[A review on the application of image fusion technology in prostate cancer radiotherapy based on gold fiducial biomarker].

Image fusion technology had been widely applied in image guided radiotherapy (IGRT) for prostate cancer (PCa) based on the gold fiducial mark (GFM). Image fusion technology included the fusion of CT image, magnetic resonance image, and ultrasound image internally or externally. The application of image fusion technology had improved the identification accuracy of GFM and was helpful for the plan design of PCa radiotherapy.

The Role of High Mobility Group Box B-1 in the Prognosis of Colorectal Cancer Based on the Changes in the Intestinal Mucosal Barrier.

To investigate the expression of high mobility group box B-1 (HMGB-1) in patients with colorectal cancer (CRC) and its association with clinicopathological features and prognosis in colorectal carcinoma by combining bioinformatics and clinical data analysis, and to clarify the role of HMGB-1. To examine whether HMGB-1 expression is related to the damage of the intestinal mucosal barrier, and then explore the potential HMGB-1-dependent mechanisms affecting the progression of CRC. CRC datasets of GSE12945, GSE17536, and GSE17537 from the public gene chip database were screened and downloaded.

Fraxetin protects rat brains from the cerebral stroke promoting angiogenesis and activating PI3K/Akt pathway.

Objective: Fraxetin has antioxidant, anti-inflammation and neuroprotective functions, however, its role in ischemic stroke is still vague. Herein, this study delves into the underlying mechanism.

Methods: Ischemia and reperfusion operation were performed to establish the cerebral stroke rat models.

Contrasting dorsal caudate functional connectivity patterns between frontal and temporal cortex with BMI increase: link to cognitive flexibility.

Background: Obesity is associated with brain intrinsic functional reorganization. However, little is known about the BMI-related interhemispheric functional connectivity (IHFC) alterations, and their link with executive function in young healthy adults.

Methods: We examined voxel-mirrored homotopic connectivity (VMHC) patterns in 417 young adults from the Human Connectome Project.

Prognostic Impact of PD-1 and Tim-3 Expression in Tumor Tissue in Stage I-III Colorectal Cancer.

Background: Programmed cell death receptor 1 (PD-1) and T cell immunoglobulin mucin-3 (Tim-3) are considered as important immunosuppressive molecules and play an important role in tumor immune escape and cancer progression. However, it remains unclear whether PD-1 and Tim-3 are coexpressed in stage I-III colorectal cancer (CRC) and how they impact on the prognosis of the disease.

Materials And Methods: A total of two cohorts with 451 patients who underwent surgery for stage I-III CRC treatment were enrolled in the study.