198 results match your criteria: "The Fifth People's Hospital of Suzhou[Affiliation]"

Multiple functional tailored materials have shown great potential for both pollutant degradation and freshwater recovery. In this study, we synthesized densely distributed Co onto carbon-layer-coated Ni/AlO hydrangea composites (Ni/AlO@Co) the polymerization of dopamine under a controlled graphitized process. The characterization results revealed that Ni/AlO@Co, with abundant exposed bimetallic Co-Ni species on the surface of AlO, could afford accessible catalytic sites for persulphate activation and subsequent pollutant degradation.

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This study was intended to investigate the role of DYNLL1 in lung adenocarcinoma (LUAD) and reveal the relevant molecular mechanism. To this end, we manipulated the expression of DYNLL1 and PRKN with shRNA and/or overexpression to assess their effects on A549 cell phenotypes including cell proliferation, cycle arrest and apoptosis using CCK-8 assay, EdU staining, colony formation assay, flow cytometry, TUNEL and western blot. DYNLL1 is a carcinogenic factor in LUAD since it is highly expressed and DYNLL1 upregulation is associated with the low overall survival rate of LUAD patients.

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K. pneumoniae ghosts serve as a novel vaccine formulation to enhance immune responses of A. baumannii subunit vaccine in mice.

Microb Pathog

December 2024

Medical College, Yangzhou University/Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Yangzhou, 225009, China; Jiangsu Key Laboratory of Zoonosis/ Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, 225009, China. Electronic address:

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Objective: This study aimed to assess the efficacy of innovative Chemiluminescence Immunoassay (CLIA) in testing Cryptococcal Antigen (CrAg) across two medical centers, employing the FDA-approved CrAg Lateral Flow Assay (LFA) by IMMY as a reference standard.

Methods: The study encompassed patients diagnosed with cryptococcosis at West China Hospital of Sichuan University (HX) between July 2022 and May 2023, and Suzhou Fifth People's Hospital (SZ) from September 2020 to September 2023. All specimens underwent simultaneous detection using the LFA (IMMY, Norman, USA) and CLIA (Chuanglan, Suzhou, China).

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Introduction: Mitochondrial membrane potential (MMP) and mitochondrial mass (MM) affect mitochondrial function and lymphocyte activation, but few studies on HBV infection exist. This study aimed to investigate the regulatory mechanism of mitochondrial dysfunction during HBV infection and its clinical significance by analyzing the alterations of MM and MMP in peripheral blood immune cells.

Methods: The study enrolled 90 participants, including healthy volunteers(HC) and patients with HBV infection, HBV patients were divided into chronic hepatitis B patients (CHB) and liver cirrhosis (LC) according to the study, and CHB was also divided into an inflammation group and a non-inflammation group.

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To detect the expression levels of hypoxia inducible factor-1alpha (HIF-1α) and aristaless-like homeobox 1 (ALX1) in non-small cell lung cancer and analyze the relationship between CT spectral quantitative parameters and immunohistochemical markers, in order to evaluate the biological characteristics of lung cancer by spectral CT. Spectral CT data and paraffin masses of 50 adult patients with lung cancer were collected. CT quantitative parameters including the slope of spectral curve, effective atomic number and iodine concentration in enhanced phases were acquired.

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Trends and Hospitalization Outcomes of Tetanus Cases: A Multicenter Retrospective Study in Suzhou, 2013-2023.

Risk Manag Healthc Policy

November 2024

Department of Epidemiology, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 210000, People's Republic of China.

Objective: To investigate the epidemiology, and hospitalization of tetanus in Suzhou, Jiangsu Province, China, focusing on the severity of the disease, treatment, outcomes and hospitalization costs, and to explore the risk factors for severe tetanus.

Methods: This retrospective, multicenter observational study analyzed tetanus patients admitted to various medical institutions between 2013 and 2023. Patients were classified into two groups as severe or non-severe, using the Ablett classification.

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Application of γδ T cells with different memory phenotypes in clinical diagnosis of active pulmonary tuberculosis.

