7,726 results match your criteria: "The First Affiliated Hospital of Wenzhou Medical[Affiliation]"
Clinical and genetic spectrum of factor XII deficiency in the Han population of East China.
Orphanet J Rare Dis
October 2024
Department of Blood Transfusion, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China.
Background: Factor XII (FXII or F12) deficiency is a rare inherited disorder, typically lacking haemorrhagic symptoms. There is limited literature exists on FXII deficiency and mutations within the Chinese population. This study aimed to characterize the spectrum of F12 gene mutations in a Chinese cohort and to investigate the relationship between FXII mutations and clinical phenotypes.
View Article and Find Full Text PDFOptimal surgical timing for lung cancer following SARS-CoV-2 infection: a prospective multicenter cohort study.
BMC Cancer
October 2024
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, No.507 Zhengmin Road, Yangpu District, Shanghai, 200433, China.
Article Synopsis
- A study was conducted to evaluate the best timing for lung cancer surgery during the Omicron variant period, focusing on the relationship between prior SARS-CoV-2 infection and surgical outcomes.
- The research involved 2081 patients, revealing that those infected with COVID-19 before surgery experienced higher rates of complications if surgery occurred 4-7 weeks after infection, while surgeries 8 weeks or later showed similar risks to those without prior infection.
- The findings suggest that careful consideration of individual risks is necessary for optimal surgical planning in lung cancer patients with a history of SARS-CoV-2 infection.
Vision transformer introduces a new vitality to the classification of renal pathology.
BMC Nephrol
October 2024
Department of Nephrology, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang, PR China.
Article Synopsis
- Recent advancements in AI, particularly in computer vision, are being applied to medical fields, but classifying renal pathology is still challenging due to subtle differences in types.
- The study developed a Vision Transformer (ViT) model using 1861 stained renal histopathology images from 635 patients, categorizing them into 14 different classes.
- Results showed that the ViT model significantly outperformed traditional CNN models in accuracy (0.96-0.99) and demonstrated an ability to highlight important pathological structures, aiding in the diagnosis and treatment of renal diseases.
Environmental chemical exposures and a machine learning-based model for predicting hypertension in NHANES 2003-2016.
BMC Cardiovasc Disord
October 2024
Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Hospital District, Ouhai District, Wenzhou City, 325000, Zhejiang Province, China.
Background: Hypertension is a common disease, often overlooked in its early stages due to mild symptoms. And persistent elevated blood pressure can lead to adverse outcomes such as coronary heart disease, stroke, and kidney disease. There are many risk factors that lead to hypertension, including various environmental chemicals that humans are exposed to, which are believed to be modifiable risk factors for hypertension.
View Article and Find Full Text PDFNrf2 inhibits M1 macrophage polarization to ameliorate renal ischemia-reperfusion injury through antagonizing NF-κB signaling.
Int Immunopharmacol
December 2024
Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China. Electronic address:
Article Synopsis
- * Nrf2 plays a vital role in reducing inflammation and oxidative stress, and its inhibition leads to worse inflammatory responses during renal IRI, as evidenced by increased NF-κB signaling activity.
- * The study found that activating Nrf2 can reduce M1 macrophage polarization and mitigate the severity of renal IRI, suggesting that promoting Nrf2 activity could be a promising treatment strategy.
Corynoxine exerts the anti-tumor effect on esophageal squamous cell carcinoma principally via the EZH2-DUSP5-ERK1/2-mediated cell growth inhibition.
Phytomedicine
December 2024
Department of Thoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China. Electronic address:
Background: Esophageal cancer is one of the most prevalent malignant tumors and the sixth largest cause of tumor-associated death worldwide. Squamous cell carcinoma (ESCC) accounts for 85 % of all esophageal cancer cases. ESCC treatment remains to be significantly difficult.
View Article and Find Full Text PDFS100A2 activation promotes interstitial fibrosis in kidneys by FoxO1-mediated epithelial-mesenchymal transition.
Cell Biol Toxicol
October 2024
Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China.
Background: Renal interstitial fibrosis (RIF) is a common feature of chronic kidney diseases (CKD), with epithelial-mesenchymal transition (EMT) being one of its important mechanisms. S100A2 is a protein associated with cell proliferation and differentiation, but its specific functions and molecular mechanisms in RIF remain to be determined.
Methods: S100A2 levels were evaluated in three mouse models, including unilateral ureteral obstruction (UUO), ischemia-reperfusion injury (IRI), and aristolochic acid nephropathy (AAN), as well as in TGF-β1- treated HK-2 cells and in kidney tissue samples.
Changes in immune status of circulating NK cells in patients with latent tuberculosis infection.
Cent Eur J Immunol
August 2024
Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, China.
Introduction: The presence of patients with latent tuberculosis infection (LTBI) has fueled the tuberculosis pandemic. We aimed to investigate the immune status of NK cells in LTBI patients.
