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We previously showed that Adh1p participates in fluconazole (FLC) resistance in Candida albicans through a mechanism that may involve efflux pumps. We also found that the concomitant use of tetrandrine (TET) and FLC provided a synergistic action against C. albicans and that the mechanism of action could be related to inhibition of a drug efflux system.
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- Tetrandrine (TET) can reverse fluconazole resistance in Candida albicans by affecting specific drug resistance genes and energy metabolism.
- The study measured expression levels of resistance genes and ATP levels in both fluconazole-sensitive and resistant strains treated with TET and fluconazole (FLC).
- Results showed that TET treatment altered expressions of resistance genes (CDR1, CDR2, MDR1, FLU1, ERG11) and reduced intracellular ATP in both sensitive and resistant strains, indicating a potential mechanism for overcoming drug resistance.