Microb Pathog

January 2025

The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, SuZhou, China; Key Laboratory of Infection and Immunity of Suzhou City, The Fifth People's Hospital of Suzhou, Suzhou, China. Electronic address:

Objective: To investigate the application and clinical significance of different memory phenotypes of γδ T-cell subsets in the clinical diagnosis of pulmonary tuberculosis.

Methods: In total, 42 patients with tuberculosis (TB) according to the diagnostic criteria for tuberculosis (WS288-2017) who were treated at the Infectious Diseases Hospital affiliated with Soochow University from February 2023 to July 2023 were enrolled. Additionally, 16 patients with latent TB infection (LTBI) and 20 healthy controls (HCs) were included.

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Predictors of early and interim culture un-conversion in multidrug-resistant/rifampicin-resistant tuberculosis: a retrospective multi-center cohort study in China.

Antimicrob Resist Infect Control

October 2024

Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing, China.

Article Synopsis
  • The study evaluated factors predicting early and interim culture conversion in patients with multidrug-resistant tuberculosis (MDR/RR-TB) in China from May 2018 to January 2022.
  • A total of 813 patients were analyzed, revealing that 44.5% converted within 2 months and 79.8% within 6 months, with certain conditions like smoking and previous treatment influencing results.
  • Factors such as being AFB smear positive, having lung cavities, and bilateral disease increased the risk of culture un-conversion, while treatment regimens containing bedaquiline were found to be beneficial.
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  • This study examines the controversial use of sodium bicarbonate for treating metabolic acidosis, focusing on identifying patient types that may benefit from the therapy.
  • Researchers analyzed a large database of patients with metabolic acidosis, finding that baseline chloride and anion gap levels influenced in-hospital mortality and treatment outcomes for sodium bicarbonate.
  • The results suggest that patients with hyperchloremic metabolic acidosis might benefit from sodium bicarbonate, but more rigorous studies are needed to confirm these findings.
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Article Synopsis
  • Pulmonary tuberculosis (PTB) is a serious infectious disease, and understanding the immune response to it could aid in developing treatments for drug-resistant cases, particularly by focusing on regulatory T cells (Tregs) which suppress immune responses to the bacteria.
  • The study used flow cytometry to analyze Treg frequency and the expression of key immune molecules (BTLA, HVEM, PD-L1, PD-1) in PTB patients compared to healthy controls, finding an increased presence of Tregs in patients.
  • Interestingly, while BTLA and HVEM levels decreased on Tregs in PTB patients, these changes suggested a complex interaction that may enhance Treg activation, with mechanisms behind this needing further investigation.
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Cepharanthine attenuates pulmonary fibrosis via modulating macrophage M2 polarization.

BMC Pulm Med

September 2024

Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.

Article Synopsis
  • Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by abnormal tissue growth, and current treatments are inadequate, prompting the search for better therapies like the natural compound Cepharanthine (CEP).
  • In experiments on mice, CEP treatment significantly reduced fibrosis symptoms and markers, showing its ability to combat inflammation and lung tissue scarring.
  • The study concluded that CEP may be effective in treating pulmonary fibrosis by inhibiting key factors like fibroblast activation and promoting a type of immune response (macrophage M2 polarization).
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[Three cases of occupational chronic chloropropene poisoning].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

August 2024

Occupational Disease Department, The Affiliated Infectious Diseases Hospital of Soochow University, The Fifth People's Hospital of Suzhou, Suzhou 215000, China.

Chronic chloropropene poisoning is a disease mainly caused by peripheral nerve damage due to close contact with chloropropene in industrial production, its clinical manifestations include varying degrees of sensory, motor, or tendon reflex disorders in the distal limbs, and neuromyography can show neurogenic damage. This article analyzed and summarized the clinical characteristics, diagnosis and treatment methods of three patients with occupational chronic chloropropene poisoning, in order to enhance the clinical understanding of occupational chronic chloropropene poisoning and provide reference for clinical diagnosis and treatment.

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This article reports a case of mediastinal lymph node tuberculosis with no obvious symptoms and a concealed focus. This patient, a 33-year-old male, suffered from pain behind the sternum after eating. He underwent three gastroscopic examinations and two fine needle punctures guided by ultrasound gastroscopy but was not diagnosed.

