The etiological role of endoplasmic reticulum stress in acute lung injury-related right ventricular dysfunction in a rat model.

This study aimed to ascertain whether endoplasmic reticulum (ER) stress participates in acute lung injury (ALI) and related right ventricular dysfunction (RVD) as well as to explore the underlying mechanisms of these conditions. A single intratracheal instillation of lipopolysaccharide (LPS) (10 mg/kg) was used to establish the RVD model. The ER stress inhibitor, 4-PBA (500 mg/kg), was administered using a gavage 2 hours before and after the LPS treatment for prevention and treatment, respectively.

Hyperplasia suppressor gene polymorphisms and essential hypertension: a case-control association study in a central Han Chinese population.

Background: (hyperplasia suppressor gene, also named ) gene polymorphisms have been studied as a candidate gene in essential hypertension, but no clear consensus has been reached in the Chinese population. To systematically explore their possible association, a case-control study was conducted in a central Chinese population.

Methods And Results: We recruited 402 EH patients and 267 normotensive (NT) control subjects.

MicroRNA-195 inhibits proliferation and metastasis in renal cell carcinoma via regulating HMGA1.

Growing evidence indicates that aberrant expression of microRNAs (miRNAs) contributes to tumorigenesis in various human malignancies. In this study we revealed that miR-195 acted as a tumor suppressor in renal cell carcinoma (RCC) through inhibition of HMGA1 expression. qRT-PCR was used to detect the miR-195 expression in RCC tissues and cell lines.

Identification of biomarkers for the transition from low-grade glioma to secondary glioblastoma by an integrated bioinformatic analysis.

Secondary glioblastoma (sGBM) is a type of glioblastoma multiforme that evolves from low-grade glioma (LGG). However, the mechanism of this transition still remains poorly understood. In this study, we used weighted gene co-expression network analysis (WGCNA) on the gene expression profiles of glioma samples from the Chinese Glioma Genome Atlas (CGGA) database to identify key genetic module related to distinguish histological characteristics.

Changed hemodynamics in acute vasoreactivity testing: prognostic predictors in chronic thromboembolic pulmonary hypertension.

Chronic thromboembolic pulmonary hypertension (CTEPH) is similar to pulmonary arterial hypertension (PAH) in its pathogenesis. Changed hemodynamic parameters in acute vasoreactivity testing (AVT) have proved to be prognostic predictors of PAH. We wanted to determine whether these changed indices also impacted the prognosis of CTEPH.

P27 deletion enhances hematopoiesis by paracrine action of IL22 secreted from bone marrow mesenchymal stem cells.

Previous studies have reported that p27 deletion stimulates the proliferation of bone marrow mesenchymal stem cells (BM-MSCs) and their differentiation into osteoblasts, it also increases bone marrow hematopoietic progenitor cells (HPCs). However, it is unknown whether the enhanced hematopoiesis induced by p27 deficiency was associated with releasing hematopoietic stem cell (HSC) and HPC supporting factors by BM-MSCs. To answer this question, we cultured the BM-MSCs from wild-type (WT) or p27 knockout (KO) mice, analyzed their proliferation, apoptosis and osteogenesis and harvested their conditioned medium (CM); We also cultured the bone marrow cells (BMCs) with normal medium or CM from WT or KO BM-MSCs and analyzed changes of HSCs and HPCs and colony forming cells (CFCs).

Early-Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study.

Background Previous studies reported that early-life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but the association with risk of cardiovascular disease (CVD) later in life remains unclear. The current study aimed to investigate whether exposure to Chinese famine in early life is associated with risk of CVD. Methods and Results We used data from REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study), which recruited a total of 259 657 community-dwelling adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012.

Superior antitumor effect of self-assembly supramolecular paclitaxel nanoparticles.

Paclitaxel (Ptx), a microtubule depolymerization inhibitor, is one of the first-line regimens in lung cancer chemotherapy. However, the poor solubility of Ptx, as well as hypersensitivity of the solvent Cremphor EL, severely limits its clinical application. Here we developed a drug-polymer conjugate of Ptx-SA-PEG, in which amphiphilic copolymers poly(ethylene glycol) (PEG) and Ptx were conjugated by succinic acid (SA).

2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary.

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials.

The clinicopathological features of metastatic tumors of the bladder: analysis of 25 cases.

Objective: To introduce the histological features and immunohistochemical results of bladder metastatic tumors, with emphasis on the points of distinction from primary bladder tumors.

Methods: A total of 25 cases were diagnosed as bladder metastatic tumors in the First Affiliated Hospital of Nanjing Medical University from January 1, 2009 to August 31, 2017. All of these were retrospectively analyzed, and immunohistochemical stainings were performed to confirm the diagnoses.

MicroRNA-940 inhibits epithelial-mesenchymal transition of glioma cells via targeting ZEB2.

