PM2.5 is linked to Alzheimer's syndrome and delirium: a mendelian randomization analysis.

Background: Increasing air pollution has drawn our attention to particulate matter (PM2.5), which has been shown to correlate significantly with respiratory and cardiovascular systems. However, whether PM2.

Analysis of influencing factors of hemorrhagic transformation in patients with large vessel occlusion stroke after mechanical thrombectomy.

Objective: To investigate the influencing factors of hemorrhagic transformation (HT) after mechanical thrombectomy (MT) in patients with large vessel occlusion (LVO) stroke.

Methods: From September 2018 to December 2022, 270 eligible patients with LVO who underwent MT in the First Affiliated Hospital of Nanjing medical University were selected for this retrospective study, and the patients were divided into an occurrence group and a non-occurrence group based on the immediate and 24 h postoperative head CT results. The influencing factors of postoperative HT after MT were identified using univariate and logistic regression analyses.

Ferroptosis, a new form of cell death: mechanisms, biology and role in gynecological malignant tumor.

Ferroptosis, a term coined by Dixon et al. in 2012, refers to an iron-dependent form of regulated cell death driven by an overload of lipid peroxides on cellular membranes. It is morphologically and mechanistically distinct from apoptosis and other types of regulated cell death.

4-Hydroxy estrogen metabolite, causing genomic instability by attenuating the function of spindle-assembly checkpoint, can serve as a biomarker for breast cancer.

Sex hormone metabolism is altered during mammary gland tumorigenesis, and different metabolites may have different effects on mammary epithelial cells. This study aimed to evaluate associations between urinary sexual metabolite levels and breast cancer risk among premenopausal women of Mainland China. The molecular metabolism of the cancer-related metabolites was also explored based on the clinical data.

MicroRNA-485-5p attenuates cell proliferation in glioma by directly targeting paired box 3.

MicroRNA-485-5p (miR-485-5p) has been reported to be involved in the development and progression of human cancers; however, its role in glioma remains unclear. In the present study, we found that miR-485-5p was significantly down-regulated in both glioma tissues and cell lines. Functional experiments indicated that enhanced expression of miR-485-5p attenuated glioma cell proliferation in vitro and in vivo, and induced glioma cells cycle arrest in G1.

The malignancy of miR-18a in human glioblastoma via directly targeting CBX7.

Aberrant levels of microRNAs (miRNAs) are linked to tumorigenesis and tumor progression. Here we analyzed the expression of microRNA 18a in glioblastoma multiforme (GBM) within groups of coexpressed groups of genes through analysis of expression profiling databases and clinical tissues. Cell proliferation and flow cytometry experiments were performed to determine the roles of miR-18a in the proliferation of glioblastoma cells in vitro.