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The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation of new blood vessels, and the death of cancer cells.

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Klebsiella pneumoniae increases invasion in intestinal epithelial cells by disrupting the cytoskeleton.

Acta Microbiol Immunol Hung

September 2024

5Department of Clinical Laboratory, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.

Klebsiella pneumoniae is an opportunistic pathogen and it can cause human mucosal lesions through the intestine, leading to bacteremia and abscess formation in liver and spleen. Previous studies have shown that K. pneumoniae can enter or cross cells through the intestinal epithelium, but the mechanism is unknown.

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Background: Hepatocellular carcinoma (HCC) ranks sixth globally in cancer incidence and third in mortality rates. Unfortunately, over 70% of HCC patients forego the opportunity for curative surgery or liver transplantation due to inadequate physical examinations, poor physical condition, and limited organ availability upon diagnosis. Clinical guidelines endorse transarterial chemoembolization (TACE) as the frontline treatment for intermediate to advanced-stage HCC.

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To explore the characteristics of adverse drug reactions during the 24-week therapy with delamanid-containing regimen for patients with multidrug-resistant and rifampicin-resistant pulmonary tuberculosis (MDR/RR-PTB). The prospective multicenter study was conducted from June 2020 to June 2023. A total of 608 eligible patients with MDR/RR-PTB were enrolled in 26 tuberculosis medical institutions in China including 364 males and 79 females, aged 39.

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Hepatitis B virus (HBV) damages liver cells through abnormal immune responses. Mitochondrial metabolism is necessary for effector functions of white blood cells (WBCs). The aim was to investigate the altered counts and mitochondrial mass (MM) of WBCs by two novel indicators of mitochondrial mass, MM and percentage of low mitochondrial membrane potential, MMP%, due to chronic HBV infection.

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First report of solitary cavitation nodules in the lungs with Mycobacterium canariasense.

J Infect Dev Ctries

May 2024

The Affiliated Infectious Diseases Hospital of Soochow University, The Fifth People's Hospital of Suzhou, Suzhou 215000, Jiangsu, China.

Article Synopsis
  • Mycobacterium canariasense is a rare and rapidly growing nontuberculous mycobacterium infection.
  • A case study reports on a 36-year-old man with a lung infection caused by this bacterium, diagnosed using advanced metagenomic sequencing of a bronchoalveolar lavage sample.
  • Successful treatment was achieved with levofloxacin and amikacin, highlighting the need for more established clinical guidelines for this infection.
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Background: Hepatocellular carcinoma (HCC) has high morbidity and mortality worldwide. Excision repair cross-complement 3 (ERCC3), a key functional gene in the nucleotide excision repair (NER) pathway, is commonly mutated or overexpressed in cancers and is thought to be a key gene contributing to the development of HCC. The characteristics of immune cell infiltration in the global tumor microenvironment (TME) mediated by ERCC3 and its related key genes in HCC are still unclear.

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Background And Aims: The application of antifibrotic drugs to treat patients with chronic liver diseases who are receiving antiviral therapies for hepatocellular carcinoma (HCC) has not been established. Here, we aimed to assess the impact of the Traditional Chinese Medicine Fuzheng Huayu (FZHY) on the occurrence of HCC in patients with hepatitis B virus-related compensated cirrhosis receiving the antiviral drug entecavir (ETV).

Methods: A multicenter retrospective cohort study was performed.

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Misdiagnosis Diagnosis of Pneumocystis Pneumonia as Chemical Pneumonitis.

Infect Drug Resist

May 2024

Department of Occupational Disease, The Fifth People's Hospital of Suzhou, Jiangsu, 215100, People's Republic of China.

Background: Auxiliaries, a mixed chemicals, for printing and dyeing characterized by their diverse range and complex chemical compositions are commonly utilized in the textile industry. These chemicals can lead to environmental contamination and pose health risks to humans.

Case Description: A 29-year-old man who worked in a printing and dyeing factory in Suzhou, China, reported having tightness in his chest and coughing.

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