Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome.

Introduction: This article presents the results of an international, multicenter, randomized, double-masked, placebo-controlled clinical study of Visomitin (Mitotech LLC, Moscow, Russian Federation) eye drops in patients with dry eye syndrome (DES). Visomitin is the first registered (in Russia) drug with a mitochondria-targeted antioxidant (SkQ1) as the active ingredient.

Methods: In this multicenter (10 sites) study of 240 subjects with DES, study drug (Visomitin or placebo) was self-administered three times daily (TID) for 6 weeks, followed by a 6-week follow-up period.

Intravitreal ranibizumab for the treatment of choroidal neovascularizations associated with pathologic myopia: a prospective study.

Purpose: It was the aim of this study to determine the efficacy of intravitreal ranibizumab as treatment of choroidal neovascularizations associated with pathologic myopia.

Materials And Methods: In an uncontrolled, prospective time series cohort study, 65 eyes of 64 consecutive patients with choroidal neovascularization associated with pathologic myopia were treated with intravitreal ranibizumab and observed over 12 months. The change in best-corrected visual acuity (BCVA) at 6 and 12 months served as primary end point.

High-frequency electric welding: a novel method for improved immediate chorioretinal adhesion in vitreoretinal surgery.

Purpose: To evaluate high-frequency electric welding (HFEW) as a novel technique for retinopexy with improved immediate chorioretinal adhesion

Methods: In a prospective, randomized, experimental study, we examined 104 eyes of 52 rabbits randomly assigned to either standard 810 nm endolaser retinopexy, alternating current 14-16 V or 18-20 V HFEW retinopexy. A full-thickness fragment of eye wall tissue containing the retinopexy was isolated 1 h, 3 days, 1 week, or 1 month respectively after the intervention, and fixed to an analytical electronic scale. A nylon suture passed through the retina was elevated by a biomechanical force elongation tester.

Forty-five years of keratoprosthesis study and application at the Filatov Institute: a retrospective analysis of 1 060 cases.

Aim: To present results of the keratoprosthesis method used at The Filatov Institute of Eye Diseases and Tissue Therapy.

Methods: A retrospective case series analysis was used to describe the development of new types of keratoprostheses and methods of implantation as well as different ways of leukoma strengthening.

Results: Keratoprosthesis was performed in 1 060 eyes of 1 040 patients with leukomas of different etiology: burns, 725 eyes (68.

Amniotic membrane transplantation in treatment of persistent corneal ulceration after severe chemical and thermal eye injuries.

Purpose: To analyze results of amniotic membrane transplantation (AMT) in treatment of corneal ulceration after severe chemical and thermal injuries.

Methods: Analysis of 55 AMT in 53 patients (53 eyes) with corneal ulceration and limbal deficiency 180-360° of the limbus after grade 4-6 (Dua classification, 2001) chemical and thermal injuries was performed. Mean terms of the operation were 46.

Collagen-based bioengineered substitutes of donor corneal allograft implantation: assessment and hypotheses.

To fabricate donor corneal substitutes based on carbodiimide cross-linked porcine collagen, to study their in vitro and in vivo properties, and to elaborate new implantation techniques for the donor corneal collagen-based substitutes, this study had been performed. Bioengineered substitutes of corneal stroma (BSCS) were fabricated by cross-linking porcine type I collagen with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide and N-hydroxysuccinimide, as previously described. Their refractive indices were measured using an Abbe refractometer.

Serous pigment epithelium detachment associated with age-related macular degeneration: a possible treatment approach.

To evaluate the effects of intravitreal triamcinolone acetonide (TA) as a monotherapy of serous Pigment Epithelial Detachment (PED) associated with AMD (Age-Related Macular Degeneration), this study has been performed. Seventeen patients (19 eyes) with serous PED associated with AMD were observed. All patients received 0.

Treatment of post-burn persistent corneal ulcers with excimer laser phototherapeutic keratectomy. Prospective clinical trial.

Purpose: To evaluate efficacy of excimer laser phototherapeutic keratectomy (PTK) i n treatment of patients with post-burn persistent corneal ulcers.

Material And Methods: Study design--nonrandomized trial with a "historic" control group. 54 eyes (53 patient) with central superficial post-burn corneal ulcers that were formed in different time frame (18-104 days) after grade IV burns were included into the study.

Digital imaging of the fundus with long-wave illumination.

Purpose: To increase the quality, diagnostic value and use of non-invasive fundus examination with transscleral or transpalpebral long-wave (red and near infrared) illumination.

Material And Methods: For fundus visualization we used red light diode sources at 660 nm and near infrared light diode sources at 810, 940 nm. Light radiation from diode sources penetrates into the globe through eyelid skin and sclera.

Combined surgical method of orbital and periorbital hemangioma treatment in infants.

Purpose: To analyze the results of application of combined surgical treatment in different forms of hemangioma in infants.

Materials And Methods: One hundred seventy-four children with different forms of orbital and periorbital hemangiomas aged 1-16 months (mean age 5.2 + 1.

The influence of the calcium channel blocker verapamil on experimental glaucoma.

Purpose: To study the influence of the calcium channel blocker verapamil on the development of glaucoma in the adrenalin-induced experimental model of glaucoma.

Methods: In the experimental model, glaucoma was induced in albino rabbits by repeated injections of small doses of adrenalin. The criteria for experimental glaucoma were (1) increased IOP, (2) decreased outflow and (3) decreased blood supply to the eye.