624 results match your criteria: "The First Clinical Medical College of Lanzhou University[Affiliation]"
Dig Liver Dis
December 2024
Lanzhou First People's Hospital, Gansu, 730050, China. Electronic address:
Cell Biochem Funct
December 2024
School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Autophagy is an essential intracellular degradation system responsible for delivering cytoplasmic components to lysosomes. Within this intricate process, optineurin (OPTN), an autophagy receptor, has attracted extensive attention due to its multifaceted roles in the autophagy process. OPTN is regulated by various posttranslational modifications and actively participates in numerous signaling pathways and cellular processes.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2025
Department of Obstetrics and Gynecology, First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou, 730000, Gansu, China; Department of Obstetrics and Gynecology, First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China. Electronic address:
Endometrial carcinoma (EC), a prevalent gynecological cancer, is characterized by rising incidence and mortality rates, highlighting the need for novel treatments to improve patient outcomes. Maackiain (MA) is a natural compound isolated from common herbal medicines, that has been reported to have anti-cancer effects. However, the underlying roles and mechanisms concerning EC remain unclear.
View Article and Find Full Text PDFActa Cardiol
December 2024
Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Objective: The relationship between vascular endothelial function and bone mineral density (BMD) in T2DM patients with metabolic dysfunction associated fatty liver (MAFLD) is still unclear. This study aims to analyse the correlation between vascular endothelial function and BMD or fracture risk in T2DM patients with MAFLD.
Methods: A total of 872 T2DM patients aged ≥50 years were enrolled and divided into two groups according to the diagnostic criteria of MAFLD: MAFLD (+) and MAFLD (-).
Heliyon
November 2024
Division of Hematology, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Saikosaponin A (SSA), the primary active monomer derived from the Radix bupleuri, demonstrates a diverse array of pharmacological activities, including anti-inflammatory, antitumor, analgesic, anti-fibrotic, antidepressant, and immune-modulating properties. Despite its potential therapeutic impact on various human diseases, comprehensive studies exploring SSA's efficacy in these contexts remain limited. This review synthesizes the current research landscape regarding SSA's therapeutic applications across different diseases, highlighting critical insights to overcome existing limitations and clinical challenges.
View Article and Find Full Text PDFTransl Stroke Res
December 2024
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Adv Sci (Weinh)
December 2024
School of Medicine, Hangzhou City University, Hangzhou, 316021, China.
JAMA Pediatr
December 2024
The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Rev Cardiovasc Med
November 2024
The First Clinical Medical College of Lanzhou University, 730000 Lanzhou, Gansu, China.
Int Immunopharmacol
January 2025
Department of Sports Medicine, Honghui Hospital, Xi'an Jiao Tong University, 710054 Xi'an, Shaanxi Province, China. Electronic address:
Osteosarcoma is a common primary malignant bone tumor with a high incidence in children and adolescents, with high invasiveness and lung metastases. Even after traditional surgical excision, chemoradiotherapy, and comprehensive treatment, the survival rate of patients is still low, and the prognosis is not ideal. As an important part of non-coding RNA family, lncRNA and miRNA have significant regulatory effects on the growth, proliferation, metastasis and apoptosis of osteosarcoma cells.
View Article and Find Full Text PDFSci Rep
November 2024
Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730030, China.
Distal cholangiocarcinoma is a rare and highly aggressive malignant tumor. The inherent tumor characteristics and growth pattern of cancer cells pose a challenge for diagnosis and treatment. Chemotherapy resistance leads to limited treatment options for patients with advanced cholangiocarcinoma.
View Article and Find Full Text PDFMedicine (Baltimore)
November 2024
Hunan University of Medicine, Huaihua, China.
Background: Diabetic nephropathy (DN) is a common complication of diabetes, which is prone to develop into end-stage renal disease, and early diagnosis and treatment is the key to effective management of DN. Biomarkers have important clinical significance in the diagnosis and treatment of DN and have attracted extensive attention from researchers in recent years. The aim of this study was to visualize the field of biomarker research in DN through bibliometric analysis, to summarize the current status and predict future trends of this field, with a view to providing valuable insights for scholars and policy makers.
View Article and Find Full Text PDFStem Cell Res Ther
November 2024
The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
BMC Anesthesiol
November 2024
Department of Anesthesia and Surgery, First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China.
