5 results match your criteria: "The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University[Affiliation]"
ACUTE KIDNEY INJURY FOLLOWING ACUTE CHOLANGITIS: A RISK MULTIPLIER FOR ADVERSE OUTCOMES AND HEALTHCARE UTILIZATION.
Shock
February 2025
Department of Critical Care Medicine, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University, Zhuhai, People's Republic of China.
Article Synopsis
- Acute kidney injury (AKI) is a serious complication that commonly occurs in patients with acute cholangitis (AC), with a notable incidence of about 24.06%.
- The study analyzed data from 2010 to 2018 to determine trends and outcomes associated with AKI in AC patients, finding that AKI leads to more complications, longer hospital stays, and higher mortality rates.
- Key risk factors for developing AKI include advanced age, specific health conditions, and hospital characteristics, while factors like female sex and private insurance may help reduce the risk of AKI in these patients.
Molecular mechanism of circHIPK3 in mitochondrial function in septic acute kidney injury.
Environ Toxicol
May 2024
Department of Critical Care Medicine, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University, Zhuhai, People's Republic of China.
Cell senescence, glycolysis, and mitochondrial deficit jointly regulate the development of septic acute kidney injury (SAKI). This study aimed to explore the role of circular RNA HIPK3 (circHIPK3) in mitochondrial function in SAKI. The SAKI mouse model was established by Candida albicans infection, followed by Western blot assay, measurements of serum lactate, and adenosine triphosphate (ATP), 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimi-dazolylcarbocyanine iodide (JC-1) staining and flow cytometry.
View Article and Find Full Text PDFSyringin exerts anti-inflammatory and antioxidant effects by regulating SIRT1 signaling in rat and cell models of acute myocardial infarction.
Immun Inflamm Dis
February 2023
Department of Cardiology I, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Introduction: This study aimed to investigate the role of syringin in improving heart function during myocardial ischemia/reperfusion (I/R) and to determine whether the sirtuin 1/peroxisome proliferator-activated receptor gamma coactivator 1 alpha (SIRT1/PGC-1α) pathway contributes to this cardioprotective effect in vivo and in vitro.
Methods: H9c2 cells were incubated with H O for 12 h. The effect of syringin was assessed by measuring cell viability; the apoptotic rate; Keap1/NRF2/HO-1 activation; and the levels of proinflammatory cytokines, oxidative products, and antioxidative enzymes.
Mechanism of circHIPK3-miRNA-124-3p/miRNA-148b-3p-Mediated Inflammatory Responses and Cell Senescence in Candida albicans-Induced Septic Acute Kidney Injury.
Gerontology
February 2024
Department of Critical Care Medicine, The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University, Zhuhai, China.
Introduction: Sepsis is a life-threatening inflammatory state that can result in septic acute kidney injury (SAKI). Circular RNAs (circRNAs) are implicated in various inflammatory diseases including SAKI. This study investigated the effect of circHIPK3 on inflammatory responses and cell senescence in Candida albicans-induced SAKI.
View Article and Find Full Text PDFUtilizing single-cell RNA sequencing for analyzing the characteristics of PBMC in patients with Kawasaki disease.
BMC Pediatr
June 2021
The Department of Pediatric Cardiology, Shenzhen Children's Hospital of China Medical University, Shenzhen, 518038, China.
Background: Kawasaki disease (KD) is the main cause of acquired heart disease in children and can lead to coronary artery lesions. This present study was designed to analyze the characteristics of KD peripheral blood mononuclear cells (PBMC) through single-cell RNA sequencing (scRNA-seq) and to explore the potential molecular mechanism of KD.
Methods: PBMC was collected from one healthy child and one KD patient, and was used to single-cell RNA sequencing for cell clusters identification and differently expressed gene (DEG) determination.