7,714 results match your criteria: "The First Affiliated Hospital of Anhui Medical University[Affiliation]"
BMC Geriatr
December 2024
Geriatric Endocrinology, Department of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Shushan District, Hefei City, Anhui Province, China.
Objectives: To investigate the correlation between blood glucose fluctuation parameters and other clinical data with chronic pain in older patients ( ≧ 60 years) with type 2 diabetes mellitus (T2DM), as well as evaluating the predictive value of risk of these parameters for chronic pain.
Methods: Clinical data were collected from 60 older patients with T2DM undergoing chronic pain who were hospitalized in the Department of Geriatric Endocrinology at the First Affiliated Hospital of Anhui Medical University. Pain scores using the numeric rating scale (NRS) were administered to all study participants by a dedicated person.
Int J Cardiol
December 2024
Central China Fuwai Hospital, Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address:
Background: The vagal response (VR) is unavoidable during pulmonary vein isolation (PVI) for atrial fibrillation (AF). In this study, we aimed to investigate the incidence, risk factors, and clinical outcomes of VR during PVI initiated from the right superior pulmonary vein (RSPV).
Methods: Patients with AF were consecutively enrolled.
FEBS Open Bio
December 2024
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hepatocellular carcinoma remains a significant threat to human health. Recent studies have found that the intake of cellular cholesterol contributes to the development and progression of hepatocellular carcinoma, although the exact mechanisms remain unclear. Our analysis of transcriptomic and proteomic databases has identified increased mRNA and protein expression levels of NPC1, a cholesterol intracellular transporter protein, in hepatocellular carcinoma tissues.
View Article and Find Full Text PDFLeukemia
December 2024
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, Guangdong, China.
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy and the most common form of non-Hodgkin lymphoma (NHL) that occurs worldwide. To discover risk factors and pathogenesis of DLBCL, we performed the largest GWAS of DLBCL to date in samples of East Asian ancestry, consisting of 2,888 patients with DLBCL and 12,458 controls. The meta-analysis identified three novel loci, rs2233434 on 6p21.
View Article and Find Full Text PDFInt Immunopharmacol
December 2024
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Institute of Urology, Anhui Medical University, Hefei, China; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, China. Electronic address:
Kidney stones consist largely of calcium oxalate (CaOx), and induce inflammation and damage to renal tubular epithelial (RTE) cells, leading to CaOx nephrocalcinosis. Sirtuin 6 (SIRT6), a sirtuin family member, is an NAD-dependent deacetylase that has been associated with cell damage and inflammation in various diseases. This study evaluated the efficacy of the novel SIRT6 allosteric agonist MDL-800 in treating CaOx nephrocalcinosis.
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs, No 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address:
The vaginal microbiota is proposed to be associated with reproductive health. Exposure to metals during pregnancy is a risk factor for premature rupture of membranes (PROM). PROM can lead to serious maternal complications, thus, identifying the cause and therapeutic targets for it is crucial.
View Article and Find Full Text PDFJ Mater Chem B
December 2024
Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Acute lung injury (ALI) is a critical clinical disease caused by direct factors (inhalation injury, gastroesophageal reflux, ) or indirect factors (including infection, sepsis, burn, shock, trauma, acute pancreatitis, fat embolism, drug overdose, ). ALI is characterized mainly by diffuse interstitial and alveolar edema caused by an uncontrolled inflammatory response and damage to the alveoli-capillary barrier and has very high morbidity and mortality rates. Currently, there is no effective treatment strategy other than mechanical ventilation, fluid management or other supportive treatments.
View Article and Find Full Text PDFBackground: Although some studies suggest that sleep deprivation may affect ejaculation regulation, related research is limited, and the mechanisms remain unclear.
Aim: This study aimed to explore whether sleep deprivation influences ejaculation regulation through amyloid-beta and to investigate its potential mechanisms.
Materials And Methods: Normal ejaculating rats were randomly distributed into three separate groups for the study, and treated with sleep deprivation combined with saline gavage, sleep deprivation combined with sodium butyrate gavage, and control with saline gavage.
