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Article Synopsis
- Microvascular hyperpermeability after a burn injury causes shock and cardiovascular collapse if not treated properly.
- GM-CSF has been shown to decrease this permeability and protect microvessels, but its exact mechanism was not previously understood.
- This study found that GM-CSF enhances endothelial cell stability by inhibiting RhoA activity and preserving VE-cadherin localization, which helps prevent cell death and maintain cell connections after burn injury.