5 results match your criteria: "The First Affiliated Hospital of Navy Medical University (Changhai Hospital)[Affiliation]"
Development of a Graphene Oxide-Based Aptamer Nanoarray for Improved Neutralization and Protection Effects Against Ricin.
Pharmaceutics
November 2024
Clinical Research Unit, The First Affiliated Hospital of Navy Medical University (Changhai Hospital), 168 Changhai Road, Shanghai 200433, China.
Article Synopsis
- Ricin is highly toxic and poses a bioweapon threat, necessitating the development of effective antidotes; this study focuses on a graphene oxide-based nanotechnology called ARMAN as a potential solution.
- ARMAN is created using high-affinity aptamers targeting ricin, demonstrating improved neutralization capabilities and increased cell viability in various cell lines, as well as extending the survival of ricin-poisoned mice in vivo.
- The study indicates that ARMAN could serve as a rapid-response antidote with notable advantages in binding affinity, stability, and therapeutic efficacy, suitable for emergency use in both military and civilian contexts.
Targeting senescence with radioactive Ra/Ba SAzymes enables senolytics-unlocked One-Two punch strategy to boost anti-tumor immunotherapy.
Biomaterials
April 2025
Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Yan-chang-zhong Road, Shanghai, 200072, China; Institute of Nuclear Medicine, Tongji University School of Medicine, No. 301 Yan-chang-zhong Road, Shanghai, 200072, China. Electronic address:
Senescent cells are characterized by a persistent cessation of their cell cycle, rendering them valuable targets for anti-tumor strategies in cancer treatment. Numerous studies have explored induced senescence as a promising approach in tumor therapy. Nevertheless, these treatments often come with drawbacks, including adverse side effects and weaker senescence-inducing effects.
View Article and Find Full Text PDFAlpha-Emitter Radium-223 Induces STING-Dependent Pyroptosis to Trigger Robust Antitumor Immunity.
Small
March 2024
Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Radium-223 ( Ra) is the first-in-class alpha-emitter to mediate tumor eradication, which is commonly thought to kill tumor cells by directly cleaving double-strand DNA. However, the immunogenic characteristics and cell death modalities triggered by Ra remain unclear. Here, it is reported that the Ra irradiation induces the pro-inflammatory damage-associated molecular patterns including calreticulin, HMGB1, and HSP70, hallmarks of tumor immunogenicity.
View Article and Find Full Text PDF68 Ga-PSMA-11 PET/CT and PET/MRI in Rectal Linitis Plastica Secondary to Prostate Adenocarcinoma.
Clin Nucl Med
March 2023
Department of Nuclear Medicine, The First Affiliated Hospital of Navy Medical University (Changhai Hospital), Shanghai, China.
Primary or secondary rectal linitis plastica is rare. We describe MRI, 68 Ga-PSMA-11 PET/CT, and PET/MRI findings in a case of rectal linitis plastica secondary to prostate adenocarcinoma. In this case, the rectal linitis plastica was the first manifestation of the prostatic adenocarcinoma, and the rectum was the only metastatic site of the prostate adenocarcinoma.
View Article and Find Full Text PDFLipid-Poor Renal Angiomyolipoma Mimicking Renal Cell Carcinoma on 68 Ga-FAPI-04 PET/CT.
Clin Nucl Med
November 2022
From the Department of Nuclear Medicine, the First Affiliated Hospital of Navy Medical University (Changhai Hospital).
FAPI PET/CT findings of renal tumors have been rarely reported. We describe 68 Ga-FAPI-04 PET/CT findings in 1 case with lipid-poor renal angiomyolipoma and 1 case with high-grade clear cell renal cell carcinoma. Both tumors showed intense 68 Ga-FAPI-04 uptake.
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