108 results match your criteria: "The Ear Institute[Affiliation]"

Acute vertigo or dizziness is a frequent presentation to the emergency department (ED), making up between 2.1% and 4.4% of all consultations.

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Association between adult-onset hearing loss and dementia biomarkers: A systematic review.

Ageing Res Rev

December 2024

Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK; North London NHS Foundation Trust, London, 4 St Pancras Way, London NW1 0PE, UK. Electronic address:

Background And Objective: People with adult-onset hearing loss (AoHL) are at increased dementia risk. In this study, we explore potential aetiological mechanisms by synthesising the evidence on the association between AoHL and neuropathological, cerebrospinal fluid (CSF), blood and imaging biomarkers of dementia.

Methods: We systematically searched electronic databases from inception to 30 April 2024 for cross-sectional and longitudinal studies, including quantitative data on the association between AoHL and dementia biomarkers.

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Article Synopsis
  • Mosquito-borne viruses pose a major health threat globally, highlighting the need for effective personal protection against insect bites.
  • A new repellent compound, delta-undecalactone, showed exceptional efficacy, offering nearly 100% initial protection and over 50% bite prevention for over 7 hours when applied to skin and clothing.
  • Mathematical modeling suggests widespread use of this repellent could significantly reduce Zika virus infections during outbreaks, demonstrating its potential as a cost-effective strategy to combat arboviral diseases like dengue and chikungunya.
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Background: Stroke is the second leading cause of disability worldwide. Stroke results in focal neurological deficit and often leads to auditory problems due to its impact on the auditory pathway. Altered connections in the auditory pathway, caused by stroke, can result in hearing difficulties ranging from impaired sound detection to altered auditory perception.

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  • This study examines the relationship between mitochondrial diseases and hearing impairments, focusing on how specific genetic mutations affect auditory functions.
  • An observational study was conducted with 72 adults, utilizing various tests to assess both cochlear and central auditory capabilities, revealing significant hearing deficits linked to the m.3243A>G/T genetic variants.
  • The findings highlight the complexity of hearing impairment in mitochondrial diseases, suggesting that tailored auditory evaluations and management approaches may improve outcomes based on individual genetic profiles.
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  • Hearing impairment can be masked by neurological disorders like Temporal Lobe Epilepsy (TLE), affecting communication and mental health.
  • A systematic review evaluated tools for assessing auditory processing deficits in TLE patients, revealing significant differences from normal controls in both behavioral and electrophysiological tests.
  • The findings highlight the necessity of assessing hearing efficiency first, as incomplete peripheral hearing evaluations can lead to misinterpretation of auditory processing capabilities.
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  • The study investigated both peripheral (basic hearing ability) and central (speech processing ability) hearing in different dementia patients compared to healthy individuals.
  • Findings revealed that while central hearing (measured through dichotic listening) was significantly impaired in dementia patients, peripheral hearing (measured with pure-tone audiometry) showed no notable difference from healthy controls.
  • The results suggest a critical link between central hearing abilities and cognitive functioning in dementia, emphasizing the need to assess both types of hearing to better understand and address the auditory challenges faced by these patients.
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Motion sickness whilst reading as a passenger in the car is highly predictive of vestibular migraine.

Front Neurol

August 2024

Department of Clinical and Movement Neurosciences, Institute of Neurology, University College London, London, United Kingdom.

Background: Vestibular Migraine (VM) is a prevalent vestibular disorder, affecting up to 2.7% of the general population. Despite the establishment of diagnostic criteria by the Bárány Society and its inclusion in the International Classification of Headache Disorders, the clinical diagnosis of VM remains challenging due to its complex pathophysiology and symptom overlap with other dizziness disorders.

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  • Minimally invasive endoscopic procedures are safe and effective alternatives to surgery for treating a condition called Zenker's diverticulum (ZD), but there isn’t one best method agreed upon.
  • Researchers studied three different endoscopic techniques over ten years and found that flexible diverticulotomy (FD) and Zenker's peroral endoscopic myotomy (Z-POEM) had very high success rates.
  • Overall, these endoscopic methods work well and should be tried before considering surgery, which has more complications and can be less successful.
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Background: For adults with auditory processing disorder (APD), listening and communicating can be difficult, potentially leading to social isolation, depression, employment difficulties and certainly reducing the quality of life. Despite existing practice guidelines suggesting treatments, the efficacy of these interventions remains uncertain due to a lack of comprehensive reviews. This systematic review and meta-analysis aim to establish current evidence on the effectiveness of interventions for APD in adults, addressing the urgent need for clarity in the field.

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Adult-onset hearing loss and incident cognitive impairment and dementia - A systematic review and meta-analysis of cohort studies.

Ageing Res Rev

July 2024

Division of Psychiatry, University College London, 6th Floor, Maple House, 149 Tottenham Court Road, London W1T 7NF, England. Electronic address:

Background: We comprehensively summarized the cohort evidence to date on adult-onset hearing loss as risk factor for incident cognitive impairment and dementia, and examined the evidence for dose-response, risk for various dementia subtypes, and other moderators. Previous meta-analyses were less comprehensive.

Methods: We included cohort studies with participants without dementia and with hearing assessments at baseline, minimum 2 years follow-up and incident cognitive outcomes.

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Objective: To investigate (1) the current level of awareness and knowledge on Auditory Processing Disorder (APD) among Audiologists and other hearing healthcare professionals; (2) current practices in screening, diagnosis, and management of APD in children and adults across the UK; (3) professional's acceptance of APD assessment and diagnosis.

