48 results match your criteria: "The First Affiliated Hospital of Tsinghua University[Affiliation]"

Background: Given the distinctive physiological characteristics of pregnant women, non-pharmacological therapies are increasingly being used to improve depressive and anxiety symptoms. Our objective was to explore and compare the impact of various non-pharmacological interventions in improving depressive and anxiety symptoms, and to identify the most effective strategies for pregnant women with depressive and/or anxiety symptoms.

Methods: We conducted a systematic search of PubMed, Embase, the Cochrane Library, and Web of Science for randomized controlled trials (RCTs) that compared non-pharmacological interventions to usual care, from the inception of each database up to October 5, 2024.

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The effect of a new thinking guidance of OPACCUS for shock on the 30-day mortality: A multicenter, prospective, observational, cohort study.

Eur J Intern Med

December 2024

Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, PR China. Electronic address:

Objectives: The purpose of this study was to determine whether our new thinking guidance named OPACCUS (oxygen metabolism, perfusion, arterial tension, cardiac output, systemic congestion, unregulated host response and search for inciting illness event) with 7 questions you need to ask before shock therapy and evidences provided by critical ultrasound considering hemodynamics, the unregulated host response and inciting illness event would improve mortality in shock patients.

Design: A multicenter, prospective, observational cohort study.

Setting: Intensive care units of 20 hospitals in Southwest China.

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Article Synopsis
  • Hepcidin, a hormone crucial for iron regulation, is shown to play a role in liver fibrosis by preventing hepatocyte apoptosis via the PERK pathway.
  • A study using CCl4-induced liver fibrosis in hepcidin knockout mice revealed that the absence of hepcidin led to more severe liver damage and increased apoptosis compared to wild-type mice.
  • Transcriptomic analysis identified that the PERK molecule is upregulated in the absence of hepcidin, suggesting its involvement in regulating cell death in liver injury, highlighting hepcidin's potential as a therapeutic target for liver fibrosis.
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Objective: This study explores alterations in renal cortical perfusion post-Early Goal-Directed Therapy (EGDT) in sepsis patients, to investigate its association with major adverse kidney events within 30 days (MAKE-30) and identify hemodynamic factors associated with renal cortical perfusion.

Methods: Sepsis patients admitted to the ICU from Jan 2022 to Jul 2023 were prospectively enrolled. Contrast-enhanced ultrasound (CEUS) assessed renal cortical perfusion post-EGDT.

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Article Synopsis
  • - This study investigates the impact of platelet transfusions on pediatric patients undergoing extracorporeal membrane oxygenation (ECMO) after cardiac surgery, focusing on minimizing risks of thrombocytopenia and bleeding.
  • - Researchers analyzed data from 11 patients who received a total of 47 platelet transfusions, assessing the effectiveness using the corrected count increment (CCI) before and 24 hours post-transfusion.
  • - Findings revealed that only 46.8% of the transfusions were effective, and patients were categorized based on their pretransfusion platelet counts to evaluate the efficacy of varying transfusion thresholds.
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Objective: To compare thulium laser enucleation of the prostate (ThuLEP) with plasma kinetic resection of the prostate (PKRP) in the treatment of BPH.

Methods: We retrospectively analyzed the medical records of 160 cases of BPH treated by ThuLEP (the observation group, n = 80) or PKRP (the control group, n = 80) in our hospital from January 2021 to December 2023. We recorded the operation time, bladder irrigation time, catheter retention time, hospitalization time, postoperative complications, and pre- and postoperative maximum urinary flow rate (Qmax), residual urine volume (PVR), prostate-specific antigen (PSA) and prostate volume, followed by comparison of the data obtained between the two groups of patients.

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Clinical Guidelines on Compression Therapy in Venous Diseases.

Ann Vasc Surg

January 2025

Department of Vascular Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address:

Article Synopsis
  • Compression therapy is gaining recognition in treating lower extremity venous diseases, but there's a lack of common understanding and standards in its application.
  • A team used the GRADE approach to assess evidence quality and made 30 recommendations for various venous diseases, focusing on both strong and moderate evidence.
  • Among the recommendations, there were 7 strong recommendations and 17 backed by high-quality evidence, underscoring the necessity for more research in compression therapy.
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Focus on oliguria during renal replacement therapy.

J Anesth

October 2024

Department of Intensive Care Unit (ICU), The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, People's Republic of China.

Oliguria is a clinical symptom characterized by decreased urine output, which can occur at any stage of acute kidney injury and also during renal replacement therapy. In some cases, oliguria may resolve with adjustment of blood purification dose or fluid management, while in others, it may suggest a need for further evaluation and intervention. It is important to determine the underlying cause of oliguria during renal replacement therapy and to develop an appropriate treatment plan.

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[Expert consensus on the application of critical care ultrasonography in invasive procedures].

Zhonghua Nei Ke Za Zhi

May 2024

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730,China.

The evolution of critical care medicine is inextricably linked to the development of critical care procedures. These procedures not only facilitate diagnosis and treatment of critically ill patients, but also provide valuable insights into disease pathophysiology. While critical care interventions offer undeniable benefits, the potential for iatrogenic complications necessitates careful consideration.

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[Reflections and prospects on standardized rounds for critical illness].

Zhonghua Nei Ke Za Zhi

May 2024

Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100041, China.

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Background: Rituximab (RTX), an anti-CD20 monoclonal antibody, has shown promise in managing neuromyelitis optica spectrum disorders (NMOSD) by depleting B cells and reducing relapses. However, there is no consensus on the optimal RTX dosing regimen, and genetic factors, such as FCGR3A-V158F polymorphism, may influence treatment outcomes. This study investigates how FCGR3A-V158F genotypes influence RTX efficacy in Chinese NMOSD patients under varying dosing regimens and aims to optimize treatment protocols.