Histol Histopathol
December 2024
Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, PR China.
Background: High levels of histocompatibility minor 13 (HM13) have been related to the progression of several cancers. Here, we investigated the function of HM13 in colorectal cancer (CRC).
Methods: HM13 expression, clinicopathology analysis, and its influence on survival were analyzed in multiple public databases (TCGA, TIMER2.
Endoscopy
January 2025
Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
J Autoimmun
December 2024
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Graduate School of Peking Union Medical College, Nanjing, China; Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address:
Chimeric antigen receptor T (CAR-T) cells are genetically engineered T cells expressing transmembrane chimeric antigen receptors with specific targeting abilities. As an emerging immunotherapy, the use of CAR-T cells has made significant breakthroughs in cancer treatment, particularly for hematological malignancies. The success of CAR-T cell therapy in blood cancers highlights its potential for other conditions in which the clearance of pathological cells is therapeutic, such as liver diseases, infectious diseases, heart failure, and diabetes.
View Article and Find Full Text PDFPhys Med Biol
December 2024
School of Nuclear Science and Technology, University of Science and Technology of China, No.96, JinZhai Road Baohe District, Hefei, Anhui, China, Hefei, 230026, CHINA.
The primary purpose of this work is to demonstrate the feasibility of a deep convolutional neural network (dCNN) based algorithm that uses two-dimensional (2D) EPID images and CT images as input to reconstruct 3D dose distributions inside the patient. Approach: To generalize dCNN training and testing data, geometric and materials models of a VitalBeam accelerator treatment head and a corresponding EPID imager were constructed in detail in the GPU-accelerated Monte Carlo dose computing software, ARCHER. The EPID imager pixel spatial resolution ranging from 1.
View Article and Find Full Text PDFPLoS Pathog
December 2024
School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui Province, P.R. China.
Schistosomiasis is characterized by egg-induced hepatic granulomas and subsequent fibrosis. Monocyte-derived macrophages play critical and plastic roles in the progression and regression of liver fibrosis, adopting different polarization phenotypes. Mammalian STE20-like protein kinase 1 (MST1), a serine/threonine kinase, has been established to act as a negative regulator of macrophage-associated inflammation.
View Article and Find Full Text PDFEur Radiol
December 2024
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Objective: The incidence of vertebral fragile fractures peaked among the elderly population, and identifying individuals at high risk of vertebral fractures and promptly instituting preventions are of critical importance. This study aims to determine the efficacy and values of Hounsfield unit (HU) values, vertebral bone quality (VBQ) scores, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA), and quantitative computed tomography (QCT) to discriminate between patients with and without vertebral fractures.
Methods: A thorough search was conducted across PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, and Wan Fang Database to identify potential studies that met the eligibility criteria.
Int J Gen Med
December 2024
The First Affiliated Hospital of Anhui Medical University, Department of Cardiovascular Surgery, HeFei, People's Republic of China.
Objective: To analyze the relationship between the cardiopulmonary function and prognosis of patients with coronary heart disease after percutaneous coronary intervention (PCI).
Methods: A total of 153 patients with coronary heart disease who underwent PCI from January 2018 to April 2020 were enrolled in this study. Through careful assessment, cardiopulmonary exercise test (CPX) was performed 5 to 7 days after PCI.
Front Immunol
December 2024
Huayao Kangming Biopharmaceutical Co., Ltd, Shenzhen, China.
Oncolytic viruses have emerged as a highly promising modality for cancer treatment due to their ability to replicate specifically within tumors, carry therapeutic genes, and modulate the immunosuppressive tumor microenvironment through various mechanisms. Additionally, they show potential synergy with immune checkpoint inhibitors. A study report indicates that from 2000 to 2020, 49.