Design: An online survey was disseminated through the British Academy of Audiology and ENT UK.

Study Sample: A total of 191 hearing healthcare professionals responded to the survey.

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Article Synopsis
  • The study aimed to improve surgical planning for vestibular schwannoma surgery by developing a method to accurately outline the facial-vestibulocochlear nerve complex using a refined diffusion-weighted imaging (rs-DWI) approach.
  • In a trial with five healthy volunteers and five patients, researchers generated color tissue maps and analyzed the accuracy of nerve segmentation through various measurements that compared preoperative imaging and intraoperative results.
  • Results indicated that the method effectively visualized the nerve complex, showing high accuracy in identifying the facial nerve, which is crucial for reducing complications during surgery.
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Reflexive and volitional saccadic eye movements and their changes in age and progressive supranuclear palsy.

J Neurol Sci

December 2022

Centre for Vestibular and Behavioural Neurosciences, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK; The Ear Institute, University College London, London, UK. Electronic address:

Background And Objectives: Saccades, rapid movements of the eyes towards a visual or remembered target, are useful in understanding the healthy brain and the pathology of neurological conditions such as progressive supranuclear palsy (PSP). We set out to investigate the parameters of horizontal reflexive and volitional saccades, both visually guided and memory-guided, over a 1 min epoch in healthy individuals and PSP patients.

Methods: An experimental paradigm tested reflexive, volitional visually guided, and volitional memory-guided saccades in young healthy controls (n = 14; 20-31 years), PSP patients (n = 11; 46-75 years) and older age-matched healthy controls (n = 6; 56-71 years).

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Vestibular Migraine (VM) is the most common cause of non-positional episodic vestibular symptoms. Patients with VM commonly report increased motion sensitivity, suggesting that vestibular responses to head movement may identify changes specific to VM patients. Here we explore whether the vestibulo-ocular reflex (VOR) gain alters in response to a clinical "headshake" maneuver in patients with VM.

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Video head impulse testing: Pitfalls in neurological patients.

J Neurol Sci

November 2022

Centre for Vestibular and Behavioural Neurosciences, Department of Clinical and Movement Neurosciences, Institute of Neurology, University College London, Queen Square, London, UK; The Ear Institute, University College London, London, UK; Department of Neuro-otology, Royal national ENT and Eastman Dental Hospitals, University College London Hospitals, London, UK. Electronic address:

The video head impulse test (vHIT) assesses the vestibulo-ocular reflex (VOR) during a rapid high-velocity low amplitude (10°-20°) head rotation. Patients with peripheral vestibulopathy have a reduced VOR gain with corrective catch-up saccades during the head turn. There are several pitfalls, mainly technical, which may interfere with interpretation of vHIT data.

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The cochlea decomposes sounds into separate frequency channels, from which the auditory brain must reconstruct the auditory scene. To do this the auditory system must make decisions about which frequency information should be grouped together, and which should remain distinct. Two key cues for grouping are temporal coherence, resulting from coherent changes in power across frequency, and temporal predictability, resulting from regular or predictable changes over time.

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Health-Related Quality of Life in Adults With Classical Infratentorial Superficial Siderosis: A Cross-sectional Study.

Neurology

November 2022

From the Ear Institute (N.K., D.-E.B.), Stroke Research Centre (D.W.), Department of Brain Repair and Rehabilitation, Queen Square Institute of Neurology (A.A.M.), and Department of Statistical Science (M.P.), University College London; and National Institute for Health and Care Research (N.K., D.-E.B.), University College London Hospitals Biomedical Research Centre (Deafness and Hearing Problems Theme), London; Southampton School of Medicine (A.A.M.), University of Southampton, UK.

Background And Objectives: Infratentorial superficial siderosis (iSS) is a rare but disabling neurologic condition characterized by progressive hearing loss and balance and mobility problems. The functional decline in these neurologic domains with iSS progression is likely to adversely affect health-related quality of life (HRQoL). We studied the HRQoL of adults with iSS using 2 common generic HRQoL measures (Health Utilities Index Mark III [HUI3] and EuroQoL EQ5D [5 Level]) to determine the most affected domains and evaluate the association between HRQoL scores and disease duration.

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Introduction: Vestibular migraine (VM) is a common condition; individuals experience dizziness with migraine symptoms. Vestibular rehabilitation therapy (VRT) has been reported as an effective treatment for VM, however, evidence is limited. VM and traumatic brain injury (TBI) can co-occur, and some suggest that TBI can induce VM.

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Neuro-oncology surgery would benefit from detailed intraoperative tissue characterization provided by noncontact, contrast-agent-free, noninvasive optical imaging methods. In-depth knowledge of target tissue optical properties across a wide-wavelength spectrum could inform the design of optical imaging and computational methods to enable robust tissue analysis during surgery. We adapted a dual-beam integrating sphere to analyse small tissue samples and investigated ex vivo optical properties of five types of human brain tumour (meningioma, pituitary adenoma, schwannoma, low- and high-grade glioma) and nine different types of healthy brain tissue across a wavelength spectrum of 400 to 1800 nm.

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Objective: A high prevalence of hearing loss in older adults contrasts with a small proportion of people who seek help. Emerging developments in hearing healthcare (HHC) could reduce costs but may not increase access. This study evaluated older adults' perceptions of current and future HHC services in Australia, England, US and Canada to explore potential levers and system improvements.

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