Material And Methods: Twenty-one LTBI patients, 25 active pulmonary tuberculosis (APTB) patients and 25 healthy controls (HCs) participated in our research.
LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway.
Sci Rep
October 2024
Department of Cardiology, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Background: Histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDAC5) are two isoforms of class IIa HDACs, and LMK235 is an HDAC inhibitor with higher selectivity for HDAC4/5. This study aimed to explore the expression and subcellular localization of HDAC4/5 and determine the mechanisms underlying the impact of LMK235 on ventricular remodelling post-MI.
Methods: The MI model was established by left anterior descending branch (LAD) ligation, and LMK235 or vehicle was intraperitoneally injected daily for 21 days.
High-throughput screening identified pacritinib as a promising therapeutic approach to overcome lenvatinib resistance in hepatocellular carcinoma by targeting IRAK1.
Biochem Biophys Res Commun
November 2024
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:
Article Synopsis
- Lenvatinib resistance is a big problem when treating advanced liver cancer (HCC), so scientists created specific resistant cancer cells to study the issue.
- They found that pacritinib, an anti-cancer drug, worked really well against these resistant cells and didn't harm normal liver cells much.
- Pacritinib not only helped decrease cancer cell growth but also worked better when used with lenvatinib, making it a potential new treatment option for patients with tough-to-treat liver cancer.
FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.
Front Pharmacol
September 2024
Department of Wound Repair, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Article Synopsis
- Ferroptosis is a newly identified form of cell death linked to lipid damage and iron dependency, complicating the healing process of peripheral nerve injuries (PNI) due to mitochondrial dysfunction.
- This study used in vitro (Schwann cells) and in vivo (sciatic nerve injury in rats) models to examine how fibroblast growth factor 21 (FGF21) affects PNI and its connection to ferroptosis and mitochondrial issues.
- Results showed that PNI leads to harmful lipid reactive oxygen species and mitochondrial dysfunction, but FGF21 can alleviate these effects and promote nerve repair by inhibiting ferroptosis, suggesting that targeting mitochondria and ferroptosis could be a new way to treat such injuries.
Diagnostic accuracy of exhaled nitric oxide for the non-invasive identification of patients with fibrotic metabolic dysfunction-associated steatohepatitis.
Ann Med
December 2024
MAFLD Research Centre, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Article Synopsis
- Fibrotic metabolic dysfunction-associated steatohepatitis (MASH) is a liver condition that can lead to severe disease, and researchers explored the use of an exhaled nitric oxide (eNO) breath test to diagnose fibrotic MASH without needing blood tests.
- In a study involving 147 patients, the eNO test demonstrated diagnostic capabilities similar to existing blood-based methods (FAST, Agile 3, and FIB-4 scores), showing an area under the curve around 0.737.
- The eNO test provided high sensitivity and specificity thresholds for diagnosing fibrotic MASH, and combining it with liver stiffness measurement increased its diagnostic accuracy.
Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis.
Nat Commun
October 2024
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- Primary biliary cholangitis (PBC) is a serious disease affecting the liver, causing inflammation and damage over time.
- Scientists used a special technique called single-cell RNA sequencing to study immune cells in PBC patients and learned more about how the disease damages the liver.
- They found that certain cells in the liver are involved in the problem and blocking a specific pathway could help reduce inflammation and improve the situation in experiments.
[A case of subacute phosphate nephropathy caused by oral sodium phosphate].
Zhonghua Nei Ke Za Zhi
October 2024
Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Institute of Chronic Kidney Disease, Wenzhou Medical University, Wenzhou 325000, China.
Letter to the editor concerning "Sarcopenia and its effects on outcome of lumbar spine surgeries" by Gaddikeri et al. (Eur Spine J [2024]: doi: 10.1007/s00586-024-08155-3).
Eur Spine J
January 2025
Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, Zhejiang Province, P.R. China.
When Chinese patients with plasma cell disorders encountered the nationwide Omicron outbreak (December 2022): a real-world multicenter and multiregional study.
Hematology
December 2024
Department of Hematology and Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Article Synopsis
- A study looked at how the Omicron COVID-19 outbreak in December 2022 affected patients in China with plasma cell disorders (PCD).
- Out of 404 patients, most got COVID-19, and some had severe cases, especially older patients and those who recently had certain treatments.
- The findings show that PCD patients are more at risk during the Omicron wave, so it's important to take extra care of them.
HO Self-Supplied MoS/CaO Nanozyme Hydrogel with Near-Infrared Photothermal Synergetic Cascade Peroxidase-Like Activity for Wound Disinfection.
Adv Healthc Mater
October 2024
Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, P. R. China.
Article Synopsis
- The study highlights the limitations of existing nanocatalysts in wound healing due to low reactive oxygen species (ROS) generation, presenting a new nanocomposite (M/C/AEK) made of molybdenum disulfide decorated with calcium peroxide.
- This nanocomposite enhances wound treatment by producing hydroxyl radicals in response to the acidic environment of wounds, selectively targeting infected areas while minimizing damage to healthy tissue.
