3 results match your criteria: "The First Affiliated Hospital of Nanchang University No. 17[Affiliation]"
Clinical retrospective study on the expression of the PD-L1 molecule in sporadic colorectal cancer and its correlation with K-ras gene mutations in Chinese patients.
Am J Transl Res
June 2021
Department of Pathology, The First Affiliated Hospital of Nanchang University No. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi, China.
Article Synopsis
- The study investigates PD-L1 expression and K-ras gene status in colorectal cancer tissues, aiming to find correlations with clinical features.
- PD-L1 was found to be highly expressed in tumors, with increased levels linked to lymph node metastasis and advanced TNM stages, as well as lower survival rates.
- The K-ras mutation rate was 35.6%, with a notable association between PD-L1 expression levels and K-ras mutations, suggesting that K-ras status may influence PD-L1 expression in colorectal cancer.
IL-1β promotes cervical cancer through activating NF-κB/CCL-2.
Int J Clin Exp Pathol
April 2021
Department of Geriatrics, The First Affiliated Hospital of Nanchang University No. 17, Yong Wai Zheng Road, Nangchang 330006, China.
Cervical cancer is a malignancy with high morbidity and mortality among women. Interleukin (IL)-1β, chemokine (C-C motif) ligand 2 (CCL-2), and activation of NF-κB have been proven to be closely related to the progression of various tumors. However, their role in cervical cancer remains unclear.
View Article and Find Full Text PDFPPARγ induces the paroxysm of endometriosis by regulating the transcription of MAT2A gene.
Am J Transl Res
March 2021
The First Affiliated Hospital of Nanchang University No. 17 Yongwaizheng Street, Donghu District, Nanchang, Jiangxi, People's Republic of China.
Objective: To investigate the molecular mechanism of PPARγ impacting the paroxysm of endometriosis.
Methods: Immunohistochemistry, qRT-PCR and Western Blot were used to determine the expression level of PPARγ and MAT2A in Eu, Ec and normal endometrial tissue (control). ESC and NSC were separately isolated.