Effects of a in the Hippocampus on Behavior, the Serotonin System, and BDNF.

The serotonin 5-HT receptor is one of the most abundant and widely distributed brain serotonin (5-HT) receptors that play a major role in the modulation of emotions and behavior. The 5-HT receptor gene () is under the control of transcription factor Freud-1 (also known as ). Here, using adeno-associated virus (AAV) constructs in vivo, we investigated effects of a in the hippocampus of C57BL/6J mice on behavior, the brain 5-HT system, and brain-derived neurotrophic factor (BDNF).