2 results match your criteria: "The Drum Tower Clinical Medical School of Nanjing Medical University[Affiliation]"
Vγ6γδT Cells Participate in Lupus Nephritis in MRL/Lpr Mice.
Int J Rheum Dis
January 2025
Department of Rheumatology and Immunology, The Drum Tower Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: γδT cells have been implicated in the pathogenesis of autoimmune diseases. The study aims to investigate the abundance of γδT cells in MRL/lpr mice.
Methods: MRL/lpr mice were used as lupus models, while C3H/HeJ mice served as normal controls.
Metabolic alterations in vitamin D deficient systemic lupus erythematosus patients.
Sci Rep
August 2024
Department of Rheumatology and Immunology, The Drum Tower Clinical Medical School of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.
Article Synopsis
- - Vitamin D deficiency is common in systemic lupus erythematosus (SLE) patients and correlates with increased disease activity and proteinuria; a study analyzed serum samples to explore metabolic changes related to this deficiency.
- - Using untargeted metabolomics, researchers identified 52 metabolites significantly altered in vitamin D deficient SLE patients, with lipids making up two-thirds of these changes, pointing to disrupted lipid metabolism.
- - Analysis revealed key metabolic pathways impacted, including fat digestion and absorption, and identified potential biomarkers like (S)-Oleuropeic acid and 2-Hydroxylinolenic acid that could aid in diagnosing SLE, demonstrating the connection between vitamin D deficiency and its metabolic effects on the disease.