View Article and Find Full Text PDFZhonghua Wei Zhong Bing Ji Jiu Yi Xue
November 2024
Department of Intensive Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China. Corresponding author: Shao Min, Email:
Objective: To construct a nomogram prediction model for 28-day mortality in septic shock patients based on routine laboratory data mining and verify its predictive value.
Methods: The clinical data of patients with septic shock admitted to Anhui Medical University Affiliated Fuyang Hospital from January 2018 to November 2023 were retrospectively analyzed. The patients were randomly divided into training set and validation set according to the ratio of 8 : 2.
BMC Public Health
December 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
December 2024
Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei Anhui, 230032, P. R. China.
Objective: A prospective study was conducted to investigate the feasibility and effectiveness of three-dimensional printed guide plates assisted hip arthroscopy in the treatment of Cam-type femoroacetabular impingement (FAI).
Methods: The clinical data of 25 patients with Cam-type FAI who met the selection criteria between December 2016 and September 2022 were collected. There were 13 males and 12 females with an average age of 42 years (range, 19-66 years).
Gastrointest Endosc
December 2024
Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, The Key Laboratory of Digestive Diseases of Anhui Province, Hefei, Anhui Province, China. Electronic address:
Background And Aims: Acute obstructive suppurative pancreatic ductitis (AOSPD) is a rare condition with limited diagnostic and treatment information. This study aims to expand understanding by analyzing the clinical characteristics and management of AOSPD.
Methods: We analyzed 81 AOSPD cases (1993-2024) from the literature and 1 case from the First Affiliated Hospital of Anhui Medical University.
Arch Toxicol
December 2024
Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are two major chronic liver diseases worldwide. The triggers for fatty liver can be derived from external sources such as adipose tissue, the gut, personal diet, and genetics, or internal sources, including immune cell responses, lipotoxicity, hepatocyte death, mitochondrial dysfunction, and extracellular vesicles. However, their pathogenesis varies to some extent.
View Article and Find Full Text PDFPostgrad Med J
December 2024
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China.
Background: Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) are on the rise. While there is evidence of a link between the two diseases, the pathophysiological mechanisms they share are not fully understood.
Methods: In this study, the co-expressed genes of COPD and T2DM in Gene Expression Omnibus database were identified by bioinformatics method, and the functional enrichment analysis was performed.
Front Oncol
December 2024
Department of Thoracic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Introduction: We used habitat radiomics as an innovative tumor biomarker to predict the outcome of neoadjuvant therapy for esophageal cancer.
Methods: This was a two-center retrospective clinical study in which pretreatment CT scans of 112 patients with esophageal cancer treated with neoadjuvant chemoimmunotherapy and surgery between November 2020 and July 2023 were retrospectively collected from two institutions. For training (n = 85) and external testing (n = 27), patients from both institutions were allocated.
Signal Transduct Target Ther
December 2024
Department of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
The randomized phase 3 CHART trial (NCT03520478) revealed that rezvilutamide (REZ) plus androgen deprivation therapy (ADT) in high-volume, metastatic, hormone-sensitive prostate cancer (mHSPC) significantly enhanced radiographic progression-free and overall survival than bicalutamide (BIC)-ADT. Accordingly, we examined patient-reported outcomes (PROs) results, which were exploratory endpoints in the CHART trial. The patients were randomly allocated to receive REZ-ADT or BIC-ADT in a 1:1 ratio.
View Article and Find Full Text PDFAcad Radiol
December 2024
Department of Ultrasound, The first affiliated hospital of Anhui Medical University, Hefei, Anhui 230022, China (X.Q., X.L., Q.L., L.X., C.Z.). Electronic address:
Rationale And Objectives: To develop an interpretable deep learning (XDL) model based on superb microvascular imaging (SMI) for the noninvasive diagnosis of the degree of interstitial fibrosis (IF) in chronic kidney disease (CKD).
Methods: We included CKD patients who underwent renal biopsy, two-dimensional ultrasound, and SMI examinations between May 2022 and October 2023. Based on the pathological IF score, they were divided into two groups: minimal-mild IF (≤25%) and moderate-severe IF (>25%).