Inflamm Bowel Dis
November 2024
Lanzhou First People's Hospital, Lanzhou, Gansu 730050, China.
Urology
November 2024
Department of Urology, Gansu Provincial Hospital, Lanzhou 730000, China.
Comput Methods Programs Biomed
January 2025
The First Clinical Medical College of Lanzhou University, 199 Donggang West Road, Lanzhou 730000, China; Department of Cardiovascular Surgery, First Hospital of Lanzhou University, 1 Donggang West Road, Lanzhou 730000, China. Electronic address:
Hypertension is a major preventable risk factor for cardiovascular disease, affecting over 1.5 billion adults worldwide. Antihypertensive peptides (AHTPs) have gained attention as a natural therapeutic option with minimal side effects.
View Article and Find Full Text PDFEur J Surg Oncol
January 2025
Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao City, Shandong Province, 266000, China. Electronic address:
Objectives: The research aimed to create and verify a nomogram model that can predict the likelihood of cholangiocarcinoma with microvascular invasion (MVI).
Methods: The clinical data of 476 patients with surgically confirmed cholangiocarcinoma were collected retrospectively. This included 240 cases of intrahepatic cholangiocarcinoma (iCCA), 85 cases of perihilar cholangiocarcinoma (pCCA), and 151 cases of extrahepatic cholangiocarcinoma (eCCA).
Ann Noninvasive Electrocardiol
November 2024
Department of Geriatric Cardiology, The First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Geriatric Diseases, Lanzhou, Gansu, China.
Purpose: This study aims to scrutinize the association between various Insulin Resistance (IR) indices and heart failure (HF) risk in adult diabetics within the United States.
Methods: The National Health and Nutrition Examination Survey (NHANES) (2005-2018) dataset was used in this study. Weighted logistic regression analysis and restricted cubic spline were employed to ascertain the correlation between IR indices and the incidence of HF in diabetic patients.
Sci Rep
November 2024
Geriatric Cardiovascular Department and Gansu Clinical Research Center for Geriatric Diseases, First Hospital of Lanzhou University, Gansu, China.
The aim of this study was to investigate the relationship between red blood cell distribution width and albumin ratio (RAR) levels and mortality in adult patients with sarcopenic obesity in the United States. The study included 1,361 adult patients with sarcopenic obesity from the National Health and Nutrition Examination Survey (1999-2006). The X-tile was used to determine the optimal subgroup thresholds for RAR values, and propensity score matching (PSM) was employed to reduce baseline bias.
View Article and Find Full Text PDFGeburtshilfe Frauenheilkd
November 2024
The First Clinical Medical College of Lanzhou University, the First Hospital of Lanzhou University, Lanzhou City, Gansu Province, China.
Pharmacol Ther
December 2024
The First Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China. Electronic address:
Cancer neuroscience, as an emerging converging discipline, provides us with new perspectives on the interactions between the nervous system and cancer progression. As the sympathetic nervous system, in particular adrenergic signaling, plays an important role in the regulation of tumor activity at every hierarchical level of life, from the tumor cell to the tumor microenvironment, and to the tumor macroenvironment, it is highly desirable to dissect its effects. Considering the far-reaching implications of drug repurposing for antitumor drug development, such a large number of adrenergic receptor antagonists on the market has great potential as one of the means of antitumor therapy, either as primary or adjuvant therapy.
View Article and Find Full Text PDFJ Inflamm Res
October 2024
The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province, People's Republic of China.
Sepsis is a common critical illness characterized by high mortality rates and a significant disease burden. In the context of sepsis-induced organ dysfunction, the lungs are among the initial organs affected, which may progress to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Recent studies have highlighted the crucial roles of mitophagy and ferroptosis in the development and progression of sepsis-induced ALI/ARDS.
View Article and Find Full Text PDFWorld J Psychiatry
October 2024
Department of Neurology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
Background: Acute ischemic stroke (AIS) is a significant global health issue with increasing incidence owing to aging populations and rising cardiovascular risk factors. In addition to physical impairments, AIS frequently leads to neuropsychiatric complications, such as cognitive impairment, anxiety, and depressive symptoms, which adversely affect patients' quality of life and rehabilitation. Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a potential biomarker for various conditions, including AIS.
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