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Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model.
Am J Pathol
February 2022
The Eye Research Institute at Renhe Hospital of China Three Gorges University, Yichang City, Hubei Province, China. Electronic address:
Dry eye disease (DED) features the inflammatory response of the ocular surface. Pro-inflammatory T helper 17 (Th17) cells are important for the pathogenesis of DED. In the present study a mouse DED model was used to discover two Th17 subsets in draining lymph nodes and conjunctivae based on the expression of IL-17 receptor E (IL-17RE) and CCR10: IL-17RECCR10 Th17 and IL-17RECCR10 Th17.
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