- The M/C/AEK hydrogel not only captures bacteria effectively but also promotes healing through its Ca ions and keratin, showcasing its potential for advanced wound care and infection control.
Methacrylated hyaluronic acid/laponite photosensitive, sustained-release hydrogel loaded with bilobalide for enhancing random flap survival through mitigation of endoplasmic reticulum stress.
Int J Biol Macromol
November 2024
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, PR China; The Second School of Medicine of Wenzhou Medical University, Wenzhou 325000, PR China; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou 325000, PR China. Electronic address:
Random flaps are extensively utilized in plastic surgery due to their flexibility compared to traditional axial vascular system arrangements and their resemblance to injured skin in color, thickness, and texture. Despite these advantages, they are susceptible to ischemia-reperfusion injuries and subsequent necrosis post-transplantation. Bilobalide (BB), a sesquiterpene compound derived from Ginkgo biloba, exhibits notable antioxidant and anti-inflammatory properties and is commonly used to treat ischemiareperfusion injuries.
View Article and Find Full Text PDFA novel format of TNF-α binding affibody molecule ameliorate coronary artery endothelial injury in a mouse model of Kawasaki disease.
Int J Biol Macromol
November 2024
Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Structural Malformations in Children of Zhejiang Province, 325027 Wenzhou, Zhejiang, China; Children's Heart Center, Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Article Synopsis
- Kawasaki disease (KD) is an autoimmune condition that affects blood vessels and can lead to heart issues, prompting research into new treatment methods like anti-TNFα monoclonal antibodies.
- A novel therapeutic agent, an affibody designed to target TNF-α, was developed and showed strong binding and neutralizing effects against TNF-α, differentiating it from traditional mAbs.
- The engineered affibody, known as ZTAT, demonstrated effectiveness in treating KD-related endothelial injury, showcasing potential as a cost-effective therapeutic option with a longer serum half-life.
Araloside A alleviates sepsis-induced acute lung injury via PHD2/HIF-1α in macrophages.
Phytomedicine
December 2024
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, 277#, Yanta West Road, Xi'an, Shaanxi Province, China. Electronic address:
Background: Acute lung injury (ALI)-induced acute respiratory syndromes is a critical pathological sequala of sepsis. Araloside A (ARA), extracted from Aralia taibaiensis, possesses anti-oxidative and pro-apoptotic effects, as well as a protective effect against inflammatory diseases such as gastric ulcers. However, its impact on progression of ALI remains unknown.
View Article and Find Full Text PDFEffect of recombinant CYP3A4 variants and interaction on imatinib metabolism in vitro.
Biomed Pharmacother
November 2024
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:
The aim of this study was to investigate the catalytic activity of 26 Cytochrome P450 3A4 (CYP3A4) variants and drug interactions on imatinib metabolism in recombinant insect microsomes. This study was designed with an appropriate incubation system and carried out in the constant temperature water. By using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) to measure the quantities of its metabolite N-desmethyl imatinib, to elucidate the impacts of the CYP3A4 genetic polymorphism and drug interactions on the metabolism of imatinib.
View Article and Find Full Text PDFacFibroMASH Index for the Diagnosis of Fibrotic MASH and Prediction of Liver-related Events: An International Multicenter Study.
Clin Gastroenterol Hepatol
October 2024
MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, Zhejiang, China. Electronic address:
Article Synopsis
- Scientists studied a health problem called MASH, which affects people's livers, and worked on two tests to help doctors tell if someone has it.
- They looked at data from over 3,000 people to make sure their first test, called acMASH, worked well, and then created a new test called acFibroMASH to find more severe cases.
- The new acFibroMASH test was better at predicting who might have future liver problems compared to another test, showing it's a useful tool for doctors to keep patients healthy.
Exploring genetic and immune cell dynamics in systemic lupus erythematosus patients with Epstein-Barr virus infection via machine learning.
Rheumatology (Oxford)
October 2024
Department of Rheumatology and Immunology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Article Synopsis
- * Researchers used data from various studies to perform differential gene expression analysis, machine learning, and immune cell infiltration assessments, identifying 58 overlapping differentially expressed genes.
- * IFI27 was highlighted as a key gene with strong diagnostic potential in SLE patients with EBV infection, linked to changes in CD4 T cells and B cell types, which may offer new targets for diagnosis and treatment.
Analysis of riociguat and desmethyl riociguat by UPLC-MS/MS and its interaction with quercetin.
Front Pharmacol
September 2024
Department of Pharmacy, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, China.
Article Synopsis
- Riociguat is a medication used for treating pulmonary hypertension and a new method was developed to accurately measure its levels and its metabolite in plasma.
- The study also explored the interaction between riociguat and quercetin, a compound known for its anticancer properties that may help with pulmonary hypertension symptoms.
- Results indicated that quercetin significantly hinders the metabolism of riociguat and its metabolite in rats, leading to higher levels of these substances in the bloodstream.