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Prelacrimal recess approach for maxillary sinus inverted papilloma: a 15-year experience from a single center.

Eur Arch Otorhinolaryngol

September 2024

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: This large retrospective, single-center, follow-up study investigated the endoscopic prelacrimal recess approach (PLRA) for treating maxillary sinus inverted papilloma (MSIP).

Methods: Between January 2007 and November 2022, patients with MSIP treated with PLRA were enrolled. Data on clinical manifestations, imaging, and surgical procedures were collected.

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Gait is an important basic function of human beings and an integral part of life. Many mental and physical abnormalities can cause noticeable differences in a person's gait. Abnormal gait can lead to serious consequences such as falls, limited mobility and reduced life satisfaction.

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[Analysis and treatment workflow of modified seven-step approach for acute respiratory and circulatory disorders].

Zhonghua Nei Ke Za Zhi

December 2023

Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100041, China.

Acute respiratory and circulatory disorders are the most common critical syndromes, the essence of which is damage to the organs/systems of the heart and lungs. These comprise the essential manifestation of disease and injury progression to the severe stage. Its development involves the following components: individual specificity, primary disease strike, dysregulation of the host's response, and systemic disorders.

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The multiple etiological characteristics of acute kidney injury (AKI) have brought great challenges to its clinical diagnosis and treatment. Renal injury in critically ill patients always indicates hemodynamic injury. The Critical Care UltraSound Guided (CCUSG)-ABCDE protocol developed by the Chinese Critical Ultrasound Study Group (CCUSG), respectively, includes A diagnosis and risk assessment and uses B-mode ultrasound, Color doppler ultrasound, spectral Doppler ultrasound, and contrast Enhanced ultrasound to obtain the hemodynamic characteristics of the kidney so that the pathophysiological mechanism of the occurrence and progression of AKI can be captured and the prognosis of AKI can be predicted combined with other clinical information; therefore, the corresponding intervention and treatment strategies can be formulated to achieve targeted, protocolized, and individualized therapy.

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Evaluation of the accuracy of cone-beam computed tomography image segmentation of isolated tooth roots based on the dynamic threshold method.

BMC Oral Health

October 2023

Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, 95 Yong 'an Road, Xicheng District, Beijing, 100050, China.

Objective: Accurate quantification of the root surface area (RSA) plays a decisive role in the advancement of periodontal, orthodontic, and restorative treatment modalities. In this study, we aimed to develop a dynamic threshold-based computer-aided system for segmentation and calculation of the RSA of isolated teeth on cone-beam computed tomography (CBCT) and to assess the accuracy of the measured data.

Method: We selected 24 teeth to be extracted, including single-rooted and multi-rooted teeth, from 22 patients who required tooth extraction.

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Objective: To validate a single-lead electrocardiogram algorithm for identifying atrial fibrillation, atrial premature beats, ventricular premature beats, and sinus rhythm.

Methods: A total of 656 subjects aged 19 to 94 years were enrolled. Participants were simultaneously tested with a wristwatch (Huawei Watch GT2 Pro, Huawei Technologies Co.

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Objective: This study aimed to investigate the relationship between hearing impairment, depressive symptoms, and social participation in older adults.

Methods: The study used data from the China Health and Retirement Longitudinal Study (CHARLS) in 2013 and 2018, which included 3,980 samples. The analysis was conducted using cross-lagged structural equation modeling with SPSS 23.

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Objective: This study aimed to analyze the potential targets and mechanism of the Tiannanxing-shengjiang drug pair in pain treatment using network pharmacology and molecular docking technology.

Methods: The active components and target proteins of Tiannanxing-Shengjiang were obtained from the TCMSP database. The pain-related genes were acquired from the DisGeNET database.

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[Expert consensus on late stage of critical care management].

Zhonghua Nei Ke Za Zhi

May 2023

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

We wished to establish an expert consensus on late stage of critical care (CC) management. The panel comprised 13 experts in CC medicine. Each statement was assessed based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) principle.

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Objective: Radiofrequency catheter ablation (RFCA) has evolved into an effective and safe technique for the treatment of tachyarrhythmia in children. Concerns about children and involved medical staff being exposed to radiation during the procedure should not be ignored. "Fluoroscopy integrated 3D mapping", a new 3D non-fluoroscopic navigation system software (CARTO Univu Module) could reduce fluoroscopy during the procedure.

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Background: Traditional radiography angles do not adequately reveal the shape and position of the right ventricular pacing electrode.

Objective: This study aimed to explore better radiography angles with the help of cardiac computed tomography (CT).

Methods: We analyzed the cardiac CT images of consecutive outpatients from 2018 to 2019.

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Background And Aims: Collagen β(1-O) galactosyltransferase 25 domain 1 (GLT25D1) is associated with collagen production and glycosylation, and its knockout in mice results in embryonic death. However, its role in liver fibrosis remains elusive, particularly in hepatic stellate cells (HSCs), the primary collagen-producing cells associated with liver fibrogenesis. Herein, we aimed to elucidate the role of GLT25D1 in HSCs.

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Background: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by attention deficit, hyperactivity, and impulsivity. Jing-Ning Granules (JNG) is a traditional Chinese medicine (TCM) that can alleviate ADHD. Although JNG is commonly used for the effective treatment of ADHD and has obtained the national invention patent, the exact mechanism of action remains unclear.

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Solitary splenic tuberculosis: A case report.

World J Clin Cases

October 2022

Gastroenterology Department, The First Affiliated Hospital of Tsinghua University, Beijing 100016, China.

Background: Solitary splenic tuberculosis (TB) is unusual and rarely reported. Whether splenic TB is best treated surgically is still controversial. We describe a 73-year-old man with solitary splenic TB and no extrapulmonary TB.

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