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Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis.
Exp Ther Med
November 2019
Department of Hepatobiliary Surgery, Taizhou People's Hospital, The Fifth Affiliated Hospital of Nantong University Medical School, Taizhou, Jiangsu 225300, P.R. China.
Cellular senescence and natural killer (NK) cells play an important role in liver diseases. Chemokines, a component of the senescence-associated secretory phenotype, can recruit NK cells and are involved in the development of various liver diseases. The effect of the C-X-C motif chemokine ligand (CXCL)-9, -10, -11/C-X-C motif chemokine receptor (CXCR)3 axis in senescent hepatocytes remains unknown.
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