
Article Synopsis
- Primary osteoporosis is a significant health concern that involves complex mechanisms, with ferroptosis emerging as a key area of research connecting its pathogenesis.
- The study utilized a model of ovariectomized rats to investigate the relationship between ferroptosis and primary osteoporosis through TMT proteomics and bioinformatics, identifying significant protein expression changes in bone tissues.
- Results showed that lipid metabolism disruptions and oxidative stress linked to iron metabolism may play a crucial role in the development of osteoporosis, highlighting potential target genes for further research.
Comparison of the prognostic predictive value of Molecular International Prognostic Scoring System and Revised International Prognostic Scoring System in patients undergoing allogeneic hematopoietic stem cell transplantation for myelodysplastic neoplasms.
Am J Hematol
December 2023
Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Comparison of clinical efficacy between direct anterior approach and posterolateral approach in primary total hip arthroplasty.
Eur Rev Med Pharmacol Sci
June 2023
Department of Traumatology and Orthopedics, The First Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Objective: The aim of this study was to retrospectively analyze the clinical efficacy of the direct anterior approach (DAA) vs. posterolateral approach (PLA) in primary total hip arthroplasty (THA).
Patients And Methods: A total of 382 patients who underwent primary THA in our hospital from March 2016 to March 2021 were identified as research subjects, with 183 patients in the DAA group and 199 in the PLA group.
Alterations in the gut microbiota of AIDS patients with pneumocystis pneumonia and correlations with the lung microbiota.
Front Cell Infect Microbiol
November 2022
Department of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Background: Due to the inability to be cultured , the biological characteristics and pathogenicity of remain unclear. Intestinal microflora disorder is related to the occurrence and development of various pulmonary diseases. This work explores the pathogenesis of pneumocystis pneumonia (PCP) in acquired immune deficiency syndrome (AIDS) patients from a microbiome perspective, to provide better strategies for the diagnosis, treatment, and prevention of PCP.
View Article and Find Full Text PDFOutcome after allogeneic hematopoietic stem cell transplantation following Venetoclax-based therapy among AML and MDS patients.
Ann Hematol
December 2022
Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
The use of Bcl-2 inhibitor Venetoclax (VEN) combined with hypomethylating agents or chemotherapy has shown efficacy in treating acute myeloid leukemia (AML) as frontline treatment and for relapse, allowing more patients to bridge to allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the influence of VEN-based therapy on the prognosis of subsequent allogeneic HSCT remains unknown. We retrospectively collected data from patients who proceeded to allo-HSCT between November 2018 and November 2020 after VEN-based therapy at five transplant centers in Zhejiang Province, China.
View Article and Find Full Text PDFInflammation, angiogenesis and sensory nerve sprouting in the synovium of bony ankylosed and not bony ankylosed knees with end-stage haemophilic arthropathy.
Haemophilia
July 2021
Department of Orthopedic Surgery, The First Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Article Synopsis
- Patients with bony ankylosed knees (BA-group) experienced significantly lower pain levels compared to those with non-bony ankylosed knees (Not-BA-group), as indicated by their visual analogue scale (VAS) scores.
- The study involved collecting synovial samples during total knee arthroplasty from 52 end-stage haemophilic arthropathy cases, analyzing both pain sensation and histopathological differences.
- Histopathological analysis revealed that Not-BA-group showed increased synovial thickness and higher expression levels of inflammatory markers compared to the BA-group, suggesting a link between joint stiffness and reduced pain perception.
Pathological mechanism of joint destruction in haemophilic arthropathy.
Mol Biol Rep
January 2021
Department of Orthopedic Surgery, The First Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Article Synopsis
- Haemophilic arthropathy (HA) is a common complication in hemophilia patients, triggered by bleeding into the joints and resulting in severe pain and reduced quality of life.
- Factor replacement therapy helps prevent joint bleeding in children, but many in developing countries still face HA due to limited access to treatment.
- The condition's complex pathology involves inflammation, synovitis, and damage to bones and cartilage, highlighting the need for further research to understand and address these mechanisms.
[Risk factors analysis for steroid-resistant acute graft versus host disease after haploidentical hematopoietic stem cell transplantation].
Zhonghua Xue Ye Xue Za Zhi
February 2020
Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
To analyze the risk factors of steroid resistant acute graft- versus-host disease (aGVHD) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT) . The clinical data of adult patients with acute myeloid leukemia (AML) /Myelodysplastic syndrome (MDS) who developed aGVHD after haplo-HSCT in Peking University Institute of Hematology from January 1st, 2010 to December 31st, 2012 were retrospectively reviewed. A total of 85 patients were enrolled in the study, including 55 males and 30 females, with a median age of 30 (19-67) years.
View Article and Find Full Text PDFQian Five Rhinoceros Gindeng (QFRG) protects against development of immune thrombocytopenia via miR-181a inhibition of TLR-4 expression.
Int J Clin Exp Med
July 2015
Department of Emergency, The First Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou 310006, Zhejiang, China.
Aims: Traditional Chinese medicine (TCM) has been considered to be effective auxiliary strategy for the treatment of hemocytopenia including immune thrombocytopenia. However, the molecular mechanism is still not understood.
Methods: In present study, Qian Five Rhinoceros Gindeng (QFRG) mainly containing buffalo horn, rehmannia root, radix rubia, trogopterus dung and radix salviae miltiorrhizae administrated to thrombocytopenia mice induced by injection of MWReg30.