MicroRNAs have been found ectopically expressed in many cancers and play essential roles in tumor EMT progress. Recent studies identified decreased miR-940 expression in glioma cells and may serve as a tumor-suppressor. However, whether miR-940 involve in glioma EMT remain poorly understood.

Characteristics of intestinal microflora involved insacral nerve stimulation affecting visceral hypersensitivity.

Objective: This study was to investigate the effect of intestinal flora-intestinal-brain on the visceral sensitivity of normal rat and visceral hypersensitivity model rats, and to explore the effect of intestinal flora-intestinal-brain axis on visceral hypersensitivity in rats.

Methods: Sixty SD male newborn rats were randomly divided into 4 groups according to the random number table: group A, group B, group C, and group D, with 15 rats in each group. 15 sterile SD newborn rats, numbered E group.

Granular cell variant of meningioma: a case report and review of the literature.

We describe a diagnostically challenging case of granular cell variant of meningioma. The tumor was observed in the temporal and parietal lobes of the right cerebrum. Microscopically, neoplastic cells with granular and eosinophilic cytoplasm were round, polygonal, or spindled with no apparent mitosis or atypia.

Hypoxia-induced EPHB2 promotes invasive potential of glioblastoma.

EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. However, the mechanisms of the EPHB2 regulatory network in glioma remain enigmatic.

Autoimmune pancreatitis masquerading as pancreatic cancer: case report of a Chinese man.

Autoimmune pancreatitis (AIP) is a type of chronic pancreatitis with an autoimmune basis, characterized by infiltrating lymphocytes and plasma cells and fibrosis. Imaging examination revealed pancreatic enlargement and irregular stenosis of the pancreatic duct, and laboratory inspection showed elevated serum IgG4 level. Effectiveness of glucocorticoids (hormone) management is a remarkable feature of this disease.

MiR-145: a potential biomarker of cancer migration and invasion.

MircoRNAs (miRNAs) are a diverse family of highly-conserved small non-coding RNAs, which range from approximately 18 to 25 nucleotides in size. They regulate gene expression transcriptionally or post-transcriptionally via binding to the 3'-untranslated region (3'-UTR) of target message RNAs (mRNAs). MiRNAs have emerged as molecular regulators that participate in physiological and pathological processes of diverse malignancies.

Associations between single nucleotide polymorphisms in miR-221, self-reported essential hypertension, and interactions between genetic and environmental factors: a multiethnic study in China.

This case-control study explored the relationship between SNPs in miR-221 and self-reported essential hypertension, as well as interactions between genetic and environmental factors, in a multiethnic Chinese cohort. A MassArray analysis was performed to genotype 462 patients with essential hypertension and 442 healthy participants. The association between four SNPs in miR-221 and essential hypertension risk was determined by investigating the differences in allelic and genotypic frequencies between case and control groups using PLINK version 1.

mutations contribute to fulvestrant resistance in ER-positive breast cancer.

p110α is an important subunit of phosphatidylinositol-3-kinases (PI3Ks) encoded by . Though PI3Ks are known as crucial regulators of cellular growth and proliferation, the function of mutations in fulvestrant resistance remains elusive. Thus, this study aimed to investigate the roles of mutations in fulvestrant resistance and tumor progression.

Resveratrol improves cardiac function by promoting M2-like polarization of macrophages in mice with myocardial infarction.

Macrophage polarization determines the transition from the inflammation phase to the inflammation resolution phase after myocardial infarction (MI). The aim of the present study was to investigate whether resveratrol (RSV) could inhibit the inflammatory mediators associated with the regulation of macrophage phenotypes and functions in MI mice. We initially discovered that RSV significantly improved cardiac function and suppressed the expression of fibrosis markers, such as collagen-I, collagen-III, and fibronectin, and pro-inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α).

MicroRNA-188 inhibits proliferation migration and invasion of prostate carcinoma by targeting at MARCKS.

Recent evidences suggested that miRNAs process key roles in the biological behaviors and the development of prostate carcinoma (PC). However, its molecular mechanism in PC is still remained largely unclear. In this study, the expression level of miR-188 and the protein expression of MARCKS were detected by RT-PCR and western blot, respectively.

4-Hydroxy estrogen metabolite, causing genomic instability by attenuating the function of spindle-assembly checkpoint, can serve as a biomarker for breast cancer.

Sex hormone metabolism is altered during mammary gland tumorigenesis, and different metabolites may have different effects on mammary epithelial cells. This study aimed to evaluate associations between urinary sexual metabolite levels and breast cancer risk among premenopausal women of Mainland China. The molecular metabolism of the cancer-related metabolites was also explored based on the clinical data.

The lncRNA-DLEU2/miR-186-5p/PDK3 axis promotes the progress of glioma cells.

Long non-coding RNAs (lncRNAs) have great value in research on tumour targeted therapy, including for glioma. In the present study, we investigated the role of the lncRNA deleted in lymphocytic leukaemia 2 (lncRNA-DLEU2) in glioma. First, we found that lncRNA-DLEU2 is highly expressed in glioma tissues and cell lines.